E2F2 inhibits hippocampal neurogenesis in poststroke depression rats via the miR-1290/CBR1 axis [0.03%]
E2F2通过miR-1290/CBR1轴抑制卒中抑郁大鼠海马神经发生
Xili Yang,Xinyan Zhao,Kaiwen Fu et al.
Xili Yang et al.
Poststroke depression (PSD) presents with persistent depressive symptoms and cognitive dysfunction. This study explored the regulatory mechanism of E2F2 in hippocampal neurogenesis in PSD. In a PSD rat model established by MCAO and CUMS, de...
Genomic insights into the recent evolution and biodiversity of Italian sheep breeds [0.03%]
意大利绵羊品种的近期进化和生物多样性的基因组见解
Arianna Bionda,Alessio Negro,Viviana Floridia et al.
Arianna Bionda et al.
Italy hosts a remarkable ovine biodiversity shaped by centuries of history, regional traditions, and environmental heterogeneity. This diversity sustains agricultural production as well as ecosystem services and cultural heritage. Yet, many...
Rewiring cancer epigenome: lncRNA as modulator of chromatin architecture and neoplastic transformation [0.03%]
癌症表观基因组的重新连接：长链非编码RNA作为染色质结构和肿瘤发生的调节因子
Santosh Kumar,Subhadip Kundu,Surender K Sharawat et al.
Santosh Kumar et al.
Epigenetic rewiring modulates gene expression by reshaping chromatin architecture without altering the underlying DNA sequence. The eukaryotic genome is intricately folded within a dynamic three-dimensional nuclear architecture, which is vi...
MoG+3.0: expanded structural variant visualization and integration of genomic data from five newly analyzed mouse strains [0.03%]
MoG+3.0：扩展的结构变异可视化以及来自五个新分析的小鼠品系的基因组数据整合
Toyoyuki Takada,Hideyuki Miyazawa,Masanobu Yamagata et al.
Toyoyuki Takada et al.
The MoG+ (Mouse Genome database with high added value), which has been operational since 2019, provides detailed visualization of genomic variations in mouse experimental strains, including wild-derived inbred strains, in particular those m...
AHDSN: an attention-enabled hybrid deep sequential network for cancer survivability prediction from multi-omics data [0.03%]
一种基于注意力机制的混合深度序列网络用于多组学数据驱动的癌症生存预测模型AHDSN
Ambika Hazarika,Ansuman Kumar,Anindya Halder
Ambika Hazarika
Cancer is the leading threat to human health and lifespan. Every day, the number of deaths caused by cancer continues to rise. Therefore, accurately predicting survivability from cancer has become an important area in cancer research. In pr...
Exploring the mediating role of potential therapeutic genes in the pathogenesis of hypopituitarism through the metabolites from a genomic perspective [0.03%]
从基因组学角度通过代谢物探讨潜在治疗基因在垂体功能减退症发病机制中的中介作用
Yesheng Sun,Ying Zhang,Tengfei Luan et al.
Yesheng Sun et al.
Hypopituitarism is a severe endocrine disorder characterized by a partial or complete hormone deficiency in the anterior or posterior pituitary gland. Current treatment relies on hormone replacement therapy, which is unable to mimic normal ...
Multi-omics dissection of RAD21-PON1 axis reveals metabolic-immune crosstalk and prognostic significance in hepatocellular carcinoma [0.03%]
RAD21-PON1轴的多组学分析揭示了肝细胞癌中的代谢免疫交叉对话及预后意义
Zhe Liu,Fang Liu,Zhongyu Yao et al.
Zhe Liu et al.
RAD21, a key cohesin subunit, participates in chromatin regulation and may influence tumor metabolism and immunity. Its role in liver HCC remains unclear. We investigated whether RAD21 regulates PON1 and how this axis integrates metabolic a...
Highly expressed TRIM32 promoted traumatic wound healing by mediating ubiquitination of PIAS1 [0.03%]
TRIM32通过介导PIAS1的泛素化促进创伤性伤口愈合
Jingwei Wang,Xiaojie Zhao
Jingwei Wang
Poor wound healing is a significant challenge that can result in lower limb amputation. Unfortunately, effective treatments are currently limited. Therefore, there is an urgent need to investigate new targets within the skin healing process...
MicroRNA dysregulation in male infertility: Insights into mechanisms, biomarkers, and therapeutic strategies- review [0.03%]
男性不孕症中微小核糖核酸的失调：机制、生物标志物及治疗策略综述
Manoharan Shunmuga Sundram,Sanjeeva Ready Nellapalli,Radha Vembu et al.
Manoharan Shunmuga Sundram et al.
Infertility affects ~ 15% of couples globally, with male factors contributing to ~ 50% of cases. Male infertility comes from a variety genetic, hormonal, environmental, and lifestyle factors. Yet, a large proportion of cases are idiopathic ...
Enhanced computational strategies for categorizing HER2 kinase domain variants of uncertain significance through structural and functional analysis [0.03%]
基于结构和功能分析的HER2激酶区变异意义未知位点计算策略研究进展
Tamizhini Loganathan,C George Priya Doss
Tamizhini Loganathan
The HER2 (human epidermal growth factor receptor 2) kinase domain plays a pivotal role in receptor-mediated signaling and is frequently mutated across various cancer types. Variants of uncertain significance (VUS) within this domain pose si...