Exploration of shared gene signatures and molecular mechanisms between psoriasis and COVID-19: evidence from transcriptome data [0.03%]
基于转录组数据探索银屑病和新冠肺炎共有的基因特征及分子机制
Rong-Jing Dong,Lu-Hui Yang,Yu-Ye Li et al.
Rong-Jing Dong et al.
Emerging evidence suggests that the onset or worsening of psoriasis can occur following COVID-19 infection or vaccination. Additionally, individuals with psoriasis may be more susceptible to COVID-19. However, the underlying mechanisms driv...
Genetic heritage of war: exploring transgenerational inheritance of PTSD and its molecular background [0.03%]
战争的遗传遗产：探讨PTSD的跨代传递及其分子背景
Nerma Džaferović,Adna Ašić
Nerma Džaferović
This review article summarizes the available data about the potential link between war-related trauma and post-traumatic stress disorder (PTSD) and epigenetic alterations that could manifest in future generations. DNA methylation variations...
MiR-324-5p mitigates experimental acute pancreatitis by suppressing Rock2 expression [0.03%]
miR-324-5p通过抑制Rock2表达缓解急性胰腺炎
Qian Chen,Zhao Shen,Qingmei Wang et al.
Qian Chen et al.
Acute pancreatitis (AP) is a lethal pancreatic disease with limited therapeutic options. MicroRNA-324-5p (miR-324-5p) has shown dual roles across diseases, but its specific role and molecular targets in AP remain unclear. Plasma miR-324-5p ...
Alantolactone curbs the malignant progression of bladder cancer partly via the HSP90AB1/LRP5/β-catenin axis [0.03%]
阿尔托醇通过HSP90AB1/LRP5/β-连环蛋白轴途径抑制膀胱癌的恶性进展
Lijun Zhi,Lin Yuan
Lijun Zhi
Bladder cancer (BCa) represents a global health problem. Traditional Chinese medicine has a long history of treating cancers. This study has been conducted to illustrate the anti-cancer effects of alantolactone (ALT) in BCa and to explore t...
Genomic structure and selection history across Angus populations worldwide: insights from ROH, selection mapping, and functional analyses [0.03%]
全球安格斯牛种的基因组结构与选择育种历史分析：基于ROH、选择图谱和功能分析的视角
Henrique A Mulim,Gabriel S Campos,Fernando F Cardoso et al.
Henrique A Mulim et al.
Angus cattle, originally from Scotland, have been selectively bred for over 400 years, making them one of the most prominent beef breeds globally. Known for their adaptability, natural polled traits, and high-quality beef, Angus cattle have...
Rare and common variants in ERAP1 and ERAP2 selected for in response to Yersinia pestis infection contribute to autoimmune disease including inflammatory bowel disease [0.03%]
罕见和常见的ERAP1和ERAP2变异体对鼠疫耶尔森氏菌感染的免疫反应导致自身免疫疾病包括炎症性肠病
Lynn K Win,Guo Cheng,James J Ashton et al.
Lynn K Win et al.
Endoplasmic reticulum aminopeptidases (ERAP) facilitate antigen presentation. Variation in ERAP1 and ERAP2 genes underwent selection during the Black Death and impact autoimmune disease susceptibility. We assess the burden of functionally i...
Long-read whole-genome sequencing of SHR rat substrains with distinct substance use phenotypes [0.03%]
具有不同物质使用表型的SHR大鼠亚系的长读全长基因组测序
Adil Abdurahaman,Paige M Lemen,Kathleen M Kantak et al.
Adil Abdurahaman et al.
The Spontaneously Hypertensive Rat (SHR) is a widely used model for hypertension and, more recently, for neuropsychiatric disorders such as ADHD and Substance Use Disorder (SUD). Despite a common origin, SHR substrains from different vendor...
Genome-wide SNP evidence for the genetic uniqueness of indigenous cattle population [0.03%]
全基因组SNP证据揭示地方牛品种的独特性
Kiyevi G Chishi,Sanjeev Singh,Rangasai Chandra Goli et al.
Kiyevi G Chishi et al.
Dynamics and regulatory role of 5-methylcytosine modification in mRNA colocalized with RNA G-quadruplex structure in mouse development [0.03%]
小鼠发育过程中与RNA G-四链体结构共定位的mRNA上5-甲基胞嘧啶修饰的动力学及调控作用
Madhumitha S,Sujeet Kumar Satapathy,Srinivasan Muthuswamy et al.
Madhumitha S et al.
Post-transcriptional regulation is a pivotal event in controlling gene expression, modulated by various epitranscriptomic modifications and RNA secondary structures, including G-quadruplexes (G4s). Recent studies have shown the co-occurrenc...
ZDHHC5 and ZDHHC14 promote depression via the mediation of double-negative T cells [0.03%]
ZDHHC5和ZDHHC14通过调节双重阴性T细胞促进抑郁作用
Gengchen Lu,Yining Zhou,Lingwei Song et al.
Gengchen Lu et al.
This study aims to identify palmitoylation modification-related genes involved in depression and to explore the mechanism of gene action through the mediation of immune cells. We analyzed the latest reviews on palmitoylation, integrated pal...