Granulomatous amoebic encephalitis: pathogenesis, diagnostic advances, therapeutic challenges, and emerging treatment strategies [0.03%]
肉芽肿性阿米巴脑炎：发病机制、诊断进展、治疗挑战和新兴的治疗方法
Megha Gautham,Poluri Koteswari
Megha Gautham
Granulomatous amoebic encephalitis (GAE) is a rare but highly fatal central nervous system infection caused primarily by Acanthamoeba spp. and Balamuthia mandrillaris. Delayed diagnosis and the absence of standardized treatment protocols co...
Immunomodulatory effect of stress hormones on porcine neutrophil functions during Actinobacillus pleuropneumoniae infection [0.03%]
应激激素对猪肺疫病程中多形核白细胞功能调控的影响机制研究
Marta C Bonilla,Simon Lassnig,Michael Wendt et al.
Marta C Bonilla et al.
Stress contributes to disease outcomes and can influence the signaling and interactions of immune cells. This study aimed to evaluate the influence of three selected stress hormones cortisol, epinephrine and norepinephrine, at in vivo-relev...
Human ex vivo comparison of Escherichia coli and Pseudomonas aeruginosa lipopolysaccharide-induced immune responses and cefiderocol effects in whole blood [0.03%]
人外植体中希瓦氏菌脂多糖诱导的免疫反应及全血中赛西德米冬的作用效果与大肠杆菌和绿脓杆菌脂多糖诱导的免疫反应及全血中的作用效果的比较
Lena Pracher,Anselm Jorda,Sabine Eberl et al.
Lena Pracher et al.
Immune dysregulation is central in bacterial sepsis with lipopolysaccharide (LPS) of gram-negative bacteria acting as a key component in innate immune activation. Modulation of the host response by potential immunomodulatory agents may conf...
Comparative Study
Medical microbiology and immunology. 2026 Jul 27;215(1):20. DOI:10.1007/s00430-026-00883-1 2026
Candida albicans hyphae modulate Staphylococcus aureus cell-free supernatant during dual biofilm growth to drive molecular signatures of oral dysplasia [0.03%]
白色念珠菌菌丝在双重生物膜生长过程中调节金黄色葡萄球菌的代谢产物，驱动口腔粘膜发育不良的分子标志物表达
Freddy H Marin-Dett,Mateus P Grejo,Valéria Valente et al.
Freddy H Marin-Dett et al.
Microbes frequently exist as biofilm-embedded multi-species communities where their interactions may establish or exacerbate chronic infection. Recently, fungi and bacteria have been associated with various human tumor microenvironments, su...
Targeting phospholipase A2 with arachidonyl trifluoromethyl ketone modulates macrophage activation during Japanese encephalitis virus infection [0.03%]
日炎病毒感作期间磷脂酶A2调控宏噬细胞活化：以花生四烯三氟甲基酮为作用物
Alok Kumar,Gajendra Singh,Francesco Zonta et al.
Alok Kumar et al.
Phospholipase A2 (PLA2) is a crucial enzyme in lipid metabolism and inflammatory signaling, playing a significant role in macrophage activation and neuroinflammation. However, its role in Japanese encephalitis virus (JEV)-mediated immune re...
Epitope mapping and conservation of antigens from the Multi-Cruzi immunoassay platform [0.03%]
多克鲁齐免疫分析平台抗原的表位作图及保守性研究
Eric Dumonteil,Claudia Herrera
Eric Dumonteil
Infection with the protozoan parasite Trypanosoma cruzi can lead to Chagas disease, and diagnosis of infection mostly relies on serological testing, although no gold standard exists. The evaluation of treatment efficacy is also challenging ...
Unique molecular profiling of monocyte responses to a high dose of DENV-NS1 reflected the effect of NS1 on hemostasis [0.03%]
独特的单核细胞分子谱分析反映DENV-NS1高剂量下NS1对凝血系统的影响
Khwankhao Saisingha,Chernkhwan Kaofai,Naphak Modhiran et al.
Khwankhao Saisingha et al.
The pathogenesis of dengue is complex and requires further study. Infection with the dengue virus can lead to severe dengue, in which patients experience severe plasma leakage and excessive bleeding. The dengue virus non-structural protein ...
Simultaneous quantification of anti-Spike IgG subclasses against various SARS-CoV-2 variants using a multiplex serological assay [0.03%]
一种用于同时定量针对各种SARS-CoV-2变异株的抗刺突蛋白IgG亚类的多重血清学检测方法
Marie L Bischof,Pascal Irrgang,Matthias Tenbusch et al.
Marie L Bischof et al.
Recent research indicates that the composition of serum anti-SARS-CoV-2 Spike IgG subclass antibodies changes upon repeated exposure to viral Spike. These antibody subclass dynamics were suggested to impact adaptive immune responses and pro...
Intrauterine exposure to HBsAg attenuates the immune response to hepatitis B vaccine via the miR-155-5p/MyD88 axis of DCs in mouse pups [0.03%]
宫内接触HBsAg通过小鼠树突状细胞的miR-155-5p/MyD88轴削弱乙肝疫苗免疫应答
Xufeng Cui,Jia Lian,Yangle Sun et al.
Xufeng Cui et al.
Acute COVID-19 is associated with altered CD8 T-cells indicative of impaired ability to control Epstein-Barr virus reactivation [0.03%]
急性COVID-19与CD8T细胞改变相关，表明其控制EB病毒再激活的能力受损
Ulrik Stervbo,Moritz Anft,Krystallenia Paniskaki et al.
Ulrik Stervbo et al.
Increasing evidence suggests that reactivation of latent EBV in patients with COVID-19 may be linked to the development of post-acute sequelae of COVID-19, colloquially known as Long COVID. However, the reason for this co-occurrence of prim...