Genome-wide detection of copy number variations in indigenous Red Sindhi cattle using ddRAD sequencing [0.03%]
利用ddRAD测序检测红信迪希牛全基因组拷贝数变异
Sonali Sonejita Nayak,Shikha Mittal,Surya Kant Verma et al.
Sonali Sonejita Nayak et al.
In livestock, copy number variations (CNVs) are important structural differences that affect phenotypic variety and adaptation. The genome-wide CNVs in 72 Red Sindhi cattle, an indigenous breed prized for its disease resistance and heat tol...
MiR-127 and miR-375 regulate the proliferation and differentiation of yak intramuscular adipocyte precursors through the toll-like receptor signaling pathway [0.03%]
miR-127和miR-375通过 Toll 样受体信号通路调控牦牛肌间前脂肪细胞的增殖与分化
Quyangangmao Su,Linsheng Gui,Zhenling Wu et al.
Quyangangmao Su et al.
The yak, a livestock breed native to Qinghai Province in China. However, the low intramuscular fat (IMF) content of yak meat negatively impacts its taste and flavor, reducing its relative economic value. The experiment was conducted by inhi...
Fine-scale recombination rates inferred using the canFam4 assembly are strongly correlated with previous maps of dog recombination [0.03%]
利用canFam4基因组组装计算得到的精细图重组率与之前绘制的狗重组图谱高度相关
Jeffrey M Kidd
Jeffrey M Kidd
Genetic maps are a key resource for the analysis of genetic variation. Prior maps in dogs were based on the canFam3.1 genome assembly, which contains thousands of sequence gaps that include functional elements. Although long-read technologi...
A quality framework for cryopreserved rodent disease models: INFRAFRONTIER quality principles in EMMA archiving and distribution [0.03%]
冷冻保存的啮齿动物疾病模型的质量框架：INFRAFRONTIER质量原则在EMMA存档和分配中的应用
Hilke Ehlich,Andrew Blease,Reva Biju et al.
Hilke Ehlich et al.
Ensuring the quality and reproducibility of biological resources is essential for advancing biomedical research and upholding animal welfare standards. The European Mouse Mutant Archive (EMMA), part of the INFRAFRONTIER research infrastruct...
Cross-tissue enrichment patterns reveal functional clustering in normal human tissues from GTEx [0.03%]
基于GTEx的组织富集模式揭示正常人体组织的功能聚类
Arunima P S,Rajesh Raju,Debodipta Das
Arunima P S
Tissue specialization in humans is driven by their characteristic gene expression programs, yet the pathway-level enrichment and functional clustering of normal tissues as a comparative analysis platform remain poorly visualized. We analyze...
Multi-omics reveals that genes linked to succinylation regulate the onset of epilepsy through metabolic reprogramming [0.03%]
多组学揭示与琥珀酰化相关的基因通过代谢重编程调节癫痫的发病
Jia Fu,Hui Zhang,Xiaolei Yu et al.
Jia Fu et al.
The relationship between succinylation modification and epilepsy is not yet well defined, and the potential mediation of metabolic imbalance in its regulatory pathways requires deeper investigation. This study combines Mendelian randomizati...
The use of genistein and ambroxol may be an effective approach in correcting cellular dysfunctions of mucopolysaccharidosis-plus syndrome [0.03%]
异黄酮和氨溴索可能是矫正黏多糖堆积病兼发综合征细胞功能异常的有效方法
Zuzanna Cyske,Estera Rintz,Lidia Gaffke et al.
Zuzanna Cyske et al.
Mucopolysaccharidosis-plus syndrome (MPS plus or MPSPS) is an ultrarare inherited metabolic disease, caused by mutations in the VPS33A gene. Like in different types of mucopolysaccharidosis (MPS), glycosaminoglycan (GAG) storage in cells of...
E2F2 inhibits hippocampal neurogenesis in poststroke depression rats via the miR-1290/CBR1 axis [0.03%]
E2F2通过miR-1290/CBR1轴抑制卒中抑郁大鼠海马神经发生
Xili Yang,Xinyan Zhao,Kaiwen Fu et al.
Xili Yang et al.
Poststroke depression (PSD) presents with persistent depressive symptoms and cognitive dysfunction. This study explored the regulatory mechanism of E2F2 in hippocampal neurogenesis in PSD. In a PSD rat model established by MCAO and CUMS, de...
Genomic insights into the recent evolution and biodiversity of Italian sheep breeds [0.03%]
意大利绵羊品种的近期进化和生物多样性的基因组见解
Arianna Bionda,Alessio Negro,Viviana Floridia et al.
Arianna Bionda et al.
Italy hosts a remarkable ovine biodiversity shaped by centuries of history, regional traditions, and environmental heterogeneity. This diversity sustains agricultural production as well as ecosystem services and cultural heritage. Yet, many...
Rewiring cancer epigenome: lncRNA as modulator of chromatin architecture and neoplastic transformation [0.03%]
癌症表观基因组的重新连接：长链非编码RNA作为染色质结构和肿瘤发生的调节因子
Santosh Kumar,Subhadip Kundu,Surender K Sharawat et al.
Santosh Kumar et al.
Epigenetic rewiring modulates gene expression by reshaping chromatin architecture without altering the underlying DNA sequence. The eukaryotic genome is intricately folded within a dynamic three-dimensional nuclear architecture, which is vi...