Parathyroid hormone enhances appetite and fails to reduce adiposity in ob/ob mice [0.03%]
甲状旁腺激素能增强肥胖小鼠的食欲，并不能减轻肥胖小鼠的脂肪率
Abul Fajol,Hirotaka Komaba,Chigusa Ishioka et al.
Abul Fajol et al.
Obesity is a major driver of type 2 diabetes, underscoring the urgent need for therapies that target both energy expenditure and glucose homeostasis. Parathyroid hormone (PTH) has been implicated in promoting adipose tissue browning and the...
Oestrogen receptors regulate vascular β₁- and β₃-adrenoceptor expression and shape sex-specific adrenergic control of vascular tone [0.03%]
雌激素受体调节血管β₁-和β₃-肾上腺素受体表达并塑造性别特异性的肾上腺素控制血管张力的机制
Kristin Riedel,Andreas Deussen,Birgit Zatschler et al.
Kristin Riedel et al.
Sex differences in vascular adrenergic responsiveness contribute to differential regulation of vascular tone. Female vessels exhibit enhanced β-adrenergic relaxation compared with males, but the role of oestrogen receptors in maintaining t...
Chronic atorvastatin treatment weakens procontractile influence of NADPH oxidase derived ROS in systemic murine arteries [0.03%]
他汀类药物慢性处理削弱系统性动脉中NADPH氧化酶产生的ROS的促收缩影响
Anastasia A Shvetsova,Guzalia F Zakirjanova,Kseniia P Ostapchuk et al.
Anastasia A Shvetsova et al.
The beneficial effects of statins for cardiovascular system were widely described in various pathologies. However, much less is known about the effects of statins in healthy organism, especially in systemic resistance arteries. We aimed to ...
KCa3.1 mediates radioresistance of silver nanoparticles in human glioblastoma cells [0.03%]
银纳米颗粒通过KCa3.1介导的人胶质母细胞瘤细胞放射抵抗性研究
Francesco Ragonese,Andrea Biagini,Luana Sallicandro et al.
Francesco Ragonese et al.
Silver nanoparticles (AgNPs) have emerged as a promising therapeutic tool for managing glioblastoma (GB), particularly in radiosensitisation. However, their mechanisms of action are not yet fully understood. Since ion channel activity is im...
Spexin disrupts migrating myoelectric complex in the rat small intestine: The role of galanin-2 and muscarinic receptors [0.03%]
一种新型肽类化合物spexin干扰大鼠小肠迁移肌电复合波：胃泌素释放肽受体和胆囊收缩素受体的作用
Özge Darakcı Saltık,Hakan Balcı,Rümeysa Abdullahoğlu et al.
Özge Darakcı Saltık et al.
Spexin (SPX) is an endogenous peptide expressed throughout the gastrointestinal tract. Although its impact on postprandial intestinal motility has been examined, its effect during fasting remains unclear. This study aimed to investigate the...
Exercise-induced microRNAs: molecular pathways and adaptive remodeling of skeletal muscle [0.03%]
运动引起的microRNA：分子途径与骨骼肌的适应性重塑
Kübra Özdemir,Yeliz Demir
Kübra Özdemir
Exercise is an effective physiological stimulus that promotes vast structural and functional changes in skeletal muscular tissue. Although transcriptional pathways that control exercise-based plasticity have been studied in depth, recent fi...
The role of IP3R and TRPC3 channels in vasoconstriction and hypertension [0.03%]
IP3受体和TRPC3通道在血管收缩和高血压中的作用
Raiana Dos Anjos Moraes,Quiara Lovatti Alves,Liliane Barreto da Silva et al.
Raiana Dos Anjos Moraes et al.
Hypertension is a major global health concern and a leading risk factor for cardiovascular diseases, including stroke, myocardial infarction, and heart failure. A hallmark of hypertension is elevated total peripheral vascular resistance, of...
Angiotensin converting enzyme-2 activation mitigates glucocorticoids-induced osteoporosis in rats by modulating oxidative stress, inflammation and the RANKL/OPG pathway [0.03%]
血管紧张素转换酶-2通过调节氧化应激、炎症和RANKL / OPG通路来缓解糖皮质激素引起的绝经后骨丢失小鼠的骨质疏松症
Heba Fathy El-Domiaty,Mohamed Abdallah,Nesrin Abd Allah Salman et al.
Heba Fathy El-Domiaty et al.
Role of autonomic receptors in ethyl ferulate-induced cardiovascular effects in normotensive and hypertensive female rats [0.03%]
大鼠乙基ferulate诱导的自主受体在心血管效应中的作用normotensive和高血压女性
Francisca Valdirene de S Nunes,Samuel S P Araujo,Juliana A da Silva et al.
Francisca Valdirene de S Nunes et al.
Aims: Ethyl ferulate (EF) may offer novel benefits in hypertension. We investigated the contribution of autonomic receptors to EF-induced effects in female Wistar and SHR. ...
Guinea pig δβγ-ENaC is locked in an open state and uncoupled from regulation by proteases [0.03%]
Guinea pig δβγ-ENaC 保持在开放状态且不受蛋白酶调节
Rene Yufenyuy Lawong,Etang Collins Etang,Fabian May et al.
Rene Yufenyuy Lawong et al.
The epithelial sodium channel (ENaC) plays a key role in salt and water homeostasis in tetrapod vertebrates. There are four ENaC subunits (α, β, γ and δ) which form heterotrimeric αβγ- or δβγ-ENaC assemblies. ENaC activity is tigh...