Pharmacological evolution of natural product-based and chemically engineered autophagy-modulating strategies in neurodegenerative diseases: a bibliometric mapping analysis (2006-2025) [0.03%]
基于天然产物和化学工程技术的自噬调节策略在神经退行性疾病中的药理学演变（2006-2025）：文献计量分析
Menghao Liu,Shumin Ye
Menghao Liu
Pharmacological modulation of autophagy has become an important neuropharmacological strategy for neurodegenerative diseases. However, the comparative development of natural product-based and chemically engineered autophagy-modulating strat...
Apoptosis-inducing potential of tilorone dihydrochloride in triple-negative breast cancer: in silico and in vitro evidences [0.03%]
tilorone二盐酸化合物通过体外和计算机模拟证据诱导三阴性乳腺癌细胞凋亡的潜力
Abu Sufiyan Chhipa,Valentina Boscaro,Margherita Gallicchio et al.
Abu Sufiyan Chhipa et al.
Tilorone is an antiviral agent with interferon-inducing properties. The present study focused on evaluating the apoptosis-inducing effects of tilorone in triple-negative breast cancer (TNBC) using in silico and in vitro models. Molecular do...
Integrating network toxicology, machine learning, and single-cell sequencing systems to analyze autophagy core genes in lung adenocarcinoma [0.03%]
整合网络毒理学、机器学习和单细胞测序系统分析肺腺癌自噬核心基因
Jie Yan,Shu Gong,Jing Yuan et al.
Jie Yan et al.
The heterogeneity and complex tumor microenvironment of lung adenocarcinoma lead to poor prognosis. Autophagy, as a key cellular process, interacts with tumor immune infiltration and jointly affects the progression of lung adenocarcinoma, b...
Editorial Expression of Concern: Antiviral and neuroprotective activity of diallyl disulfide in Japanese encephalitis virus‑challenged SH‑SY5Y cells: a post‑treatment approach for greater specificity [0.03%]
撤稿声明：日本脑炎病毒攻击SH-SY5Y细胞后采用大蒜素进行抗病毒和神经保护作用的治疗方案特异性强于预防性用药
Rishu Kumar,Selamu Kebamo Abate,Vaishali Yadav et al.
Rishu Kumar et al.
GraESM-FuseDTA: adaptive gated multimodal fusion of graph neural networks and protein language models for robust drug-target affinity prediction [0.03%]
基于图神经网络和蛋白质语言模型自适应门控多模态融合的稳健药物-靶点亲和力预测方法(GraESM-FuseDTA)
Jun-Wen He
Jun-Wen He
Accurate drug-target affinity prediction is essential for virtual screening, lead compound prioritization, and drug repositioning, especially under cold-start scenarios involving unseen compounds, unseen targets, or unseen drug-target combi...
Protective effects of ginseng against reproductive injury: mechanisms and research progress [0.03%]
人参对生殖损伤的保护作用：机制和研究进展
Chao Jiang,Wei Li,Ying-Ping Wang
Chao Jiang
Reproductive injury is a core pathological process leading to gamete dysfunction, gonadal structural damage, and impaired reproductive capacity. Basic research has revealed that its pathogenesis involves a complex regulatory network of oxid...
Unveiling the pharmacological landscape of geniposidic acid: mechanisms of action, therapeutic benefits, and scientific challenges [0.03%]
石杉苷酸的药理作用机制、治疗益处及科学挑战展望
Lakshmi Narayana Ellutla,Ashutosh Rajput,Bidya Dhar Sahu
Lakshmi Narayana Ellutla
Geniposidic acid (GPA) is a bioactive iridoid glycoside mainly found in many traditional medicinal plants, including Eucommia ulmoides and Gardenia jasminoides. These plants are also commonly used in traditional diets and herbal teas throug...
β1- and β2-adrenergic receptor mediated spontaneous contractions and ryanodine receptor channel opening in human failing heart [0.03%]
人类心力衰竭心脏中肾上腺素受体介导的自发收缩及ryanodine受体通道开放现象
Weilan Mo,Nicole A Beard,Katherine T Gillette-Browne et al.
Weilan Mo et al.
In heart failure, β-adrenergic receptor (β-AR)-Gsα-cAMP-protein kinase A (PKA) signalling predisposes to delayed-afterdepolarisation-mediated arrhythmias. Phosphodiesterases (PDEs) hydrolyse cAMP, and PDE3 restrains β1-AR, β2-AR-mediat...
Effects of tadalafil on endothelial, angiogenic, metabolic, and microRNA biomarker profiles in sexually active men with BPH and erectile dysfunction: a randomized controlled trial [0.03%]
他达拉非对良性前列腺增生合并勃起功能障碍的性活跃男性内皮细胞、血管生成、代谢和微小核糖核酸生物标志物谱型的影响：随机对照试验
Ahmed Abomandour,Ehab A M El-Shoura,Basem A Fathi et al.
Ahmed Abomandour et al.
Benign prostatic hyperplasia (BPH) is increasingly linked to endothelial dysfunction, angiogenic activation, chronic inflammation, and metabolic dysregulation. This randomized controlled trial evaluated the dose-dependent effects of tadalaf...
Targeting early pulmonary fibrosis with bone marrow mesenchymal stem cells and their derived exosomes: a comparative study of inhalation versus injection delivery in bleomycin-induced rat lung injury [0.03%]
骨髓间充质干细胞及其衍生的外泌体在早期肺纤维化治疗中的作用及吸入和注射两种给药方式的比较：以博来霉素致伤大鼠模型为例
Meral Hakam,Ismail Mostafa,Eman I Hassanen et al.
Meral Hakam et al.
Considering the increasing prevalence of pulmonary fibrosis (PF) and the increased exposure to risk factors contributing to its development, this study utilizes the bleomycin (BLM)-induced PF model to explore the potential early therapeutic...