Training state and fasting-induced PDH regulation in human skeletal muscle [0.03%]
人类骨骼肌训练状态和饥饿诱导的PDH调节
Anders Gudiksen,Lærke Bertholdt,Tomasz Stankiewicz et al.
Anders Gudiksen et al.
The aim of the present study was to examine the influence of training state on fasting-induced skeletal muscle pyruvate dehydrogenase (PDH) regulation, including PDH phosphorylation. Trained and untrained subjects, matched for skeletal musc...
Calcium store refilling and STIM activation in STIM- and Orai-deficient cell lines [0.03%]
STIM和Orai缺陷细胞系中的钙库再充及STIM激活
Sisi Zheng,Lijuan Zhou,Guolin Ma et al.
Sisi Zheng et al.
Mediated through the combined action of STIM proteins and Orai channels, store-operated Ca2+ entry (SOCE) functions ubiquitously among different cell types. The existence of multiple STIM and Orai genes has made it difficult to assign speci...
PTPN6 regulates the cell-surface expression of TRPM4 channels in HEK293 cells [0.03%]
PTPN6调节HEK293细胞中TRPM4通道的细胞表面表达
Dong Kun Lee,Jung Yeon Park,Jae Cheal Yoo et al.
Dong Kun Lee et al.
Transient receptor-potential, cation channel, subfamily M, member 4 (TRPM4) channels regulate a variety of physiological and pathological processes; however, their roles as functional channels under diverse conditions remain unclear. In thi...
The role of the mitochondrial calcium uniporter (MCU) complex in cancer [0.03%]
线粒体钙单向转运蛋白(MCU)复合物在癌症中的作用
Adina Vultur,Christine S Gibhardt,Hedwig Stanisz et al.
Adina Vultur et al.
The important role of mitochondria in cancer biology is gaining momentum. With their regulation of cell survival, metabolism, basic cell building blocks, and immunity, among other functions, mitochondria affect not only cancer progression b...
Distinct patterns of exocytosis elicited by Ca2+, Sr2+ and Ba2+ in bovine chromaffin cells [0.03%]
钙离子、锶离子和钡离子引发牛肾上腺嗜铬细胞不同模式的胞外运输反应路径及分子机制研究
Andrés M Baraibar,Ricardo de Pascual,Marcial Camacho et al.
Andrés M Baraibar et al.
Three divalent cations can elicit secretory responses in most neuroendocrine cells, including chromaffin cells. The extent to which secretion is elicited by the cations in intact depolarized cells was Ba2+ > Sr2+ ≥ Ca2+, contrasting with t...
Sarcopenia in a mice model of chronic liver disease: role of the ubiquitin-proteasome system and oxidative stress [0.03%]
慢性肝病小鼠模型中的肌少症：泛素-蛋白酶体系统和氧化应激的作用
Fabián Campos,Johanna Abrigo,Francisco Aguirre et al.
Fabián Campos et al.
Sarcopenia is the loss of muscle mass and strength produced by aging or secondary to chronic diseases such as chronic liver disease (CLD). Although not all types of sarcopenia involve the same features, the most common are decreased fiber d...
Lucile Noyer,Guillaume P Grolez,Natalia Prevarskaya et al.
Lucile Noyer et al.
While originally cloned from the prostate in 2001, transient receptor potential, melastatin member 8 (TRPM8) has since been identified as the cold/menthol receptor in the peripheral nervous system. This discovery has led to hundreds of stud...
Cardiospecific deletion of αE-catenin leads to heart failure and lethality in mice [0.03%]
心脏特异性删除αE-连环蛋白导致小鼠心力衰竭和致死性
Volodymyr V Balatskyi,Larysa L Macewicz,Ana-Maria Gan et al.
Volodymyr V Balatskyi et al.
αE-catenin is a component of adherens junctions that link the cadherin-catenin complex to the actin cytoskeleton. The signaling function of this protein was recently revealed. In the present study, we investigated the role of αE-catenin i...
András Spät,Gergő Szanda
András Spät
The biological effects of physiological stimuli of adrenocortical glomerulosa cells are predominantly mediated by the Ca2+ and the cAMP signal transduction pathways. The complex interplay between these signalling systems fine-tunes aldoster...
Expression and function of Anoctamin 1/TMEM16A calcium-activated chloride channels in airways of in vivo mouse models for cystic fibrosis research [0.03%]
TMEM16A钙激活氯离子通道在小鼠囊性纤维化研究体内模型气道中的表达与功能作用研究
Anne Hahn,Johanna J Salomon,Dominik Leitz et al.
Anne Hahn et al.
Physiological processes of vital importance are often safeguarded by compensatory systems that substitute for primary processes in case these are damaged by gene mutation. Ca2+-dependent Cl- secretion in airway epithelial cells may provide ...