Estrogen hindrance escalates inflammation and neurodegeneration in the hippocampal regions of collagen-induced arthritis female Sprague-Dawley rats [0.03%]
雌激素缺乏加重胶原诱导的Sprague-Dawley大鼠关节炎全脑炎症及海马神经退行性病变
Zuo Hao Lee,Wong Siew Tung,Kabileshvaran A/L Jana Santhiran et al.
Zuo Hao Lee et al.
This study aims to investigate the effect of estrogen hindrance, i.e., menopause in women for instance with rheumatoid arthritis on the brain hippocampal region by using collagen-induced arthritis (CIA) female rat model (RA). CIA was induce...
The lateral habenula regulates stress-related respiratory responses via the monoaminergic system [0.03%]
侧缰核通过单胺能系统调节应激相关的呼吸反应
Riko Mizukami,Masayuki Matsumoto,Tadachika Koganezawa
Riko Mizukami
Psychologic stress induces behavioral and autonomic responses such as acceleration of respiration. The lateral habenula (LHb) is noted to be involved in stress-induced behavioral responses. However, its involvement in stress-induced respira...
Fatiguing high-intensity intermittent exercise depresses maximal Na+-K+-ATPase activity in human skeletal muscle assessed using a novel NADH-coupled assay [0.03%]
一种新的NADH偶联实验评估了疲劳高强度间歇运动使人体骨骼肌最大Na+–K+–ATP酶活性降低
Jeppe F Vigh-Larsen,Sara M Frangos,Kristian Overgaard et al.
Jeppe F Vigh-Larsen et al.
The Na+-K+-ATPase is a critical regulator of ion homeostasis during contraction, buffering interstitial K+ accumulation, which is linked to muscle fatigue during intense exercise. Within this context, we adopted a recently reported methodol...
Diet-induced impairment of skeletal muscle and adipose tissue metabolic homeostasis and its prevention by probiotic administration [0.03%]
饮食引起的骨骼肌和脂肪组织代谢稳态紊乱及其通过益生菌摄入得到的预防措施
Angela Di Porzio,Valentina Barrella,Luisa Cigliano et al.
Angela Di Porzio et al.
Western dietary pattern is one of the main contributors to the increased risk of obesity and chronic diseases, through oxidative stress and inflammation, that are the two key mechanisms targeting metabolic organs, such as skeletal muscle an...
Intracellular cAMP signaling-induced Ca2+ influx mediated by calcium homeostasis modulator 1 (CALHM1) in human odontoblasts [0.03%]
人成牙本质细胞中由钙稳态调节剂1（CALHM1）介导的环磷酸腺苷信号诱导的钙离子流入现象研究
Maki Kimura,Sachie Nomura,Takehito Ouchi et al.
Maki Kimura et al.
In odontoblasts, intracellular Ca2+ signaling plays key roles in reactionary dentin formation and generation of dentinal pain. Odontoblasts also express several Gs protein-coupled receptors that promote production of cyclic AMP (cAMP). Howe...
Lipid signaling: facets of a versatile cell communication strategy in health and disease [0.03%]
脂质信号转导：健康与疾病中一种多功能细胞通讯策略的多个方面
Erich Gulbins,Josef Pfeilschifter
Erich Gulbins
Thomas Lissek
Thomas Lissek
The enhancement of complex physiological functions such as cognition and exercise performance in healthy individuals represents a challenging goal. Adaptive transcription programs that are naturally activated in animals to mediate cellular ...
Cardioprotective effects of H3 receptor activation could be double-sided: insights from isoproterenol-induced cardiac injury [0.03%]
H3受体激活的护心作用可能是双刃剑——异丙肾上腺素诱导的心脏损伤新见解
H Fehmi Özel,Mustafa Özbek,Merve Temel Özden et al.
H Fehmi Özel et al.
Histamine H3 receptors (H3Rs) are known to modulate neurotransmitter release in the nervous system, but their role in cardiac injury remains unclear. The present study aimed to investigate the cardioprotective role of H3Rs in a mouse model ...
Chronic rose oxide and exercise synergistically modulate cardiovascular and autonomic functions in hypertensive rats [0.03%]
慢性玫瑰醇和运动协同调节高血压大鼠心血管及自主神经功能
Juliana A da Silva,Samuel S P Araújo,Ana Flávia M da Silva et al.
Juliana A da Silva et al.
With the alarming rise in cases of arterial hypertension worldwide, there is an urgent need to develop combined therapies to mitigate this scenario. Rose oxide (RO), a monoterpene with anti-inflammatory and hypotensive properties, emerges a...
Causality and scientific explanation of artificial intelligence systems in biomedicine [0.03%]
因果关系与生物医学中人工智能系统的科学解释方法
Florian Boge,Axel Mosig
Florian Boge
With rapid advances of deep neural networks over the past decade, artificial intelligence (AI) systems are now commonplace in many applications in biomedicine. These systems often achieve high predictive accuracy in clinical studies, and in...