Hypoxia-induced circ_0017521 enhances glycolysis and promotes NSCLC progression via upregulating the PFKFB3/PI3K-AKT pathway [0.03%]
缺氧诱导的circ_0017521通过上调PFKFB3/PI3K-AKT途径增强糖酵解并促进NSCLC进展
Jian Zhu,Jin Yan,Yuanyuan Zhang et al.
Jian Zhu et al.
The hypoxic microenvironment is a critical feature of malignant progression in non-small cell lung cancer (NSCLC). However, the regulatory role of circular RNAs (circRNAs) in this context remains incompletely understood. Hypoxia-related cir...
Large-scale mouse mutagenesis identifies novel genes affecting vertebral anatomy [0.03%]
大规模的小鼠诱变鉴定了影响椎骨解剖的新基因
Ximena Ibarra-Soria,Elizabeth Webb,John F Mulley
Ximena Ibarra-Soria
We analyzed the International Mouse Phenotyping Consortium (IMPC) release 19 set of 8,539 phenotyped whole-gene knockouts to identify 204 genes that alter vertebral anatomy and development. These genes are broadly grouped into six categorie...
Genome-wide association study identifies significant SNPs for milk production and stature traits in Karan Fries cattle [0.03%]
卡兰弗里斯奶牛产奶性状和体尺性状的全基因组关联分析
Pritam Pal,Ishmeet Kumar,Manisha Choudhary et al.
Pritam Pal et al.
m5c-modified LINC01094 participates in epithelial-mesenchymal transition and metastasis of cervical cancer cells via the ZNF582-SIRT1/p53 axis [0.03%]
M5C修饰的LINC01094通过ZNF582-SIRT1/p53轴参与宫颈癌细胞上皮间质转化及转移
Xia Lu,Lili Yao,Xu Xu et al.
Xia Lu et al.
Cervical cancer (CC) remains a significant global health burden despite advances in prevention and screening. Emerging evidence highlights the critical role of long non-coding RNAs (lncRNAs) and RNA modifications in tumorigenesis. Here, we ...
Complement in brain and eye disease: shared mechanisms, convergent pathologies, and common therapeutic opportunities [0.03%]
补体在脑和眼疾病中的作用：共有的机制、趋同的病理改变及潜在的治疗方法
Nikoleta Daskoulidou,Jacqui Nimmo,Matthew Bright et al.
Nikoleta Daskoulidou et al.
The brain and eye share striking anatomical, physiological, and immunological similarities. Both are protected by specialised vascular barriers, the blood-brain barrier (BBB) and blood-retinal barrier (BRB) respectively, that maintain homeo...
Genome-wide in-silico identification and characterization of LTR retrotransposons in domestic goat (Capra hircus) [0.03%]
家养山羊(Capra hircus)LTR逆转座子的全基因组in-silico鉴定及特征分析
Beenish Ishtiaq,Fiaz Khan,Faisal Nouroz et al.
Beenish Ishtiaq et al.
Candidate genes related to growth and milk production in three Anatolian goats revealed by GWAS [0.03%]
基于GWAS揭示的三种安纳托利亚山羊生长及产奶相关候选基因
Eymen Demir,Umit Bilginer,Huriye Doğru et al.
Eymen Demir et al.
This study aimed to identify candidate genes related to birth weight (BW), live weight at 90th day (90-LW), and lactation milk yield (LMY) in Hair (HAI), Honamlı (HNM), and Kabakulak (KBK) goats, providing a genome-wide basis for further s...
Detection of selection signatures in indigenous African cattle reveals genomic footprints of adaptation, production and temperament traits [0.03%]
非洲土种牛的选择信号检测揭示了适应性、生产和性情特征的基因组印记
Rodney Okwasiimire,Donald R Kugonza,Junxin Gao et al.
Rodney Okwasiimire et al.
Indigenous cattle account for approximately 80% of Uganda's cattle population. These animals are well adapted to the country's ten agroecological zones and are mainly kept under pastoral and agropastoral systems. Unlike commercial breeds, t...
Genomic architecture of insertion-deletion (indel) variants in beetal goats of India [0.03%]
印度贝特尔山羊插入缺失变异的基因组结构
J Saalom King,Marykutty Thomas,Jinty Sukumaran et al.
J Saalom King et al.
Beetal goats, the second largest indigenous goat breed in India, are known for their superior growth and production traits. In this study, we performed a comprehensive genome-wide characterization of insertion-deletion (indel) variants in t...
Zachary Tatom,Michael F Miles,Abraham A Palmer
Zachary Tatom
Mouse models have played a critical role in complementing human genetics research due to their genetic similarity to humans and well-annotated and tractable genome. For over 15 years, the Diversity Outbred (DO) mice have existed as a powerf...