Lateral hypothalamic area high-frequency deep brain stimulation rescues memory decline in aged rat: behavioral, molecular, and electrophysiological study [0.03%]
侧导乐状区高频深部脑刺激可逆转老龄大鼠记忆衰退：行为、分子及电生理学研究
Abdelaziz M Hussein,Ahmed F Abouelnaga,Walaa Obydah et al.
Abdelaziz M Hussein et al.
To examine the effect of DBS of the lateral hypothalamic area (LHA) on age-related memory changes, neuronal firing from CA1, oxidative stress, and the expression of Hsp70, BDNF, and synaptophysin. 72 male rats were randomly allocated into 6...
Combined exercise-induced modulation of Notch pathway and muscle quality in senescence-accelerated mice [0.03%]
联合运动介导的Notch信号通路和肌肉质量在衰老小鼠中的调节作用研究
Ana P Pinto,Ângelo Augusto J Sarni,Maria Eduarda A Tavares et al.
Ana P Pinto et al.
The Notch signaling pathway is crucial for skeletal muscle development, regeneration, inflammation, and aging. This study investigated the association between interleukin-10 (IL-10) and the Notch pathway in C2C12 cells, as well as explored ...
Correction to: Estrogen hindrance escalates inflammation and neurodegeneration in the hippocampal regions of collagen induced arthritis female Sprague-Dawley rats [0.03%]
Correction to：雌性SD胶原诱导的类风湿关节炎大鼠脑内雌激素水平下降加重海马区炎症和神经退行性病变
Zuo Hao Lee,Wong Siew Tung,Kabileshvaran A/L Jana Santhiran et al.
Zuo Hao Lee et al.
25-Hydroxycholesterol modulates synaptic vesicle endocytosis at the mouse neuromuscular junction [0.03%]
25-羟基胆固醇调节小鼠神经肌肉接头的突触囊泡胞吞作用
Eva A Kuznetsova,Guzalia F Zakirjanova,Andrei N Tsentsevitsky et al.
Eva A Kuznetsova et al.
Many synaptic vesicles undergo exocytosis in motor nerve terminals during neuromuscular communication. Endocytosis then recovers the synaptic vesicle pool and presynaptic membrane area. The kinetics of endocytosis may shape neuromuscular tr...
Lessons from a model: early glucagon dysfunction in type 2 diabetes [0.03%]
模型的启示：2型糖尿病患者早期胰高血糖素功能障碍
Shawn Duckett,Patrick E MacDonald
Shawn Duckett
Spatially dependent tissue distribution of thyroid hormones by plasma thyroid hormone binding proteins [0.03%]
血浆甲状腺激素结合蛋白依赖空间的组织分布甲状腺激素
Anish D Bagga,Brian P Johnson,Qiang Zhang
Anish D Bagga
Plasma thyroid hormone (TH) binding proteins (THBPs), including thyroxine-binding globulin (TBG), transthyretin (TTR), and albumin (ALB), carry THs to extrathyroidal sites, where THs are unloaded locally and then taken up via membrane trans...
Competing effects of activation history on force and cytosolic Ca2+ in intact single mice myofibers [0.03%]
激活史对完整单肌纤维力和细胞内钙离子的竞争效应
Alexander M Zero,Charles L Rice,Leonardo Nogueira
Alexander M Zero
The purpose was to investigate the changes in cytosolic Ca2+ and force output during post-tetanic potentiation (PTP) during pre-fatigue and during prolonged low-frequency force depression (PLFFD) following fatigue. Intact single myofibers f...
Hyperosmolality activates polycystin-2 and TRPM4 in renal primary cilium [0.03%]
高渗透活化肾原初纤毛中的多囊肿蛋白-2和TRPM4
Steven J Kleene
Steven J Kleene
Autosomal dominant polycystic kidney disease (ADPKD) is a debilitating disease characterized by renal cysts. It arises from mutations in proteins expressed in part in the primary cilia of renal epithelial cells. One of these, polycystin-2 (...
GQ style: a multipronged therapeutic approach to pulmonary arterial hypertension [0.03%]
高流量吸入疗法治疗肺动脉高压患者的效果观察
Wolfgang M Kuebler
Wolfgang M Kuebler