Neurodevelopment as a shared genetic etiology linking sleep-related phenotypes and psychiatric disorders: a genome-wide pleiotropic analysis [0.03%]
神经发育作为连接睡眠相关表型和精神障碍的共同遗传病因：全基因组多效性分析
Yanmei Lin,Weimin Li,Xiaoxue Yang et al.
Yanmei Lin et al.
FES eQTL suppresses the progression of primary aldosteronism by regulating CD3 on TD CD8br immune cells: Mendelian randomization and mediation analysis [0.03%]
FES eQTL通过调节TD CD8+免疫细胞上的CD3抑制原发性醛固酮增多症的进展：孟德尔随机化和中介分析
Cai Deng,Huasheng Liao,Yizhao Wu et al.
Cai Deng et al.
The pathogenesis of primary aldosteronism (PA) remains incompletely understood. Current pharmacological therapies have significant limitations, thus highlighting the importance of recognizing new therapeutic targets for the diagnosis and tr...
CPNE1 modulates Parkinson's disease risk through peripheral immune cell function: a cross-tissue and single-cell causal inference study [0.03%]
CPNE1通过调节外周免疫细胞功能调控帕金森病发病风险：横跨多组织及单细胞的因果推断研究
Jing Zhao,Jia Fu,Jingjing Zhang et al.
Jing Zhao et al.
Impact of scale parameter for marker variance prior in some Bayesian whole-genome regression methods [0.03%]
标记方差先验尺度参数对某些Bayesian全基因组回归方法的影响
Özge Kozakli,Ayhan Ceyhan
Özge Kozakli
Oncogenic role of LncRNA DLEU2 in thyroid cancer through a NAT10/USP39 regulatory axis [0.03%]
长链非编码RNA DLEU2通过NAT10/USP39调控轴在甲状腺癌中的致癌作用
Jiwen Yang,Cheng Li,Weili Yin et al.
Jiwen Yang et al.
Genomic-microbial coevolution in human development: chromosome 2 fusion, and human accelerated regions [0.03%]
人类发育中的基因组-微生物共进化：第2号染色体融合和人类加速区域
Siddharth Singh,Md Shahadab,Kumar Sachin et al.
Siddharth Singh et al.
Cell-type-specific causal effects of CEBPD in CD8 + S100B + Tcells and ZFP36 in monocytes modulate the protective and risk phenotypes in psoriasis [0.03%]
CEBPD调控的CD8+S100B+T细胞和ZFP36调控的单核细胞的细胞类型特异性因果效应可调节银屑病的保护表型和风险表型
Luofei Huang,Jian Shi
Luofei Huang
Psoriasis is a chronic immune-mediated inflammatory skin disease characterized by dysregulated keratinocyte proliferation, immune cell infiltration, and systemic comorbidities. Despite the identification of numerous genetic susceptibility l...
Genome-wide investigations of the lipid accumulation product index pinpoints polygenic determinants underlying pancreatitis susceptibility [0.03%]
全基因组对血脂积聚产物指数的调查确定了遗传易感性急性胰腺炎的多基因决定因素
Chia-Fu Chien,Zhengwei Qi,Zhengye Liu et al.
Chia-Fu Chien et al.
The lipid accumulation product index (LAP) is a robust marker of lipid burden. However, its genetic architecture and causal relevance to pancreatitis remain poorly characterized. We performed a genome-wide association study (GWAS) of LAP in...