The voltage-sensitive cardiac M2 muscarinic receptor modulates the inward rectification of the G protein-coupled, ACh-gated K+ current [0.03%]
电压敏感型心脏M2胆碱能受体调节由G蛋白偶联的乙酰胆碱门控钾电流的内向整流作用
Pedro D Salazar-Fajardo,Iván A Aréchiga-Figueroa,Ana Laura López-Serrano et al.
Pedro D Salazar-Fajardo et al.
The acetylcholine (ACh)-gated inwardly rectifying K+ current (IKACh) plays a vital role in cardiac excitability by regulating heart rate variability and vulnerability to atrial arrhythmias. These crucial physiological contributions are dete...
Glucose-regulated protein 78 in lipid rafts elevates vascular smooth muscle cell proliferation of spontaneously hypertensive rats by controlling platelet-derived growth factor receptor signaling [0.03%]
网格蛋白依赖的脂筏中葡萄糖调节蛋白78通过调控血小板源性生长因子受体信号促进自发性高血压大鼠血管平滑肌细胞增殖
Do-Yoon Kim,Dae Il Hwang,Soo Min Park et al.
Do-Yoon Kim et al.
The multifunctional glucose-regulated protein 78 (GRP78) is known to be differentially expressed in the lipid rafts of vascular smooth muscle cells (VSMCs) from spontaneously hypertensive rats (SHRs) and normal Wistar-Kyoto (WKY) rats. Howe...
Renal expression and urinary excretion of Na+/dicarboxylate cotransporter 1 (NaDC1) in obstructive nephropathy: a candidate biomarker for this pathology [0.03%]
阻塞性肾病的钠/二羧酸盐同向转运体1（NaDC1）在肾脏中的表达及其尿液排泄：作为该疾病生物标志物的候选者
Romina V Campagno,María J Severin,Evangelina C Nosetto et al.
Romina V Campagno et al.
Obstructive nephropathy is characterized by alterations in renal function that depends on the degree and type of obstruction. To increase the knowledge about the physiopathological mechanisms involved in the renal damage associated with bil...
Su-Kyung Shin,Hyun-Woo Cho,Seung-Eun Song et al.
Su-Kyung Shin et al.
Obesity and insulin resistance are considered the main causes of nonalcoholic fatty liver disease (NAFLD), and oxidative stress accelerates the progression of NAFLD. Free fatty acids, which are elevated in the liver by obesity or insulin re...
Transcripts of Kv7.1 and MinK channels and slow delayed rectifier K+ current (IKs) are expressed in zebrafish (Danio rerio) heart [0.03%]
斑马鱼心脏中慢延迟整流钾电流通道Kv7.1和MinK的转录表达
Denis V Abramochkin,Minna Hassinen,Matti Vornanen
Denis V Abramochkin
Zebrafish are increasingly used as a model for human cardiac electrophysiology, arrhythmias, and drug screening. However, K+ ion channels of the zebrafish heart, which determine the rate of repolarization and duration of cardiac action pote...
Larissa M Dorsch,Maike Schuldt,Dora Knežević et al.
Larissa M Dorsch et al.
Mutations in genes encoding sarcomeric proteins are the most important causes of inherited cardiomyopathies, which are a major cause of mortality and morbidity worldwide. Although genetic screening procedures for early disease detection hav...
Hereditary hypophosphatemic rickets with hypercalciuria: pathophysiology, clinical presentation, diagnosis and therapy [0.03%]
遗传性低磷血症性佝偻病伴高钙尿症：发病机制、临床表现、诊断和治疗
Clemens Bergwitz,Ken-Ichi Miyamoto
Clemens Bergwitz
Hereditary hypophosphatemic rickets with hypercalciuria (HHRH; OMIM: 241530) is a rare autosomal recessive disorder with an estimated prevalence of 1:250,000 that was originally described by Tieder et al. Individuals with HHRH carry compoun...
Muriel Auberson,Sophie Stadelmann,Candice Stoudmann et al.
Muriel Auberson et al.
Uric acid (UA) is a metabolite of purine degradation and is involved in gout flairs and kidney stones formation. GLUT9 (SLC2A9) was previously shown to be a urate transporter in vitro. In vivo, humans carrying GLUT9 loss-of-function mutatio...
Loss-of-function of Nav1.8/D1639N linked to human pain can be rescued by lidocaine [0.03%]
与人类疼痛相关的Nav1.8/D1639N功能丧失可被利多卡因解救
Luisa Kaluza,Jannis E Meents,Martin Hampl et al.
Luisa Kaluza et al.
Mutations in voltage-gated sodium channels are associated with altered pain perception in humans. Most of these mutations studied to date present with a direct and intuitive link between the altered electrophysiological function of the chan...
Alyssa Grogan,Aikaterini Kontrogianni-Konstantopoulos
Alyssa Grogan
Obscurins, expressed from the single OBSCN gene, are a family of giant, modular, cytoskeletal proteins that play key structural and regulatory roles in striated muscles. They were first implicated in the development of heart disease in 2007...