Vascular contribution to cognitive impairment and dementia (VCID): proceedings of 2025 workshop of the Jackson Laboratory [0.03%]
血管源性认知障碍和痴呆(VCID)：杰克逊实验室2025年研讨会报告
Mehwish Anwer,Tetiana Poliakova,Ricardo D&#x;Oliveira Albanus et al.
Mehwish Anwer et al.
The first Vascular Contributions to Cognitive Impairment and Dementia (VCID) Workshop, held on May12-16, 2025 at The Jackson Laboratory, provided scientific content and career development training in the latest developments in VCID and Alzh...
The North African maternal genetic diversity enriched by historical migrations: insights from a comprehensive analysis of complete mitogenomes [0.03%]
北非母系遗传多样性由历史迁徙丰富化：来自完整线粒体基因组全面分析的启示
Nasma Boumajdi,Houda Bendani,Lahcen Belyamani et al.
Nasma Boumajdi et al.
North Africa has experienced significant gene flow throughout history, with Morocco occupying a strategic location at the crossroads of Africa and Europe. In this study, we compiled 869 complete mitogenome sequences from six North African p...
Regulation of humeral fracture healing by miR-21 through SMAD7-mediated activation of Wnt/β-catenin signaling [0.03%]
miR-21通过SMAD7介导的Wnt/β-catenin信号激活调节肱骨骨折愈合
Juan Liu,Hong Ren,Shuo Zhang et al.
Juan Liu et al.
MicroRNAs (miRNAs) are key regulators of bone regeneration. We investigated the role of miR-21 in humeral fracture (HF) healing, focusing on its interaction with the SMAD7/Wnt/β-catenin signaling axis. Serum and tissue levels of miR-21 wer...
Knockdown of SOX4 attenuates sepsis myocardial injury by inhibiting the EZH2/H3K27me3/SOCS3 axis [0.03%]
SOX4敲低通过抑制EZH2/H3K27me3/SOCS3轴缓解脓毒症心肌损伤
Hongyan Zhao,Weirong Tao,Rong Huang et al.
Hongyan Zhao et al.
Inhibition of SOX4 has been reported to ameliorate myocardial ischemic injury, yet its role in sepsis myocardial injury remains unknown. To explore the protective effects and mechanisms of SOX4 inhibition in septic myocardial injury. AC16 c...
Genome assembly of the Neotropical marsh rat Holochilus nanus (Cricetidae: Sigmodontinae) brings insights on B and sex chromosome evolution [0.03%]
南美洲热带沼泽鼠Holochilus nanus（鼠科Sigmodontinae）基因组的组装为B性和性染色体进化提供了见解
Camila Nascimento Moreira,Jordana Oliveira,Yatiyo Yonenaga-Yassuda et al.
Camila Nascimento Moreira et al.
The Neotropical region comprises approximately 27% of mammal diversity, and rodents of the tribe Oryzomyini represent a significant portion of that. This diversity is reflected in the karyotype variability of the tribe, with a huge number o...
Integrated multi-omics and machine learning prioritize key immune genes for multiple sclerosis risk prediction [0.03%]
整合多组学和机器学习优先考虑多发性硬化症风险预测的关键免疫基因
Ming Chen,Duran Zhao,Haiping Fan et al.
Ming Chen et al.
LAPTM5 potentiates airway remodeling by regulating MAPKs-mediated airway smooth muscle cells' dysfunction [0.03%]
LAPTM5通过调节MAPKs介导的气道平滑肌细胞功能障碍促进气道重塑
Lijiao Jiang,Yaping Ying,Haihong Jin et al.
Lijiao Jiang et al.
Airway remodeling is one of the hallmarks of asthma in which the dysregulation of airway smooth muscle cells (ASMCs) plays a part. However, the role of LAPTM5 in asthma is largely yet to be elucidated. In this study, the expression of LAPTM...
Hypoxia-induced circ_0017521 enhances glycolysis and promotes NSCLC progression via upregulating the PFKFB3/PI3K-AKT pathway [0.03%]
缺氧诱导的circ_0017521通过上调PFKFB3/PI3K-AKT途径增强糖酵解并促进NSCLC进展
Jian Zhu,Jin Yan,Yuanyuan Zhang et al.
Jian Zhu et al.
The hypoxic microenvironment is a critical feature of malignant progression in non-small cell lung cancer (NSCLC). However, the regulatory role of circular RNAs (circRNAs) in this context remains incompletely understood. Hypoxia-related cir...
Large-scale mouse mutagenesis identifies novel genes affecting vertebral anatomy [0.03%]
大规模的小鼠诱变鉴定了影响椎骨解剖的新基因
Ximena Ibarra-Soria,Elizabeth Webb,John F Mulley
Ximena Ibarra-Soria
We analyzed the International Mouse Phenotyping Consortium (IMPC) release 19 set of 8,539 phenotyped whole-gene knockouts to identify 204 genes that alter vertebral anatomy and development. These genes are broadly grouped into six categorie...
Genome-wide association study identifies significant SNPs for milk production and stature traits in Karan Fries cattle [0.03%]
卡兰弗里斯奶牛产奶性状和体尺性状的全基因组关联分析
Pritam Pal,Ishmeet Kumar,Manisha Choudhary et al.
Pritam Pal et al.