Hippocampal synaptic plasticity impairment and melatonin synthesis reduction in cognitive decline of a rodent model of Alzheimer's disease-like pathology [0.03%]
阿尔茨海默病样啮齿动物模型中认知下降与海马长时程增强损伤及松果体褪黑素合成降低的关系
Leila Karimi-Zandi,Samaneh Aminyavari,Maryam Zahmatkesh
Leila Karimi-Zandi
Melatonin, the pineal gland hormone, is produced in several extra-pineal tissues. The arylalkylamine N-acetyltransferase (AANAT) enzyme activity determines the overall rate of tissue melatonin synthesis. A decline in AANAT enzyme activity d...
From chaos to control: Nobel insights in regulatory T cells and immune tolerance [0.03%]
从混沌到控制——诺贝尔奖得主论调节性T细胞及免疫耐受诱导机制
Anna Estrada Brull,Nicole Joller
Anna Estrada Brull
Differential effect of pulsatile pressure on the myogenic responses of small arteries [0.03%]
脉动压力对小动脉肌性反应的差异化效应
André Budrowitz,Mitko Mladenov,Hristo Gagov et al.
André Budrowitz et al.
The myogenic response is an important regulatory mechanism under physiological as well as pathophysiological conditions. However, little is known about the myogenic response under pulsatile pressure conditions. Therefore, based on the known...
Resistance exercise training attenuates skeletal muscle atrophy in experimental pulmonary arterial hypertension [0.03%]
阻力锻炼训练可减轻实验性肺动脉高压患者的肌肉萎缩
Sebastião Felipe Ferreira Costa,Luciano Bernardes Leite,Leôncio Lopes Soares et al.
Sebastião Felipe Ferreira Costa et al.
To evaluate the effects of a resistance training (RT) program applied during the development of MCT-induced pulmonary arterial hypertension (PAH) on skeletal muscle atrophy in rats. Twenty-one male Wistar rats were randomly distributed into...
Metabolic syndrome reduces but does not eliminate the cardioprotective effect of adaptation to hypoxia: the link with changes in the opioid system [0.03%]
代谢综合征降低了但并未消除缺氧预适应的心脏保护效应：与阿片样物质系统的变化有关联
Natalia V Naryzhnaya,Ivan A Derkachev,Boris K Kurbatov et al.
Natalia V Naryzhnaya et al.
Chronic continuous hypoxia (CCH) demonstrates a pronounced protective effect in cardiac ischemia-reperfusion (IR). Opioids and opioid receptors play a significant role in this process. It has been previously shown that metabolic syndrome (M...
Protective effects of low-dose lithium treatment on rat postural muscle under conditions of disuse [0.03%]
低剂量锂治疗对废用条件下大鼠站立肌的保护作用
Timur M Mirzoev,Sergey A Tyganov,Olga V Turtikova et al.
Timur M Mirzoev et al.
Revisiting the relationship between pulse transit time and arterial stiffness [0.03%]
重新审视脉搏传导时间与动脉僵硬度之间的关系
Masayoshi Yoshida,Hilmi R Dajani,Miodrag Bolic et al.
Masayoshi Yoshida et al.
Unlike secondary prevention, primary prevention of the major cardiovascular events has not yet been successful. One of the reasons is that current methodology has not succeeded in selecting high risk patients who are suitable candidates for...
Sex differences in phenotypic modulation of microglia by early-life physical stress in a rat model of chronic primary low back pain [0.03%]
大鼠慢性原发性下背痛模型中早期生活应激源引起的微胶质细胞表型改变的性别差异研究
Deepika Singhal,Jonathan R Husk,Wolfgang Greffrath et al.
Deepika Singhal et al.
Chronic primary low back pain (cpLBP) is a leading contributor to years lived with disability. Early-life stress is a major risk factor predisposing to cpLBP later in life upon minor injuries. We investigated sex differences in the involvem...
Circadian adaptations to regular treadmill exercise alter temporal changes in dopamine and serotonin activity in brain areas [0.03%]
昼夜适应规律跑步机运动改变大脑多巴胺和血清素的动态变化
Frederico Sander Mansur Machado,Nayara Abreu Coelho Horta,Quezia Teixeira Rodrigues et al.
Frederico Sander Mansur Machado et al.
The beneficial effects of regular exercise may be mediated through its regulatory influence on circadian rhythm. Here, we investigated how regular exercise training affects spontaneous locomotor activity (SLA) and body temperature (T-body) ...