ER stress inhibitor 4PBA attenuates hindlimb unloading-induced cardiac mitochondrial and metabolic dysfunction [0.03%]
自噬诱导剂4PBA缓解失载所致心脏线粒体和代谢功能障碍
Firdos Ahmad,Anupriya Sinha,Asima Karim et al.
Firdos Ahmad et al.
Macrophages in metaflammation - fueling chronic inflammation in metabolic disease [0.03%]
代谢性疾病中慢性炎症的驱动因素——元炎症巨噬细胞
Ronja Kardinal,Dagmar Wachten
Ronja Kardinal
Obesity is a leading global health issue, closely associated with a chronic low-grade inflammation termed metaflammation. Metaflammation is driven by immune cell reprogramming, particularly of macrophages. In white adipose tissue (WAT), obe...
An in-depth look at shallow-water walking: the mechanical determinants of the energy metabolic cost of shallow water walking in humans [0.03%]
浅谈浅水行走：人体在浅水环境中行进时能量代谢成本的力学决定因素分析
André Ivaniski-Mello,Alberto Enrico Minetti,Flávia Gomes Martinez et al.
André Ivaniski-Mello et al.
Human locomotion in water involves unique forces (buoyancy, drag) influencing metabolic cost. However, a validated model integrating these forces to predict the cost of transport (COT) during shallow water walking (SWW) is lacking, and ener...
Marvin J A Meyer,George Oprita,Tabea C Fricke et al.
Marvin J A Meyer et al.
The ion channel TRPV2 has multiple roles in immunology, cancer, cardiovascular function and pain signaling. However, only few endogenous modulators of TRPV2 have been described. The phospholipase A2 (PLA2)-derived lipid lysophosphatidylchol...
Hippocampal synaptic plasticity impairment and melatonin synthesis reduction in cognitive decline of a rodent model of Alzheimer's disease-like pathology [0.03%]
阿尔茨海默病样啮齿动物模型中认知下降与海马长时程增强损伤及松果体褪黑素合成降低的关系
Leila Karimi-Zandi,Samaneh Aminyavari,Maryam Zahmatkesh
Leila Karimi-Zandi
Melatonin, the pineal gland hormone, is produced in several extra-pineal tissues. The arylalkylamine N-acetyltransferase (AANAT) enzyme activity determines the overall rate of tissue melatonin synthesis. A decline in AANAT enzyme activity d...
From chaos to control: Nobel insights in regulatory T cells and immune tolerance [0.03%]
从混沌到控制——诺贝尔奖得主论调节性T细胞及免疫耐受诱导机制
Anna Estrada Brull,Nicole Joller
Anna Estrada Brull
Differential effect of pulsatile pressure on the myogenic responses of small arteries [0.03%]
脉动压力对小动脉肌性反应的差异化效应
André Budrowitz,Mitko Mladenov,Hristo Gagov et al.
André Budrowitz et al.
The myogenic response is an important regulatory mechanism under physiological as well as pathophysiological conditions. However, little is known about the myogenic response under pulsatile pressure conditions. Therefore, based on the known...
Resistance exercise training attenuates skeletal muscle atrophy in experimental pulmonary arterial hypertension [0.03%]
阻力锻炼训练可减轻实验性肺动脉高压患者的肌肉萎缩
Sebastião Felipe Ferreira Costa,Luciano Bernardes Leite,Leôncio Lopes Soares et al.
Sebastião Felipe Ferreira Costa et al.
To evaluate the effects of a resistance training (RT) program applied during the development of MCT-induced pulmonary arterial hypertension (PAH) on skeletal muscle atrophy in rats. Twenty-one male Wistar rats were randomly distributed into...
Metabolic syndrome reduces but does not eliminate the cardioprotective effect of adaptation to hypoxia: the link with changes in the opioid system [0.03%]
代谢综合征降低了但并未消除缺氧预适应的心脏保护效应：与阿片样物质系统的变化有关联
Natalia V Naryzhnaya,Ivan A Derkachev,Boris K Kurbatov et al.
Natalia V Naryzhnaya et al.
Chronic continuous hypoxia (CCH) demonstrates a pronounced protective effect in cardiac ischemia-reperfusion (IR). Opioids and opioid receptors play a significant role in this process. It has been previously shown that metabolic syndrome (M...