Mapping copy number variable regions correlated with reproduction and production traits in Karan Fries cattle mammalian genomics [0.03%]
卡兰 fries牛生殖和生产性状相关拷贝数变异区域的哺乳动物基因组学映射
Oshin Togla,Shivam Bhardwaj,Sagar Kadyan et al.
Oshin Togla et al.
Copy Number Variants (CNVs) are the structural variations influencing more nucleotides when compared to other types of variations, having a greater impact on the regulation of gene expression, dosage of a gene, altering the coding sequences...
Beyond black and white: dissecting the genetic basis of skin depigmentation in Nellore cattle [0.03%]
超越非黑即白：剖析 Nelore 奶牛皮肤脱色的遗传基础
Milena A F Campos,Hinayah Rojas de Oliveira,Gregorio M F de Camargo et al.
Milena A F Campos et al.
Depigmentation defects in cattle are characterized by the absence of pigment in specific skin regions, increasing susceptibility to health issues and often leading to early culling. In Nellore cattle, depigmentation is primarily observed at...
Utilising genomic association data for causal inference in anorexia nervosa [0.03%]
利用基因组关联数据进行厌食症的因果推理
Danielle M Adams,Murray J Cairns
Danielle M Adams
Anorexia nervosa (AN) is a prevalent psychiatric disorder with high rates of mortality and limited treatment options. AN is a complex disorder, for which common variation contributes to disorder risk. To dissect the genetic architecture of ...
Integrative multiomics elucidate crotonylation-associated GCDH in Parkinson's disease pathogenesis via metabolome remodeling [0.03%]
整合多组学阐明通过代谢重塑参与帕金森病病理发生的GCDH相关赖冬酸修饰
Jia Fu,Jing Zhao,Na Mi et al.
Jia Fu et al.
The pathophysiological significance of crotonylation and its metabolomic regulatory circuitry in Parkinson's disease (PD) remains elusive. We utilized Mendelian randomization (MR) frameworks combined with mediation analysis to establish cau...
Multiple omics-based machine learning reveals peripheral blood immune cell landscape during acute rejection of kidney transplantation and constructs a precise non-invasive diagnostic strategy [0.03%]
基于多组学的机器学习揭示了肾移植急性排斥反应外周血免疫细胞图谱并构建精准无创诊断策略
Jiyue Wu,Lijian Gan,Xihao Shen et al.
Jiyue Wu et al.
Kidney transplantation is the optimal treatment for end-stage renal disease (ESRD), but acute rejection (AR) remains a major factor affecting graft survival and patient prognosis. Currently, renal biopsy is the gold standard for diagnosing ...
Low-coverage whole-genome sequencing facilitates accurate and cost-effective haplotype reconstruction in complex mouse crosses [0.03%]
低覆盖率全基因组测序可促进复杂小鼠杂交群的相位准确且经济的重建
Samuel J Widmayer,Lydia K Wooldridge,Emily Swanzey et al.
Samuel J Widmayer et al.
The search for the underlying genetic contributions to complex traits and diseases relies on accurate genetic data from populations of interest. Outbred populations, like the Diversity Outbred (DO), are commonly genotyped using commercial S...
Exploration of shared diagnostic genes and mechanisms between crohn's disease and ischemic stroke by integrated comprehensive bioinformatics analysis and machine learning [0.03%]
基于综合生物信息学分析和机器学习探索克罗恩病与缺血性脑卒中的共有诊断基因及机制
Chunlin Ren,Xinmin Li,Fangjie Yang et al.
Chunlin Ren et al.
Investigating comorbidities of ischemic stroke (IS) enhances understanding of its intricate mechanisms. Crohn's disease (CD) is associated with an increased risk of IS, but the underlying mechanisms remain unclear. This study aims to identi...
Elucidation of novel diagnostic biomarkers and therapeutic targets in colorectal carcinoma: an integrative approach leveraging multi-omics, computational biology, and single-cell sequencing technologies [0.03%]
结直肠癌新型诊断生物标志物和治疗靶点的阐明：整合多组学、计算生物学及单细胞测序技术的方法
Tingyang Li,Yuhua Tian,Yinchuan Wang et al.
Tingyang Li et al.
This study employs a comprehensive, multi-layered analytical approach to comprehensively investigate the pathogenesis, diagnostic methodologies, and potential therapeutic targets of colorectal cancer. Integrating data from the Global Burden...
FOXP2 mediates ZSCAN18 transcriptional activation to inhibit oral squamous cell carcinoma progression by blocking Hedgehog signaling [0.03%]
FOXP2通过抑制Hedgehog信号通路抑制口腔鳞状细胞癌进展中的ZSCAN18转录激活作用
Ling Niu,Guangyao Hu
Ling Niu
Zinc finger and SCAN domain-containing (ZSCAN) family members have been implicated in cancer progression. This paper was to assess the role of ZSCAN18 in oral squamous cell carcinoma (OSCC). The OSCC datasets were obtained from the GEO data...
A review on the mechanism and potential diagnostic application of CRISPR/Cas13a system [0.03%]
CRISPR/Cas13a系统机制及潜在诊断应用研究进展
Abdul Basit,Anjing Liu,Wanglong Zheng et al.
Abdul Basit et al.
Clustered regularly Interspaced short palindromic repeats (CRISPRs) and CRISPR-associated (Cas) proteins form a natural immune defense system in prokaryotic species, with approximately 90% of archaea and 40% of bacteria possessing these sys...