Unlocking the potential: unveiling tyrphostins with Michael-reactive cyanoacrylate motif as promising inhibitors of human 5-lipoxygenase [0.03%]
潜力解锁：揭示具有迈克尔反应型氰基丙烯酸酯配体的 tyrphostin 类化合物作为人类 5-LO 抑制剂的研究
Maximilian Molitor,Amelie Menge,Sebastian Mandel et al.
Maximilian Molitor et al.
Human 5-lipoxygenase (5-LO) is the key enzyme in the biosynthesis of leukotrienes, mediators of the innate immune system that also play an important role in inflammatory diseases and cancer. In this study, we present compounds, containing a...
K2P2.1 channels modulate the pH- and mechanosensitivity of pancreatic stellate cells [0.03%]
K2P2.1通道调节胰星状细胞的pH和机械敏感性
Micol Rugi,Verena Hofschröer,Zoltán Pethő et al.
Micol Rugi et al.
Pancreatic stellate cells (PSCs) are central in the development of acute pancreatitis and tumor fibrosis in pancreatic ductal adenocarcinoma (PDAC). Fibrosis and a unique pH landscape represent characteristic properties of the PDAC microenv...
Optimization of an autaptic culture system for studying cholinergic synapses in sympathetic ganglia [0.03%]
一种用于研究交感神经节胆碱能突触的自突触培养系统的优化方法研究
Seong Jun Kang,Huu Son Nguyen,Choong-Ku Lee et al.
Seong Jun Kang et al.
An autaptic synapse (or 'autapse') is a functional connection between a neuron and itself, commonly used in studying the molecular mechanisms underlying synaptic transmission and plasticity in central neurons. Most previous studies on auton...
Atypical sphingosine-1-phosphate metabolites-biological implications of alkyl chain length [0.03%]
非常规的丝氨醇-1-磷酸代谢物-烷基链长度的生物学意义
Melanie Glueck,Alexandra Lucaciu,Julien Subburayalu et al.
Melanie Glueck et al.
Sphingosine-1-phosphate (S1P) is a bioactive lipid signaling molecule with pleiotropic implications by both auto- and paracrine signaling. Signaling occurs by engaging five G protein-coupled receptors (S1P1-5) or intracellular pathways. Whi...
Anthony H Futerman
Anthony H Futerman
Research on sphingolipids has proliferated exponentially over the past couple of decades, as exemplified in the findings reported at the International Leopoldina Symposium on Lipid Signaling held in Frankfurt in late 2023. Most researchers ...
Characterization of intestine-specific TRPM6 knockout C57BL/6 J mice: effects of short-term omeprazole treatment [0.03%]
特异敲除小肠TRPM6的C57BL/6J小鼠的表征及短期奥美拉唑处理的影响
Anastasia Adella,Lisanne M M Gommers,Caro Bos et al.
Anastasia Adella et al.
The transient receptor potential melastatin type 6 (TRPM6) is a divalent cation channel pivotal for gatekeeping Mg2+ balance. Disturbance in Mg2+ balance has been associated with the chronic use of proton pump inhibitors (PPIs) such as omep...
Jonathan L Gillan,Lara Jaeschke,Wolfgang M Kuebler et al.
Jonathan L Gillan et al.
It is often the case that serious, end-stage manifestations of disease result from secondary complications in organs distinct from the initial site of injury or infection. This is particularly true of diseases of the heart-lung axis, given ...
Salt-sensitive hypertension in GR mutant rats is associated with altered plasma polyunsaturated fatty acid levels and aortic vascular reactivity [0.03%]
GR突变大鼠盐敏感性高血压与血浆多不饱和脂肪酸水平变化和主动脉血管反应性的关联研究
S Verouti,G Aeschlimann,Q Wang et al.
S Verouti et al.
In humans, glucocorticoid resistance is attributed to mutations in the glucocorticoid receptor (GR). Most of these mutations result in decreased ligand binding, transactivation, and/or translocation, albeit with normal protein abundances. H...
Physiological simulation of atrial-ventricular mechanical interaction in male rats during the cardiac cycle [0.03%]
大鼠心脏周期中房室机械相互作用的生理模拟
Alexandr Balakin,Yuri Protsenko
Alexandr Balakin
Adequate assessment of the contribution of the different phases of atrial mechanical activity to the value of ejection volume and pressure developed by the ventricle is a complex and important experimental and clinical problem. A new method...
Immune-mediated impairment of tonic immobility defensive behavior in an experimental model of colonic inflammation [0.03%]
一种结肠炎实验模型中免疫介导的固有不动防御行为障碍
Leda Menescal-de-Oliveira,Mariulza Rocha Brentegani,Fernanda Pincelli Teixeira et al.
Leda Menescal-de-Oliveira et al.
Ulcerative colitis has been associated with psychological distress and an aberrant immune response. The immunomodulatory role of systemic cytokines produced during experimental intestinal inflammation in tonic immobility (TI) defensive beha...