Genome-wide SNP evidence for the genetic uniqueness of indigenous cattle population [0.03%]
全基因组SNP证据揭示地方牛品种的独特性
Kiyevi G Chishi,Sanjeev Singh,Rangasai Chandra Goli et al.
Kiyevi G Chishi et al.
Dynamics and regulatory role of 5-methylcytosine modification in mRNA colocalized with RNA G-quadruplex structure in mouse development [0.03%]
小鼠发育过程中与RNA G-四链体结构共定位的mRNA上5-甲基胞嘧啶修饰的动力学及调控作用
Madhumitha S,Sujeet Kumar Satapathy,Srinivasan Muthuswamy et al.
Madhumitha S et al.
Post-transcriptional regulation is a pivotal event in controlling gene expression, modulated by various epitranscriptomic modifications and RNA secondary structures, including G-quadruplexes (G4s). Recent studies have shown the co-occurrenc...
ZDHHC5 and ZDHHC14 promote depression via the mediation of double-negative T cells [0.03%]
ZDHHC5和ZDHHC14通过调节双重阴性T细胞促进抑郁作用
Gengchen Lu,Yining Zhou,Lingwei Song et al.
Gengchen Lu et al.
This study aims to identify palmitoylation modification-related genes involved in depression and to explore the mechanism of gene action through the mediation of immune cells. We analyzed the latest reviews on palmitoylation, integrated pal...
Genome-wide detection of copy number variations in indigenous Red Sindhi cattle using ddRAD sequencing [0.03%]
利用ddRAD测序检测红信迪希牛全基因组拷贝数变异
Sonali Sonejita Nayak,Shikha Mittal,Surya Kant Verma et al.
Sonali Sonejita Nayak et al.
In livestock, copy number variations (CNVs) are important structural differences that affect phenotypic variety and adaptation. The genome-wide CNVs in 72 Red Sindhi cattle, an indigenous breed prized for its disease resistance and heat tol...
MiR-127 and miR-375 regulate the proliferation and differentiation of yak intramuscular adipocyte precursors through the toll-like receptor signaling pathway [0.03%]
miR-127和miR-375通过 Toll 样受体信号通路调控牦牛肌间前脂肪细胞的增殖与分化
Quyangangmao Su,Linsheng Gui,Zhenling Wu et al.
Quyangangmao Su et al.
The yak, a livestock breed native to Qinghai Province in China. However, the low intramuscular fat (IMF) content of yak meat negatively impacts its taste and flavor, reducing its relative economic value. The experiment was conducted by inhi...
Fine-scale recombination rates inferred using the canFam4 assembly are strongly correlated with previous maps of dog recombination [0.03%]
利用canFam4基因组组装计算得到的精细图重组率与之前绘制的狗重组图谱高度相关
Jeffrey M Kidd
Jeffrey M Kidd
Genetic maps are a key resource for the analysis of genetic variation. Prior maps in dogs were based on the canFam3.1 genome assembly, which contains thousands of sequence gaps that include functional elements. Although long-read technologi...
A quality framework for cryopreserved rodent disease models: INFRAFRONTIER quality principles in EMMA archiving and distribution [0.03%]
冷冻保存的啮齿动物疾病模型的质量框架：INFRAFRONTIER质量原则在EMMA存档和分配中的应用
Hilke Ehlich,Andrew Blease,Reva Biju et al.
Hilke Ehlich et al.
Ensuring the quality and reproducibility of biological resources is essential for advancing biomedical research and upholding animal welfare standards. The European Mouse Mutant Archive (EMMA), part of the INFRAFRONTIER research infrastruct...
Cross-tissue enrichment patterns reveal functional clustering in normal human tissues from GTEx [0.03%]
基于GTEx的组织富集模式揭示正常人体组织的功能聚类
Arunima P S,Rajesh Raju,Debodipta Das
Arunima P S
Tissue specialization in humans is driven by their characteristic gene expression programs, yet the pathway-level enrichment and functional clustering of normal tissues as a comparative analysis platform remain poorly visualized. We analyze...
Multi-omics reveals that genes linked to succinylation regulate the onset of epilepsy through metabolic reprogramming [0.03%]
多组学揭示与琥珀酰化相关的基因通过代谢重编程调节癫痫的发病
Jia Fu,Hui Zhang,Xiaolei Yu et al.
Jia Fu et al.
The relationship between succinylation modification and epilepsy is not yet well defined, and the potential mediation of metabolic imbalance in its regulatory pathways requires deeper investigation. This study combines Mendelian randomizati...
The use of genistein and ambroxol may be an effective approach in correcting cellular dysfunctions of mucopolysaccharidosis-plus syndrome [0.03%]
异黄酮和氨溴索可能是矫正黏多糖堆积病兼发综合征细胞功能异常的有效方法
Zuzanna Cyske,Estera Rintz,Lidia Gaffke et al.
Zuzanna Cyske et al.
Mucopolysaccharidosis-plus syndrome (MPS plus or MPSPS) is an ultrarare inherited metabolic disease, caused by mutations in the VPS33A gene. Like in different types of mucopolysaccharidosis (MPS), glycosaminoglycan (GAG) storage in cells of...