Genome-wide characterization of copy number variations in Nagami Mithun (Bos frontalis) using whole-genome resequencing [0.03%]
利用全基因组重测序对囊米牦牛（Bos frontalis）拷贝数变异进行全基因组特征刻画
Bendangkokba Kichu,Harshit Kumar,Rajkrishna Mondal et al.
Bendangkokba Kichu et al.
Copy number variations (CNVs) represent an important source of structural genomic variation contributing to genomic diversity in livestock species. The Nagami Mithun (Bos frontalis), a semi-domesticated bovid indigenous to the forested hill...
ZDHHC5 may regulate the function of NKT cells and the immune response in Meniere's disease [0.03%]
ZDHHC5可能通过调节NKT细胞功能影响美尼尔病免疫功能失调
Ruilong Li,Keguang Chen
Ruilong Li
Meniere's disease (MD) is a heterogeneous, rare inner ear disorder characterized by recurrent vertigo, fluctuating sensorineural hearing loss, tinnitus, and aural fullness. Its molecular mechanisms remain unclear due to significant clinical...
Multi-omics analysis of HLTF context-dependent regulation across TCGA cohorts revealed its potential as new biomarker in tumour [0.03%]
HLTF的调控依赖于TCGA队列中的基因组背景的多组学分析及其作为肿瘤生物标志物的潜力
Alessia Canevotti,Marija Tursunović,Wendalina Tigani et al.
Alessia Canevotti et al.
The SNF2-family Helicase-Like Transcription Factor (HLTF) has been implicated in tumorigenesis, with evidence suggesting both tumour-suppressive and oncogenic functions. To clarify the nature of this increasingly emerging double function, w...
The future objectives of the International Mouse Phenotyping Consortium (IMPC): functional evaluation of human disease-relevant cis-regulatory elements in the mouse genome [0.03%]
国际小鼠表型分析联盟（IMPC）的未来目标：利用小鼠基因组评估与人类疾病相关的顺式调控元件的功能
Naoki Kubo,Akiko Oguchi,Hiroshi Masuya et al.
Naoki Kubo et al.
The International Mouse Phenotyping Consortium (IMPC) has established a large-scale functional genomics resource by systematically generating and phenotyping knockout mouse lines, linking gene function to mammalian phenotypes. However, inte...
Draft nuclear and complete mitochondrial genome assemblies of the flare-horned markhor (Capra falconeri): genomic resources for conservation and phylogenetics [0.03%]
长角马喀拉猴(Capra falconeri)的核基因组草图和完整的线粒体基因组组装：保护和系谱分析的基因组资源
Javeria Wali,Muhammad Waqas,Azhar Hussain Shah et al.
Javeria Wali et al.
The flare-horned markhor (Capra falconeri), a near-threatened mountain ungulate endemic to the Western Himalayas, remains vulnerable to habitat fragmentation, human disturbance, and environmental change. Although localized conservation effo...
Hypoxia-induced mechanism of TNBC promoting tumour cell proliferation through exosomal miRNA [0.03%]
缺氧通过外泌体miRNA诱导三阴性乳腺癌细胞增殖的机制研究
Xiangxin Zheng,Peng Yang,Sai Zhou et al.
Xiangxin Zheng et al.
Triple-negative breast cancer (TNBC), characterized by the absence of ER, PR, and HER2 expression, is associated with aggressive clinical behavior and limited treatment options. Hypoxia in the tumor microenvironment (TME) may influence inte...
Persistent homology of blood gene co-expression networks reveals reduced cycle structure in autism spectrum disorder: a multi-cohort analysis [0.03%]
基于血液基因共表达网络的持久同调分析揭示自闭症光谱障碍中环状结构减少：多队列分析
Mehmet Ali Balcı,Ömer Akgüller
Mehmet Ali Balcı
Autism spectrum disorder (ASD) exhibits substantial molecular heterogeneity that challenges traditional gene-centric analyses. We applied persistent homology of the graph 1-skeleton to characterize co-expression cycle structure in mutual in...
Semi-supervised ensemble learning with interval type-2 fuzzy-rough sets for Parkinson's disease prediction from multi-omics [0.03%]
基于区间T2模糊-粗集的半监督集成学习的多组学帕金森病预测方法
Ambika Hazarika,Ansuman Kumar,Anindya Halder
Ambika Hazarika
Parkinson's disease (PD) is a disorder involving progressive degeneration of the nervous system. Its clinical signs typically become noticeable only after substantial impairment has occurred in the substantia nigra, a brain region involved ...
Deciphering genetic diversity and selection footprints in Rathi cattle through ddRAD-based genome-wide analysis [0.03%]
基于ddRAD的全基因组分析解读拉提牛遗传多样性和选择痕迹
Nishu Bharia,Anal Bose,Sonali Sonejita Nayak et al.
Nishu Bharia et al.
Rathi cattle, an indigenous Bos indicus breed of north-western India, represent a valuable genetic resource due to their adaptation to arid environments, heat tolerance and dairy potential. However, genomic information on this breed remains...
Identification of shared hub genes CTNNB1, TJP1, PTK2, and TP53 associated with endothelial proliferation in infantile hemangioma and glioblastoma [0.03%]
识别出与婴幼儿血管瘤和胶质母细胞瘤内皮增殖相关的共有中心基因CTNNB1、TJP1、PTK2 和TP53
Yanli Niu,Jing Li,Liang Wang et al.
Yanli Niu et al.
Infantile hemangioma (IH) and glioblastoma multiforme (GBM) are clinically distinct but share vascular and proliferative characteristics. This study aimed to identify common transcriptional and regulatory mechanisms between IH and GBM to un...