Ying Liu,Xuhui Feng,Han Wu et al.
Ying Liu et al.
IRBIT1 and IRBIT2 (collectively, the IRBITs) are signaling molecules with great universality in their expression (ubiquitous distribution in all major tissues in animals) and considerable versatility in their biological functions. Structura...
Role of oxidative/nitrosative stress in dysfunction of rat's intracerebral parenchymal arterioles in low sodium environment in the presence of vasopressin [0.03%]
低钠和血管加压素环境下氧化/硝基化应激对大鼠脑内皮质细动脉功能障碍的影响
Marta Aleksandrowicz
Marta Aleksandrowicz
Hyponatremia is the most common electrolyte disturbance in hospitalized patients. Symptoms of hyponatremia include attention deficits and cognitive impairments. The cause of such abnormalities may be disturbances in the regulation of microc...
SECS, drugs, and Rac1&Rho: regulation of EnNaC in vascular endothelial cells [0.03%]
SECS、药物和Rac1/Rho：血管内皮细胞中EnaC的调节
Benedikt Fels,Felix Fischer,Lisbeth Herrnboeck et al.
Benedikt Fels et al.
The endothelial ENaC (EnNaC) is mainly responsible for maintaining the mechanical properties of the endothelial cell surface, the sensitivity to the shear forces of the streaming blood and thus for vascular function. The correlation between...
The relevance of RNA-DNA interactions as regulators of physiological functions [0.03%]
RNA-DNA相互作用在生理功能调控中的意义
Julia Stötzel,Timothy Warwick,Praveenya Tirunagari et al.
Julia Stötzel et al.
RNA-DNA interactions are fundamental to cellular physiology, playing critical roles in genome integrity, gene expression, and stress responses. This review highlights the diverse structures of RNA-DNA hybrids, including R-loops, RNA-DNA tri...
Targeting NLRP3 inflammasome attenuates cardiac pyroptosis and fibrosis in estrogen-deficient diabetic rats [0.03%]
靶向NLRP3炎症小体可减轻雌激素缺乏糖尿病大鼠心脏pyroptosis及纤维化
Sukanya Phungphong,Phichaya Suthivanich,Worakan Boonhoh et al.
Sukanya Phungphong et al.
Cardiac diastolic dysfunction is a hallmark of diabetic cardiomyopathy (DCM), particularly in postmenopausal women where estrogen deficiency exacerbates cardiac remodeling. This study investigated the roles of NLRP3 inflammasome activation ...
Ethanol-induced dysfunction of the mesenteric perivascular adipose tissue is driven by mineralocorticoid receptors [0.03%]
酒精通过矿化固醇受体诱导肠系膜血管周脂肪组织功能障碍
Ivis V O Martins,Thales M H Dourado,Gustavo F Pimenta et al.
Ivis V O Martins et al.
The renin-angiotensin-aldosterone system (RAAS) is critical in ethanol-induced vascular dysfunction. Mineralocorticoid receptors (MR) trigger ethanol-induced vascular hypercontractility through pro-oxidative and pro-inflammatory effects. Ho...
Thermosensitivity of TREK K2P channels is controlled by a PKA switch and depends on the microtubular network [0.03%]
PKA介导的微管结合调控TREK钾通道热敏感性
Sönke Cordeiro,Marianne Musinszki
Sönke Cordeiro
Temperature sensing is an essential component of animal perception and enables individuals to avoid painful or lethal temperatures. Many temperature sensors in central and peripheral neurons are ion channels. Here, we focus on the thermosen...
Characterization of ROMK cellular heterogeneity along the mouse kidney thick ascending limb [0.03%]
小鼠肾脏髓袢升支粗段ROMK的细胞异质性分析
Christian Keller,Rui Ramos Santos,Wouter H van Megen et al.
Christian Keller et al.
The renal thick ascending limb (TAL) plays a key role in water and ion homeostasis. Apical potassium secretion via the renal outer medullary potassium channel (ROMK) is essential for transepithelial sodium reabsorption via the furosemide-se...
Probiotic Bactolac alleviates depression-like behaviors by modulating BDNF, NLRP3 and MC4R levels, reducing neuroinflammation and promoting neural repair in rat model [0.03%]
益生菌Bactolac通过调节BDNF，NLRP3和MC4R水平，减少神经炎症并促进神经修复来缓解抑郁样行为（大鼠模型）
Musab Işık,Fadime Köse,Özcan Budak et al.
Musab Işık et al.
Depression, a prevalent psychiatric disorder, exerts severe and debilitating impacts on an individual's mental and physical well-being, and it is considered a chronic mental illness. Chronic stress plays an important role in the pathophysio...
Edward R Smith,Stephen G Holt
Edward R Smith
Vertebrate extracellular fluids lie below the threshold for spontaneous calcium phosphate (Ca-Pi) precipitation; yet, they remain supersaturated enough to foster crystal growth if unchecked. Calciprotein particles (CPP) and their smaller pr...