Exploring the molecular function of LYPD3 from pan-cancer to lung cancer: based on bioinformatics and cellular experiments [0.03%]
基于生物信息学和细胞实验探究LYPD3的分子功能：从泛癌到肺癌视角
Yuan-Xiang Shi,Jian-Hua Yan,Peng-Hui Dai
Yuan-Xiang Shi
Multi-omics Mendelian randomization and machine learning identify candidate therapeutic targets for Alzheimer's and Parkinson's diseases [0.03%]
整合组学孟德尔随机化和机器学习识别出了老年性和帕金森病潜在的治疗靶点
Xun Li,Lei Zhang,Jinyan Xia et al.
Xun Li et al.
Neurodegenerative diseases (NDDs), including Alzheimer's disease (AD) and Parkinson's disease (PD), are major public health challenges lacking effective therapies. To identify potential drug targets, we integrated large-scale genome-wide as...
Identification and validation of PANX1 as an inflammasome-related biomarker in gestational diabetes mellitus: insights from machine learning and experimental approaches [0.03%]
基于机器学习和实验方法鉴定并验证PANX1作为妊娠期糖尿病相关炎症小体生物标志物的意义
Padmanaban M Abirami,K L Milan,M Anuradha et al.
Padmanaban M Abirami et al.
Gestational diabetes mellitus (GDM) is characterized by glucose intolerance during pregnancy, resulting from insulin resistance, and is associated with increased maternal and neonatal risks. Inflammasomes play a critical role in GDM pathoph...
Exploration of shared gene signatures and molecular mechanisms between psoriasis and COVID-19: evidence from transcriptome data [0.03%]
基于转录组数据探索银屑病和新冠肺炎共有的基因特征及分子机制
Rong-Jing Dong,Lu-Hui Yang,Yu-Ye Li et al.
Rong-Jing Dong et al.
Emerging evidence suggests that the onset or worsening of psoriasis can occur following COVID-19 infection or vaccination. Additionally, individuals with psoriasis may be more susceptible to COVID-19. However, the underlying mechanisms driv...
Genetic heritage of war: exploring transgenerational inheritance of PTSD and its molecular background [0.03%]
战争的遗传遗产：探讨PTSD的跨代传递及其分子背景
Nerma Džaferović,Adna Ašić
Nerma Džaferović
This review article summarizes the available data about the potential link between war-related trauma and post-traumatic stress disorder (PTSD) and epigenetic alterations that could manifest in future generations. DNA methylation variations...
MiR-324-5p mitigates experimental acute pancreatitis by suppressing Rock2 expression [0.03%]
miR-324-5p通过抑制Rock2表达缓解急性胰腺炎
Qian Chen,Zhao Shen,Qingmei Wang et al.
Qian Chen et al.
Acute pancreatitis (AP) is a lethal pancreatic disease with limited therapeutic options. MicroRNA-324-5p (miR-324-5p) has shown dual roles across diseases, but its specific role and molecular targets in AP remain unclear. Plasma miR-324-5p ...
Alantolactone curbs the malignant progression of bladder cancer partly via the HSP90AB1/LRP5/β-catenin axis [0.03%]
阿尔托醇通过HSP90AB1/LRP5/β-连环蛋白轴途径抑制膀胱癌的恶性进展
Lijun Zhi,Lin Yuan
Lijun Zhi
Bladder cancer (BCa) represents a global health problem. Traditional Chinese medicine has a long history of treating cancers. This study has been conducted to illustrate the anti-cancer effects of alantolactone (ALT) in BCa and to explore t...
Genomic structure and selection history across Angus populations worldwide: insights from ROH, selection mapping, and functional analyses [0.03%]
全球安格斯牛种的基因组结构与选择育种历史分析：基于ROH、选择图谱和功能分析的视角
Henrique A Mulim,Gabriel S Campos,Fernando F Cardoso et al.
Henrique A Mulim et al.
Angus cattle, originally from Scotland, have been selectively bred for over 400 years, making them one of the most prominent beef breeds globally. Known for their adaptability, natural polled traits, and high-quality beef, Angus cattle have...
Rare and common variants in ERAP1 and ERAP2 selected for in response to Yersinia pestis infection contribute to autoimmune disease including inflammatory bowel disease [0.03%]
罕见和常见的ERAP1和ERAP2变异体对鼠疫耶尔森氏菌感染的免疫反应导致自身免疫疾病包括炎症性肠病
Lynn K Win,Guo Cheng,James J Ashton et al.
Lynn K Win et al.
Endoplasmic reticulum aminopeptidases (ERAP) facilitate antigen presentation. Variation in ERAP1 and ERAP2 genes underwent selection during the Black Death and impact autoimmune disease susceptibility. We assess the burden of functionally i...
Long-read whole-genome sequencing of SHR rat substrains with distinct substance use phenotypes [0.03%]
具有不同物质使用表型的SHR大鼠亚系的长读全长基因组测序
Adil Abdurahaman,Paige M Lemen,Kathleen M Kantak et al.
Adil Abdurahaman et al.
The Spontaneously Hypertensive Rat (SHR) is a widely used model for hypertension and, more recently, for neuropsychiatric disorders such as ADHD and Substance Use Disorder (SUD). Despite a common origin, SHR substrains from different vendor...