MicroRNAs and epigenetic regulation in the mammalian inner ear: implications for deafness [0.03%]
哺乳动物内耳的微小核糖核酸和表观遗传学调控及其对聋病的影响
Lilach M Friedman,Karen B Avraham
Lilach M Friedman
Sensorineural hearing loss is the most common sensory disorder in humans and derives, in most cases, from inner-ear defects or degeneration of the cochlear sensory neuroepithelial hair cells. Genetic factors make a significant contribution ...
Radhika Das,Daniel D Hampton,Randy L Jirtle
Radhika Das
Genomic imprinting results in parent-of-origin-dependent, monoallelic expression of genes. The functional haploid state of these genes has far-reaching consequences. Not only has imprinting been implicated in accelerating mammalian speciati...
Effect of IVF and laser zona dissection on DNA methylation pattern of mouse zygotes [0.03%]
体外受精及激光卵丘质打孔对小鼠单细胞期dna甲基化模式的影响
Dominika D Peters,Konstantin Lepikhov,Karsten Rodenacker et al.
Dominika D Peters et al.
In vitro fertilization (IVF) and zona pellucida laser microdissection-facilitated IVF (Laser-IVF) are presently routine procedures in human assisted reproduction. The safety of these methods at the epigenetic level is not fully understood. ...
Genetic basis of sex-specific resistance to neuro-oncogenesis in (BDIX x BDIV) F(2) rats [0.03%]
雄雌大鼠脑肿瘤遗传易感性的性别差异分析
Bettina Winzen,Bernd Koelsch,Christine Fischer et al.
Bettina Winzen et al.
The identification of cancer susceptibility- and resistance-mediating genes is an essential prerequisite for prevention and early diagnosis of malignant tumors. Model organisms are helpful to identify variant alleles involved in pathways af...
Wallace S Chick,Derek A Drechsel,Warren Hammond et al.
Wallace S Chick et al.
Genetic manipulation of embryonic stem (ES) cells has been used to produce genetically engineered mice modeling human disorders. Here we describe a novel, additional application: selection for a phenotype of interest and subsequent transmis...
Epigenetic mechanisms underlying extinction of memory and drug-seeking behavior [0.03%]
表观遗传调控记忆消退及药物求取行为的机制研究
Melissa Malvaez,Ruth M Barrett,Marcelo A Wood et al.
Melissa Malvaez et al.
An increasing body of evidence shows that structural modifications of chromatin, the DNA-protein complex that packages genomic DNA, do not only participate in maintaining cellular memory (e.g., cell fate), but they may also underlie the str...
A species-generalized probabilistic model-based definition of CpG islands [0.03%]
基于物种通用的概率模型的CpG岛定义
Rafael A Irizarry,Hao Wu,Andrew P Feinberg
Rafael A Irizarry
The DNA of most vertebrates is depleted in CpG dinucleotides, the target for DNA methylation. The remaining CpGs tend to cluster in regions referred to as CpG islands (CGI). CGI have been useful as marking functionally relevant epigenetic l...
RNase 1 genes from the family Sciuridae define a novel rodent ribonuclease cluster [0.03%]
Sciurid家族的RNase 1基因定义了一个新颖的啮齿动物核糖核酸酶簇
Steven J Siegel,Caroline M Percopo,Kimberly D Dyer et al.
Steven J Siegel et al.
The RNase A ribonucleases are a complex group of functionally diverse secretory proteins with conserved enzymatic activity. We have identified novel RNase 1 genes from four species of squirrel (order Rodentia, family Sciuridae). Squirrel RN...
Hugh J French,Rosalind Attenborough,Kristine Hardy et al.
Hugh J French et al.
Our knowledge of regulatory mechanisms of gene expression and other chromosomal processes related to DNA methylation and chromatin state is continuing to grow at a rapid pace. Understanding how these epigenomic phenomena vary between indivi...