TRPC3-mediated NFATc1 calcium signaling promotes triple negative breast cancer migration through regulating glypican-6 and focal adhesion [0.03%]
瞬时受体电位通道C3介导的NFATc1钙信号通过调节Glypican-6和粘着斑促进三阴性乳腺癌迁移
Yan Wang,Xiaosheng Zhuang,Yanxiang Qi et al.
Yan Wang et al.
Canonical transient receptor potential isoform 3 (TRPC3), a calcium-permeable non-selective cation channel, has been reported to be upregulated in breast cancers and a modulator of cell migration. Calcium-sensitive transcription factor NFAT...
Challenges and applications in generative AI for clinical tabular data in physiology [0.03%]
生理学临床表格数据的生成AI面临的挑战与应用
Chaithra Umesh,Manjunath Mahendra,Saptarshi Bej et al.
Chaithra Umesh et al.
Recent advancements in generative approaches in AI have opened up the prospect of synthetic tabular clinical data generation. From filling in missing values in real-world data, these approaches have now advanced to creating complex multi-ta...
Cellular mechanisms of synchronized rhythmic burst generation in the ventromedial hypothalamus [0.03%]
腹内侧下丘脑同步节律放电的细胞机制研究
Kamon Iigaya,Hiroshi Onimaru,Keiko Ikeda et al.
Kamon Iigaya et al.
The ventromedial hypothalamus (VMH) plays an important role in feeding behavior and control of the sympathetic nervous system (SNS). The VMH includes a group of neurons that exhibit strong synchronized rhythmic burst firing (so-called VMH o...
A role for plasma membrane Ca2+ ATPases in regulation of cellular Ca2+ homeostasis by sphingosine kinase-1 [0.03%]
鞘氨醇激酶-1通过调控细胞Ca2+稳态中的膜联Ca2+-ATP酶发挥功能
Luisa Michelle Volk,Jan-Erik Bruun,Sandra Trautmann et al.
Luisa Michelle Volk et al.
Sphingosine-1-phosphate (S1P) is a ubiquitous lipid mediator, acting via specific G-protein-coupled receptors (GPCR) and intracellularly. Previous work has shown that deletion of S1P lyase caused a chronic elevation of cytosolic [Ca2+]i and...
Characterization of human placental fetal vessels in gestational diabetes mellitus [0.03%]
妊娠糖尿病的人胎盘胎儿血管特征化研究
Philine S Carstens,Heike Brendel,M Leyre Villar-Ballesteros et al.
Philine S Carstens et al.
Gestational diabetes mellitus is one of the most common complications during pregnancy. Its prevalence is rapidly increasing worldwide. Gestational diabetes mellitus is leading to an elevated risk for the development of endothelial dysfunct...
The contribution of the sphingosine 1-phosphate signaling pathway to chronic kidney diseases: recent findings and new perspectives [0.03%]
鞘氨醇-1-磷酸信号通路在慢性肾脏疾病中作用的研究进展及新思考
Stephanie Schwalm,Roxana Manaila,Anke Oftring et al.
Stephanie Schwalm et al.
Chronic kidney disease (CKD) is a multifactorial condition with diverse etiologies, such as diabetes mellitus, hypertension, and genetic disorders, often culminating in end-stage renal disease (ESRD). A hallmark of CKD progression is kidney...
ACE2 and TMPRSS2 in human kidney tissue and urine extracellular vesicles with age, sex, and COVID-19 [0.03%]
年龄、性别与COVID-19对人类肾脏组织和尿液外泌体中ACE2和TMPRSS2的影响
Marie Lykke Bach,Sara Laftih,Jesper K Andresen et al.
Marie Lykke Bach et al.
SARS-CoV-2 virus infects cells by engaging with ACE2 requiring protease TMPRSS2. ACE2 is highly expressed in kidneys. Predictors for severe disease are high age and male sex. We hypothesized that ACE2 and TMPRSS2 proteins are more abundant ...
Pioneering new paths: the role of generative modelling in neurological disease research [0.03%]
开拓新路径：生成模型在神经疾病研究中的作用
Moritz Seiler,Kerstin Ritter
Moritz Seiler
Recently, deep generative modelling has become an increasingly powerful tool with seminal work in a myriad of disciplines. This powerful modelling approach is supposed to not only have the potential to solve current problems in the medical ...
Phosphatidic acid is involved in regulation of autophagy in neurons in vitro and in vivo [0.03%]
磷脂酸通过体内和体外研究被发现参与神经元自噬的调节
Maximilian Schiller,Gregory C Wilson,Simone Keitsch et al.
Maximilian Schiller et al.
Major depressive disorder (MDD) is a common and severe psychiatric disease, which does not only lead to variety of neuropsychiatric symptoms, but unfortunately in a relatively large proportion of cases also to suicide. The pathogenesis of M...
Physiological regulation of oral saliva ion composition and flow rate are not coupled in healthy humans-Partial revision of our current knowledge required [0.03%]
健康人体内生理调节口腔唾液离子组成和流速并非耦合的部分修订我们目前的知识要求
Gerald Schwerdt,Marie-Christin Schulz,Michael Kopf et al.
Gerald Schwerdt et al.
Appropriate composition of oral saliva is essential for a healthy milieu that protects mucosa and teeth. Only few studies, with small sample numbers, investigated physiological saliva ion composition in humans. We determined saliva ion comp...