Assessing the prospects of genome-wide association studies performed in inbred mice [0.03%]
评估近交系小鼠全基因组关联研究的前景
Wan-Lin Su,Solveig K Sieberts,Robert R Kleinhanz et al.
Wan-Lin Su et al.
The remarkable success in mapping genes linked to a number of disease traits using genome-wide association studies (GWAS) in human cohorts has renewed interest in applying this same technique in model organisms such as inbred laboratory mic...
Genetic resistance to diet-induced obesity in chromosome substitution strains of mice [0.03%]
小鼠染色体置换系中遗传性肥胖抵抗的研究
Lindsay C Burrage,Annie E Baskin-Hill,David S Sinasac et al.
Lindsay C Burrage et al.
Discovery of genes that confer resistance to diseases such as diet-induced obesity could have tremendous therapeutic impact. We previously demonstrated that the C57BL/6J-Chr(A/J)/NaJ panel of chromosome substitution strains (CSSs) is a uniq...
Melissa J Lathrop,Lisa Chakrabarti,Jeremiah Eng et al.
Melissa J Lathrop et al.
Members of the CHD protein family play key roles in gene regulation through ATP-dependent chromatin remodeling. This is facilitated by chromodomains that bind histone tails, and by the SWI2/SNF2-like ATPase/helicase domain that remodels chr...
Serum response factor is essential for the proper development of skin epithelium [0.03%]
血清反应因子对于正常皮肤上皮发育必不可少
Angela M Verdoni,Sakae Ikeda,Akihiro Ikeda
Angela M Verdoni
Mammalian epidermis is a stratified epithelium that serves as a barrier protecting the organism from mechanical stress and dehydration. Previous studies have demonstrated the importance of the actin cytoskeleton in the establishment of a fu...
Whole-genome scan identifies quantitative trait loci for chronic pastern dermatitis in German draft horses [0.03%]
全基因组扫描鉴定德国挽马慢性过去尔病的量化性状位点
E Henrike Mittmann,Stefanie Mömke,Ottmar Distl
E Henrike Mittmann
Chronic pastern dermatitis (CPD), also known as chronic progressive lymphedema (CPL), is a skin disease that affects draft horses. This disease causes painful lower-leg swelling, nodule formation, and skin ulceration, interfering with movem...
Increased physical activity cosegregates with higher intake of carbohydrate and total calories in a subcongenic mouse strain [0.03%]
增加体力活动与亚 congenic 小鼠株系碳水化合物和总热量摄入增高共分离
K Ganesh Kumar,Lisa M DiCarlo,Julia Volaufova et al.
K Ganesh Kumar et al.
C57BL/6 J (B6) and CAST/EiJ (CAST), the inbred strain derived from M. musculus castaneus, differ in nutrient intake behaviors, including dietary fat and carbohydrate consumption in a two-diet-choice paradigm. Significant quantitative trait ...
Microphthalmia, parkinsonism, and enhanced nociception in Pitx3 ( 416insG ) mice [0.03%]
Pitx3(416insG)小鼠微小眼、帕金森病和痛觉过敏模型
Michael Rosemann,Alesia Ivashkevich,Jack Favor et al.
Michael Rosemann et al.
A new spontaneous mouse mutant was characterized by closed eyelids at weaning and without apparent eyes (provisional gene name, eyeless; provisional gene symbol, eyl). The mutation follows a recessive pattern of inheritance and was mapped t...
A method for mapping intralocus interactions influencing excessive alcohol drinking [0.03%]
一种在基因内部位点之间相互作用影响酒精滥用的图谱绘制方法
Tamara J Phillips,Cheryl Reed,Sue Burkhart-Kasch et al.
Tamara J Phillips et al.
Excessive alcohol (ethanol) consumption is the hallmark of alcohol use disorders. The F1 hybrid cross between the C57BL/6J (B6) and FVB/NJ (FVB) inbred mouse strains consumes more ethanol than either progenitor strain. The purpose of this s...
E E Mlynarski,C J Obergfell,M J O&#x;Neill et al.
E E Mlynarski et al.
Multiple Genome Rearrangement (MGR) analysis was used to define the trajectory and pattern of chromosome rearrangement within muroid rodents. MGR was applied using 107 chromosome homologies between Mus, Rattus, Peromyscus, the muroid sister...
Junming Yue,Gabor Tigyi
Junming Yue
MiR-15a/16-1 and miR-15b/16-2 clusters have been shown to play very important roles in regulating cell proliferation and apoptosis by targeting cell cycle proteins and the antiapoptotic Bcl-2 gene. However, the physiological implications of...