Primary biliary cirrhosis and rheumatoid arthritis: a comprehensive study combining genetics and transcriptomics [0.03%]
原发性胆汁性肝硬化和类风湿关节炎：结合遗传学和转录组学的综合研究
Mingyi Yang,Honghao Ren,Xiaodong Ren et al.
Mingyi Yang et al.
Observational investigations have discerned a correlation between primary biliary cirrhosis (PBC) and rheumatoid arthritis (RA). The primary objective of this study is to elucidate the disease risk correlation between them in terms of genet...
Genome-wide characterization of HSP70 and HSP90 subfamilies in Yak (Bos grunniens): expression patterns under cold and chemical hypoxia conditions [0.03%]
牦牛(HIS70和HSP90亚家族的全基因组特征鉴定：在寒冷及化学缺氧条件下的表达模式
Yufei Zan,Caiwei Ma,Ziqiang Ding et al.
Yufei Zan et al.
Assessment of genome-wide genetic variability and population divergence of four native Turkish sheep breeds [0.03%]
四种土库曼本地绵羊品种的全基因组遗传变异和种群分化评估
Bahar Argun Karslı,Eymen Demir,Umit Bilginer et al.
Bahar Argun Karslı et al.
Genetic variability is crucial for enhancing economically important traits and for developing effective conservation strategies in livestock populations. In this study, genome-wide genetic variability and population divergence were evaluate...
Integrative immunogenomic and experimental characterization reveals CXCL9, CXCL13, CCL5 and CD74 as key oncogenic drivers in breast cancer [0.03%]
整合的免疫基因组和实验分析揭示了CXCL9、CXCL13、CCL5和CD74是乳腺癌中的关键致癌驱动因素
Mohammed A Alshehri,Mohammed Alissa
Mohammed A Alshehri
Breast cancer remains the most prevalent malignancy among women worldwide, driven by complex interactions between tumor-intrinsic factors and the immune microenvironment. Understanding immune-related molecular regulators is essential to imp...
Tissue-specific transcriptional epistasis between Prkn and Lrrk2 during mycobacterial infection [0.03%]
帕金森病相关基因Prkn和Lrrk2在结核分枝杆菌感染下的组织特异性转录上位性作用机制研究
Monica Dallmann-Sauer,Yong Zhong Xu,Wilian Correa-Macedo et al.
Monica Dallmann-Sauer et al.
Unravelling male infertility through epigenetics: present understanding and future challenges [0.03%]
从表观遗传学视角解读男性不育：现状与挑战
S Amrita Malini,Almitra Abhijit Dravid,Ritwika Saha et al.
S Amrita Malini et al.
Hongwu mixture exerts inhibition on triple-negative breast cancer by regulating SAV1/Hippo signaling through ZNF143 [0.03%]
通过ZNF143调节SAV1/Hippo信号对三阴性乳腺癌的洪朴药方混合物作用研究
Aiping Wu,Jun Ma,Qiong Wang et al.
Aiping Wu et al.
Hongwu mixture (HWM) consists of Taxus chinensis, Marsdenia tenacissima, Rhizoma Curcumae, and Semen coicis. The objective of this study was to ascertain the potential role of the Hongwu mixture (HWM) in the treatment of triple-negative bre...
Comprehensive bioinformatics analysis and experimental validation reveal the role of circadian rhythm-related genes in the crosstalk between osteoporosis and atherosclerosis [0.03%]
昼夜节律相关基因在骨质疏松和动脉粥样硬化交互作用中的生物信息学分析及实验验证
Tengyan Liu,Jiashuang Fan,Jianyun Fang et al.
Tengyan Liu et al.
Osteoporosis (OP) and atherosclerosis (AS) are increasingly prevalent in aging populations and frequently coexist, sharing pathological features such as abnormal vascular calcification. However, the common marker genes underlying the crosst...
Polymorphisms in IRF3 exon 1 influence the immune response to Brucella infection in small ruminants [0.03%]
IRF3外显子1多态性影响小反刍动物布氏菌感染免疫应答
U A Rossi,M E Caffaro,D N Gaute et al.
U A Rossi et al.
Cancer-associated TRF1 mutations alter PARP1 interaction dynamics: an in silico study [0.03%]
癌症相关的TRF1突变通过计算机模拟改变了与PARP1相互作用的动力学
Apurwa Mishra,Trupti N Patel
Apurwa Mishra