AT1 receptors play a role in sepsis-induced vasoplegia by increasing iNOS expression in the perivascular adipose tissue [0.03%]
AT1受体通过增加血管周围脂肪组织中的iNOS表达在脓毒症诱导的血管麻痹中发挥作用
Wanessa M C Awata,Gustavo F Pimenta,Thales M H Dourado et al.
Wanessa M C Awata et al.
Sepsis enhances the anticontractile effect of perivascular adipose tissue (PVAT), which contributes to a reduced response to vasoconstrictor agents. In the early stages of sepsis, the renin-angiotensin-aldosterone system (RAAS) is activated...
Pregnancy induces intestinal epithelial elongation and estriol-associated activation of the Hippo signaling pathway in a mouse model [0.03%]
妊娠诱导小鼠模型肠道上皮细胞伸长和雌三醇相关Hippo信号通路激活
Niklas Fritz Gängler,Cathrine Knoblauch,Franziska Hill et al.
Niklas Fritz Gängler et al.
During pregnancy and weaning, the intestinal tract undergoes adaptations on different levels, including altered immune cell frequencies and epithelial changes. We could show in a mouse model that the overall area (crypt-villus axis length a...
Armin Kurtz,Kai-Uwe Eckardt,Max Gassmann et al.
Armin Kurtz et al.
Ryanodine receptor stabilizer S-107 rescues slow-type rat soleus muscle function after 7-day hindlimb unloading [0.03%]
肌松剂S-107通过稳定ryanodine受体修复地面束缚大鼠腓肠肌慢收缩型运动单位的功能损伤
Daria A Sidorenko,Roman O Bokov,Gleb V Galkin et al.
Daria A Sidorenko et al.
During periods of muscle disuse, calcium accumulates in the myoplasm of slow-tonic muscle fibers, leading to multiple negative consequences for muscle function. Leaky ryanodine receptors (RyRs) could contribute to this excessive accumulatio...
Voltage-gated Na+ channels: key players in the early tumorigenesis of breast cancer [0.03%]
电压门控钠通道：乳腺癌早期肿瘤发生的关键因素
Paula Rhana,Flávia Carvalho Aguiar,Diego Santos Souza et al.
Paula Rhana et al.
Voltage-gated Na+ channels (VGSCs) are recognized for their roles in cancer biology, particularly in promoting tumor aggressiveness. However, their presence and functional significance in early-stage breast cancer remain poorly understood. ...
Molecular determinants of HERG potassium channel blockade by domiphen bromide and benzethonium chloride [0.03%]
溴化多非フェンとベンゼチオン
Feng Tang,Zuoxian Lin,Rongqi Huang et al.
Feng Tang et al.
Domiphen bromide (DMP) and benzethonium chloride (BZT) are synthetic quaternary ammonium compounds widely used as disinfectants. Both agents are potent inhibitors of the human ether-à-go-go-related gene (HERG) potassium channel, a key cont...
Elabela alleviates ischemia/reperfusion-induced hepatic and remote organ injury by inhibiting oxidative stress in rats [0.03%]
Elabela通过抑制氧化应激缓解大鼠缺血再灌注所致的肝脏和远处器官损伤
Ayşegül Bahar Özocak,Leyla Semiha Şen,Leman Arslan Arıtürk et al.
Ayşegül Bahar Özocak et al.
Hepatic injury is one of the most critical problems in major liver surgeries, trauma, sepsis or shock. The novel Elabela (ELA) peptide was shown to exert protective effects against cardiac and renal injury. We hypothesized that ELA could al...
Jana Pourová,Patrícia Dias,Milan Pour et al.
Jana Pourová et al.
Tissue perfusion is acutely regulated by the changes in the vascular tone resulting in vasodilatation or vasoconstriction (there are also long-term changes in tissue perfusion, effectively accomplished by vascular remodeling). Even though v...
Oxygen dissociation curve inflection point during incremental exercise: a trigger for the Bohr effect [0.03%]
递增运动时氧解离曲线拐点：Bohr效应的触发因素
Holger H Burchert,William W Stringer,Ranjan K Dash
Holger H Burchert
We previously hypothesized that the inflection point of the oxygen dissociation curve (ODC) is linked to the gas exchange threshold (GET) during cardiopulmonary exercise testing. This hypothesis was supported by femoral venous blood gas dat...
Presynaptic maturation of inhibitory connections onto vasoactive intestinal polypeptide-expressing GABAergic interneurons in the mouse barrel field [0.03%]
小鼠 barrels 神经元中抑制性突触前成熟度的增加 sourceMapping：该句子的主要内容是关于“血管活性肠肽表达的GABA能中间神经元”的一个研究，具体来说就是这些中间神经元中的“抑制性连接”在“突触前成熟度”的变化。这里的“小鼠 barrels 神经元”可以理解为一种特定区域或类型的神经元，而不是字面意思的“桶状皮层”。因此，根据这个逻辑，将其翻译成中文如下：
“血管活性肠肽表达的GABA能中间神经元中抑制性突触前成熟度的小鼠 barrels 神经元研究”
但是为了更加通俗易懂，也可以简化为：
“小鼠血管活性肠肽 GABA 能中间神经元中的抑制性突触前成熟度变化”
Clara A Simacek,Sergei Kirischuk,Thomas Mittmann
Clara A Simacek
Vasoactive intestinal polypeptide-expressing inhibitory interneurons (VIP-INs) in the adult barrel cortex are crucial for mediating active whisking (AW) by disinhibiting pyramidal neurons. Past studies have investigated the development of V...