TRPA1 channels: expression in non-neuronal murine lung tissues and dispensability for hyperoxia-induced alveolar epithelial hyperplasia [0.03%]
瞬时受体电位锚定阳离子通道A1(TRPA1)通道在小鼠非神经肺组织中的表达及其在高氧诱导的肺泡上皮细胞增生中的作用研究
Martina Kannler,Robin Lüling,Ali Önder Yildirim et al.
Martina Kannler et al.
Transient receptor potential A1 (TRPA1) channels were originally characterized in neuronal tissues but also identified in lung epithelium by staining with fluorescently coupled TRPA1 antibodies. Its exact function in non-neuronal tissues, h...
Alex M Dopico,Anna N Bukiya,Jonathan H Jaggar
Alex M Dopico
Ion channels in vascular smooth muscle regulate myogenic tone and vessel contractility. In particular, activation of calcium- and voltage-gated potassium channels of large conductance (BK channels) results in outward current that shifts the...
Critical role of angiotensin II type 2 receptors in the control of mitochondrial and cardiac function in angiotensin II-preconditioned rat hearts [0.03%]
血管紧张素Ⅱ预处理大鼠心脏中血管紧张素Ⅱ受体Ⅱ型在调控线粒体和心室功能中的关键作用
Rebeca E Nuñez,Sabzali Javadov,Nelson Escobales
Rebeca E Nuñez
Angiotensin II preconditioning (APC) involves an angiotensin II type 1 receptor (AT1-R)-dependent translocation of PKCε and survival kinases to the mitochondria leading to cardioprotection after ischemia-reperfusion (IR). However, the role...
Drug transporter expression profiling in a three-dimensional kidney proximal tubule in vitro nephrotoxicity model [0.03%]
药物转运蛋白在体外肾毒性模型三维肾脏近端小管中的表达谱分析
Dorina Diekjürgen,David W Grainger
Dorina Diekjürgen
Given currently poor toxicity translational predictions for drug candidates, improved mechanistic understanding underlying nephrotoxicity and drug renal clearance is needed to improve drug development and safety screening. Therefore, better...
Regional increase in ROS within stretched region exacerbates arrhythmias in rat trabeculae with nonuniform contraction [0.03%]
拉伸区域的ROS增加会加剧心肌非均匀收缩中 arrhythmias 的发生
Masahito Miura,Yuhto Taguchi,Tetsuya Handoh et al.
Masahito Miura et al.
In diseased hearts, impaired muscle within the hearts is passively stretched by contractions of the more viable neighboring muscle during the contraction phase. We investigated whether in the myocardium with nonuniform contraction such pass...
Hydrogen sulphide facilitates exocytosis by regulating the handling of intracellular calcium by chromaffin cells [0.03%]
氢硫酸盐通过调节肾上腺素髓质嗜铬细胞的细胞内钙来促进胞吐作用
Ricardo de Pascual,Andrés M Baraibar,Iago Méndez-López et al.
Ricardo de Pascual et al.
Gasotransmitter hydrogen sulphide (H2S) has emerged as a regulator of multiple physiological and pathophysiological processes throughout. Here, we have investigated the effects of NaHS (fast donor of H2S) and GYY4137 (GYY, slow donor of H2S...
Karolina Najder,Boris Musset,Otto Lindemann et al.
Karolina Najder et al.
Neutrophil granulocytes are exposed to widely varying microenvironmental conditions when pursuing their physiological or pathophysiological functions such as fighting invading bacteria or infiltrating cancer tissue. Examples for harsh envir...
Mammalian cold TRP channels: impact on thermoregulation and energy homeostasis [0.03%]
哺乳动物冷TRP通道：对体温调节和能量稳态的影响
Rosa Señarís,Purificación Ordás,Alfonso Reimúndez et al.
Rosa Señarís et al.
Body temperature regulation is a fundamental homeostatic function in homeothermic animals. It is governed by the central nervous system that integrates temperature signals from internal body structures and the skin and provides efferent res...
Methylmercury reduces synaptic transmission and neuronal excitability in rat hippocampal slices [0.03%]
甲基汞抑制大鼠海马脑片的突触传递和神经元兴奋性
J Gutiérrez,A M Baraibar,E Albiñana et al.
J Gutiérrez et al.
In a previous study, we pointed out that the neurotoxic action evoked by methylmercury (MeHg), a potent environmental pollutant responsible for fatal food poisoning, is associated with alterations of cellular excitability by irreversible bl...
Yasuo Mori,Thomas Voets
Yasuo Mori