m5c-modified LINC01094 participates in epithelial-mesenchymal transition and metastasis of cervical cancer cells via the ZNF582-SIRT1/p53 axis [0.03%]
M5C修饰的LINC01094通过ZNF582-SIRT1/p53轴参与宫颈癌细胞上皮间质转化及转移
Xia Lu,Lili Yao,Xu Xu et al.
Xia Lu et al.
Cervical cancer (CC) remains a significant global health burden despite advances in prevention and screening. Emerging evidence highlights the critical role of long non-coding RNAs (lncRNAs) and RNA modifications in tumorigenesis. Here, we ...
Complement in brain and eye disease: shared mechanisms, convergent pathologies, and common therapeutic opportunities [0.03%]
补体在脑和眼疾病中的作用：共有的机制、趋同的病理改变及潜在的治疗方法
Nikoleta Daskoulidou,Jacqui Nimmo,Matthew Bright et al.
Nikoleta Daskoulidou et al.
The brain and eye share striking anatomical, physiological, and immunological similarities. Both are protected by specialised vascular barriers, the blood-brain barrier (BBB) and blood-retinal barrier (BRB) respectively, that maintain homeo...
Genome-wide in-silico identification and characterization of LTR retrotransposons in domestic goat (Capra hircus) [0.03%]
家养山羊(Capra hircus)LTR逆转座子的全基因组in-silico鉴定及特征分析
Beenish Ishtiaq,Fiaz Khan,Faisal Nouroz et al.
Beenish Ishtiaq et al.
Candidate genes related to growth and milk production in three Anatolian goats revealed by GWAS [0.03%]
基于GWAS揭示的三种安纳托利亚山羊生长及产奶相关候选基因
Eymen Demir,Umit Bilginer,Huriye Doğru et al.
Eymen Demir et al.
This study aimed to identify candidate genes related to birth weight (BW), live weight at 90th day (90-LW), and lactation milk yield (LMY) in Hair (HAI), Honamlı (HNM), and Kabakulak (KBK) goats, providing a genome-wide basis for further s...
Detection of selection signatures in indigenous African cattle reveals genomic footprints of adaptation, production and temperament traits [0.03%]
非洲土种牛的选择信号检测揭示了适应性、生产和性情特征的基因组印记
Rodney Okwasiimire,Donald R Kugonza,Junxin Gao et al.
Rodney Okwasiimire et al.
Indigenous cattle account for approximately 80% of Uganda's cattle population. These animals are well adapted to the country's ten agroecological zones and are mainly kept under pastoral and agropastoral systems. Unlike commercial breeds, t...
Genomic architecture of insertion-deletion (indel) variants in beetal goats of India [0.03%]
印度贝特尔山羊插入缺失变异的基因组结构
J Saalom King,Marykutty Thomas,Jinty Sukumaran et al.
J Saalom King et al.
Beetal goats, the second largest indigenous goat breed in India, are known for their superior growth and production traits. In this study, we performed a comprehensive genome-wide characterization of insertion-deletion (indel) variants in t...
Zachary Tatom,Michael F Miles,Abraham A Palmer
Zachary Tatom
Mouse models have played a critical role in complementing human genetics research due to their genetic similarity to humans and well-annotated and tractable genome. For over 15 years, the Diversity Outbred (DO) mice have existed as a powerf...
Exploring the molecular function of LYPD3 from pan-cancer to lung cancer: based on bioinformatics and cellular experiments [0.03%]
基于生物信息学和细胞实验探究LYPD3的分子功能：从泛癌到肺癌视角
Yuan-Xiang Shi,Jian-Hua Yan,Peng-Hui Dai
Yuan-Xiang Shi
Multi-omics Mendelian randomization and machine learning identify candidate therapeutic targets for Alzheimer's and Parkinson's diseases [0.03%]
整合组学孟德尔随机化和机器学习识别出了老年性和帕金森病潜在的治疗靶点
Xun Li,Lei Zhang,Jinyan Xia et al.
Xun Li et al.
Neurodegenerative diseases (NDDs), including Alzheimer's disease (AD) and Parkinson's disease (PD), are major public health challenges lacking effective therapies. To identify potential drug targets, we integrated large-scale genome-wide as...
Identification and validation of PANX1 as an inflammasome-related biomarker in gestational diabetes mellitus: insights from machine learning and experimental approaches [0.03%]
基于机器学习和实验方法鉴定并验证PANX1作为妊娠期糖尿病相关炎症小体生物标志物的意义
Padmanaban M Abirami,K L Milan,M Anuradha et al.
Padmanaban M Abirami et al.
Gestational diabetes mellitus (GDM) is characterized by glucose intolerance during pregnancy, resulting from insulin resistance, and is associated with increased maternal and neonatal risks. Inflammasomes play a critical role in GDM pathoph...