Integrated bioinformatics, single-cell analysis, and experimental validation identify quercetin as a potential therapeutic candidate for intervertebral disc degeneration [0.03%]
整合生物信息学、单细胞分析和实验验证鉴定出檞皮素可能是治疗椎间盘退变的潜在药物候选物
Fuduo Zhang,Yingqiu Yang,Xiaoyan Gou et al.
Fuduo Zhang et al.
Intervertebral disc degeneration (IVDD) is a major pathological basis of low back pain, but its molecular mechanisms remain incompletely understood. Identifying key genes and potential therapeutic compounds may provide new insights into the...
Acute and sub-acute toxicity assessment of tetrodotoxin in Sprague-Dawley rats following intramuscular injection [0.03%]
美乐胺肌肉注射急性及亚急性毒性研究
Lijun Ren,Kexuan Zhou,Hao Xuan et al.
Lijun Ren et al.
Tetrodotoxin (TTX) is a potent neurotoxin with therapeutic potential, particularly in the fields of analgesia, cancer pain treatment, and drug addiction therapy. However, its high toxicity and lack of antidotes limit its clinical applicatio...
Ulcerative colitis: from molecular pathophysiology to management and the emerging role of natural and pharmacological drug candidates [0.03%]
溃疡性结肠炎：从分子病理生理学到管理以及天然和药理药物候选物的作用越来越重要
Ehab E Sharata,Taha Bakry,Hager Mohamed et al.
Ehab E Sharata et al.
Ulcerative colitis (UC) is a chronic, relapsing, immune-mediated inflammatory disease of the colonic mucosa that imposes a substantial and growing global health burden. The pathophysiological basis of UC encompasses a multifactorial interpl...
MTA-NPs induce preferential cytotoxicity, oxidative DNA damage, and mitochondrial apoptosis in human Hep-G2 hepatocellular carcinoma cells [0.03%]
MTA-NPs诱导人Hep-G2肝癌细胞的特异性细胞毒性、氧化DNA损伤及线粒体凋亡
Hanan R H Mohamed,Sara A Diab,Jana W Mofadal et al.
Hanan R H Mohamed et al.
Hepatocellular carcinoma is one of the most aggressive and fatal malignancies worldwide, and the limited efficacy and severe toxic side effects of conventional chemotherapy emphasize the urgent need for safer and more effective therapeutic ...
Promising natural agents in psychopharmacology described by Rhazes in Al-Hawi and Liber Almansoris: a ninth-century paradigm [0.03%]
拉齐《医学大全》和《阿爾曼索里书》中所述的精神药理学中的天然药物及其在九世纪的范式地位
Hamed Ahansazan,Mohammad Hossein Ayati,Fuat Ince et al.
Hamed Ahansazan et al.
The synthesis of psychopharmaceuticals in the twentieth century marked the beginning of modern psychopharmacology, replacing earlier first-line psychiatric management that relied on psychosurgery, physical restraint, or administering narcot...
Interplay between systemic immune-metabolic signatures and endometrial immune profiles in women with recurrent pregnancy loss [0.03%]
系统性免疫代谢标志物与反复妊娠丢失女性子宫内膜免疫图谱之间的相互作用
Amin Kamrani,Shiva Pourvahdani,Mohammadbagher Pirouzpanah et al.
Amin Kamrani et al.
Recurrent pregnancy loss (RPL) is a complex disorder fundamentally linked to immune dysregulation at the maternal-fetal interface. While endometrial immune profiling provides critical diagnostic insights for managing RPL, its clinical appli...
Emerging role of plant-based compounds as ferroptosis modulators in breast cancer [0.03%]
植物源性化合物作为乳腺癌铁死亡调节剂的新兴作用
Pratibha Pandey,Nasar Mallick,Sajad Ali et al.
Pratibha Pandey et al.
Ferroptosis is a specialized form of regulated cell death that is dependent on intracellular iron and is characterized by excessive lipid peroxidation, accumulation of lipid peroxides, and increased intracellular iron levels. This process i...
Novel fenoterol derivatives as suppressors of ERK1/2 phosphorylation in melanoma [0.03%]
新型酚托特罗衍生物作为黑色素瘤中ERK1/2磷酸化的抑制剂
Jakub Wójcik,Sylwia Wnorowska,Weronika Miziewicz et al.
Jakub Wójcik et al.
Melanoma is a highly aggressive cancer with limited therapeutic options. In melanoma cell lines, β2AR activation leads to the suppression of pro-proliferatory MAPK/ERK signaling. This suggests that fenoterol, a potent β2AR agonist, can be...
Philipp Friedrich Georg Ried,Roland Seifert
Philipp Friedrich Georg Ried
Drug-induced gingival overgrowth (DIGO) is becoming an increasingly important issue due to high prescription rates of inducing pharmaceuticals. Therefore, the main focus of this study was to determine what experiences dentists in Germany ha...
Disproportionality analysis of drug-associated tinnitus safety signals: a 43-year pharmacovigilance study [0.03%]
基于药物不良反应报告系统的药物性耳鸣 disproportionality 分析（1976-2018）
Nagalakshmi Narasimhaswamy,Shyamala Ganesan,Basavaraj Poojar
Nagalakshmi Narasimhaswamy
Drug-induced tinnitus is a prevalent yet under-characterised adverse drug reaction. No prior study has systematically screened the FDA Adverse Event Reporting System (FAERS) for drug-tinnitus disproportionality signals using a rigorous, ded...