Genomic scans for diversity and selection signatures in Indian Red Sindhi cattle [0.03%]
印度红辛迪牛的多样性和选择标志的基因组扫描
Sonali Sonejita Nayak,Manjit Panigrahi,Divya Rajawat et al.
Sonali Sonejita Nayak et al.
Red Sindhi cattle, a distinguished dairy breed from India, are famous for their resilience in tropical climates and exceptional milk yield. This study utilized double digest restriction site-associated DNA sequencing (ddRADseq) across 96 in...
Exploring the genetic footprints of high altitude adapted humans and livestock [0.03%]
探究高海拔适应人类和家畜的遗传印迹
Manish Tiwari,Gayatri Gujar,Siriluck Ponsuksili et al.
Manish Tiwari et al.
High-altitude environments such as the Himalayas, Andes, and Ethiopian regions pose extreme environmental challenges like hypobaric hypoxia, cold stress, and extreme UV radiation. This prompts both short-term physiological and long-term gen...
Impaired immune metabolism in COPD driven by dysfunction of CXCL16 + alveolar macrophages: multivariate causal evidence [0.03%]
支气管扩张中由CXCL16+肺巨噬细胞功能障碍驱动的免疫代谢紊乱：多变量因果证据
Xianqiang Zhou,Yixin Zhang,Jie Yang et al.
Xianqiang Zhou et al.
Chronic obstructive pulmonary disease (COPD) is a leading global cause of mortality, with alveolar macrophages (AMs) dysfunction implicated in pathogenesis, though key molecular drivers remain unclear. This study integrated multi-omics appr...
Exploring genome, transcriptome, and microbiome interactions related to feed efficiency and methane emissions in Bos indicus through multi-omics network analysis [0.03%]
通过多组学网络分析探索基因组、转录组和微生物组在瘤牛饲料效率和甲烷排放方面的相互作用关系
Tainã Figueiredo Cardoso,Jennifer Jessica Bruscadin,Juliana Afonso et al.
Tainã Figueiredo Cardoso et al.
The minor effects of many SNP interactions often determine complex traits. This interaction, known as epistasis, represents a non-additive genetic effect in which the influence of one variant depends on the presence of others. In this study...
Identification and functional analysis of Rattus norvegicus Mammary carcinoma susceptibility 1b (Mcs1b) nominated variants [0.03%]
大鼠乳癌易感基因1b位点(Mcs1b)的鉴定及功能分析
Jennifer Sanders,Theodore S Kalbfleisch,Sasha Le et al.
Jennifer Sanders et al.
Rattus norvegicus (a.k.a. laboratory rat or Brown Rat) Mammary carcinoma susceptibility 1b (Mcs1b) is a concordant ortholog of a female breast cancer risk allele at human 5q11.2. Previously, Mcs1b was delimited to a 1.8 Mb interval of RNO2 ...
Exploration of plasma genetic markers mediating lung cancer-induced cardiovascular disorders based on genome wide association studies [0.03%]
基于全基因组关联研究的肺癌诱导的心血管疾病血浆遗传标志物探索分析
Tongyu Wang,Xinge Miao,Yin Wang et al.
Tongyu Wang et al.
Lung cancer is strongly associated with increased cardiovascular disease (CVD) risk, yet the molecular mechanisms remain poorly understood. Batched two-sample Mendelian randomization (MR) analysis was performed to investigate cancer types a...
Genome-wide association analysis highlights genomic regions and genes potentially associated with anestrus in crossbred gilts [0.03%]
猪非妊娠状态的全基因组关联分析识别出可能相关的基因组区域和基因
Monike Willemin Quirino,Cleverson Hebbel,Adriana Mércia Guaratini Ibelli et al.
Monike Willemin Quirino et al.
Anestrus, an infertility condition that affects several animal' species, is characterized by failing to display estrus. In pig production, it leads to the culling of 5 to 15% of the replacement gilts, resulting in significant losses impairi...
Jesús Ruberte,Paul N Schofield,John P Sundberg et al.
Jesús Ruberte et al.
The mouse remains the principal animal model for investigating human diseases due, among other reasons, to its anatomical similarities to humans. Despite its widespread use, the assumption that mouse anatomy is a fully established field wit...
Inflammatory cytokines are associated with stroke and risk factors of cerebrovascular diseases: a Mendelian randomization study [0.03%]
炎症细胞因子与卒中及脑血管疾病危险因素的相关性：一项孟德尔随机化研究
Zidong Li,Yingxuan Guo,Shuai Zhu et al.
Zidong Li et al.
The relationship of inflammatory cytokines with the subtypes and prognosis of stroke is not fully understood. Mendelian randomization (MR) was used to evaluate the bidirectional relationship of inflammatory cytokines with stroke subtype (bo...
Genome-wide selective sweep analysis in high-altitude Changthangi goats reveals candidate genes for pashmina fiber production [0.03%]
高原羊羔腹水病基因组选择清除分析揭示了帕什米纳羊毛生产候选基因
Ram Parsad,Sonika Ahlawat,Mahanthi Vasu et al.
Ram Parsad et al.
Domestic goats (Capra hircus) are vital to global agriculture, with over one billion animals supporting smallholder farmers worldwide. Among goat breeds, the Changthangi goat, native to the trans-Himalayan region of Ladakh, produces pashmin...