A potent protein vaccines OmpW induces strong protective immunity against Klebsiella pneumoniae in a mouse model [0.03%]
一种强有力的蛋白疫苗OmpW可诱导小鼠肺炎克雷伯氏菌感染的强力保护性免疫反应
Ting Huang,Siyou Che,Hong Zhang et al.
Ting Huang et al.
Isohemagglutinins exhibit synergistic polyreactivity toward Streptococcus pneumoniae surface antigens: implications for broad-spectrum reactivity of human antibodies [0.03%]
异型血凝素对肺炎链球菌表面抗原的协同多反应性：人类抗体广谱反应性的意义
Jens Magnus Bernth Jensen,Ole Schmeltz Søgaard,Mikkel Steen Petersen et al.
Jens Magnus Bernth Jensen et al.
Synergistic polyreactivity of antibodies—where distinct oligo- or polyreactive clones combine to enable broad-spectrum antigen binding—was recently demonstrated for human anti-galactose-α-1,3-galactose (αGal) antibodies. However, it rem...
A novel TamA + LtgC bivalent vaccine induces potent immunogenic and bactericidal antibodies against Neisseria gonorrhoeae [0.03%]
一种新的TamA+LtgC二联疫苗可诱导针对淋病奈瑟氏球菌的强效免疫和杀菌型抗体
Narjes Noori Goodarzi,Soheila Ajdary,Mahdi Torkamaneh et al.
Narjes Noori Goodarzi et al.
The role of ciliary function in airway epithelial defense against Pseudomonas aeruginosa [0.03%]
纤毛功能在气道上皮防御铜绿假单胞菌中的作用
Nina Boeck,Philipp Grubwieser,Rudolf Glueckert et al.
Nina Boeck et al.
Respiratory cilia play a crucial role in clearing pathogens from the airway, and understanding how Pseudomonas aeruginosa (PA) impairs their function is essential for developing targeted therapies to enhance airway epithelial defense and ha...
A comprehensive multi-epitope recombinant protein strategy for accurate serological detection of Toxoplasma gondii infection [0.03%]
一种全面的多抗原表位重组蛋白策略 用于准确检测Toxoplasma gondii感染
Amirreza Javadi Mamaghani,Maryam Karimi,Ali Haghighi et al.
Amirreza Javadi Mamaghani et al.
Toxoplasma gondii is a globally prevalent zoonotic parasite responsible for toxoplasmosis. Accurate serological diagnosis remains challenging due to the lack of standardized, high-performance antigens. In this study, we designed a recombina...
Genotypic investigation of Mycobacterium leprae in patients with relapsing leprosy in Mato Grosso, Brazil [0.03%]
巴西马托格罗索州复发型麻风病患者中麻风分枝杆菌的基因型调查研究
Roque Rafael de Oliveira Neto,Agenor de Castro Moreira Dos Santos Júnior,Brenno Vinicius Martins Henrique et al.
Roque Rafael de Oliveira Neto et al.
Commensal Peptoniphilus harei induce activation of monocytes via TLR2/CD14 signalling in whole blood [0.03%]
肠杆菌肽拟嗜蛋白菌通过TLR2/CD14信号激活全血中的单核细胞
Tobias Schmidt,Inga-Maria Frick,Lotta Happonen et al.
Tobias Schmidt et al.
Myeloid cells, such as monocytes, are central in the immune response to infections. However, limited knowledge exists regarding the inflammatory response to Gram-positive anaerobic cocci (GPAC).To explore the ability of GPACs to induce mono...
YopP modulates bacterial virulence and systemic dissemination in Peyer´s patches during murine Yersinia enterocolitica infection [0.03%]
YopP调节耶尔森菌在小鼠肠集合淋巴结感染过程中的细菌致病性和系统播散性
Juan Eduardo Silva,Ricardo Javier Eliçabe,Roberto Carlos Davicino et al.
Juan Eduardo Silva et al.
Yersinia enterocolitica (Ye) typically causes gastroenteritis and mesenteric lymphadenitis and can also spread extra-intestinally. Yersinia outer protein P (YopP) has been shown to induce cytotoxicity and suppress pro-inflammatory responses...
Furamidine enhances IL-23-mediated autophagic response through IL-23R-TYK2-STAT3-dependent regulation of intracellular Ca²⁺ level to facilitate mycobacterial clearance in human macrophages [0.03%]
伏拉啶通过IL-23R-TYK2-STAT3依赖性调节胞内Ca²⁺水平增强IL-23介导的自噬反应以促进人类巨噬细胞中分枝杆菌的清除
Salina Patel,Mousumi Das,Dev Kiran Nayak et al.
Salina Patel et al.
Mycobacterium tuberculosis (M. tb), the etiological agent of tuberculosis (TB), subverts host immune responses to establish persistent infection by influencing cytokine production. An effective and balanced cytokine response is crucial for ...
Microbiome therapeutic PMC101 inhibits the translocation of carbapenem-resistant Klebsiella while enhancing eubiosis in antibiotic-induced dysbiosis mice [0.03%]
一种新型微生物治疗制剂PMC101能够抑制碳青霉烯耐药肺炎克雷伯菌的定植并改善抗生素导致的肠道菌群失调
Hanieh Tajdozian,Hoonhee Seo,Sukyung Kim et al.
Hanieh Tajdozian et al.
Carbapenem-resistant Enterobacteriaceae (CRE), known for their extensive antibiotic resistance, pose a severe global medical threat. Therefore, developing novel therapeutics beyond conventional antibiotics is urgently needed, and the import...