Genome-wide characterization of genetic diversity and breed discrimination markers in Tharparkar cattle [0.03%]
塔帕尔卡尔牛基因组遗传多样性和品种鉴别标记的鉴定
Anal Bose,Nishu Bharia,Sonali Sonejita Nayak et al.
Anal Bose et al.
Tharparkar, an indigenous milch breed from India, is known for producing high-quality milk and being able to thrive in dry and desert settings. This breed is very important for the livelihoods of rural communities. This work aimed to assess...
Affan Shaikh,Martin F Pera
Affan Shaikh
Age-related macular degeneration (AMD) is a major cause of vision loss worldwide. The disease is caused by deterioration of the retinal pigment epithelium (RPE), a tissue that plays critical roles in the support of the photoreceptors. Cell ...
Copy number evolution of conserved noncoding RNA gene families across mammals [0.03%]
哺乳动物中保守的非编码RNA基因家族的拷贝数演化
Zewei Yang,Zixia Huang
Zewei Yang
Noncoding RNAs (ncRNAs) play essential roles in mammalian gene regulation, yet their copy number evolution across mammals remains poorly characterised. Here, using high-confidence Covariate Models (CMs) from Rfam, we applied a unified INFER...
Polyunsaturated fatty acid metabolism in the retinal pigment epithelium and its association with outer retinal disease [0.03%]
多不饱和脂肪酸在视网膜色素上皮中的代谢及其与外层视网膜疾病的关系
Naga Pradeep Rayana,Navdeep Gogna,Mark P Krebs et al.
Naga Pradeep Rayana et al.
Polyunsaturated fatty acids (PUFAs) are essential for photoreceptor (PR) development, structure and function, and their availability in the outer retina is predominantly mediated by the retinal pigment epithelium (RPE), a cellular monolayer...
Junctions in Jeopardy: the neuromuscular junction is a selective pathological target in Charcot-Marie-Tooth disease [0.03%]
危险中的突触：神经肌肉突触在夏科-马里-图奥特病中是可选择的病理靶点
Louisa Snape,James N Sleigh
Louisa Snape
Charcot-Marie-Tooth disease (CMT) is a genetic peripheral neuropathy arising from mutations in diverse genes that principally disrupt axons and Schwann cells. As the most distal synaptic interface of motor neurons, the neuromuscular junctio...
Genomic structural equation modeling reveals the shared genetic architecture of osteosarcopenia across five musculoskeletal phenotypes [0.03%]
基因组结构方程模型揭示了五种肌肉骨骼表型中骨肌减少症的共有遗传结构
Weiqiang Lai,Kaiqin Gong,Ronghao Zhong et al.
Weiqiang Lai et al.
Osteosarcopenia-the concurrent presence of osteoporosis and sarcopenia-affects approximately 18.5% of older adults globally, yet its shared genetic basis remains poorly understood. We applied genomic structural equation modeling (Genomic SE...
Genome-wide DAPC-based genetic structure, linkage disequilibrium, and effective population size in indigenous buffaloes of Northeastern and Central India [0.03%]
基于基因组范围DAPC的东北和中央印度本土水牛遗传结构、连锁不平衡及有效种群大小分析
Swati Rulyan,Udayabanu Malairaman,R K Vijh
Swati Rulyan
The Indian buffalo population makes a significant component of rural livelihood and dairy economics and has different genetic makeup from the diverse evolutionary processes. The purpose of this study is to determine the amount of genomic va...
THBS1: a biomarker for PCOS and its role in pathogenesis via the PI3K/AKT signaling pathway [0.03%]
THBS1在PCOS中的生物标志物作用及其通过PI3K/AKT信号通路参与发病机制的作用
Jie Zhang,Luhongyuan Jin,Chi Chi et al.
Jie Zhang et al.
This study identified thrombospondin-1 (THBS1) as a potential biomarker for polycystic ovary syndrome (PCOS) and its pivotal role in disease pathogenesis through multi-level bioinformatics analysis and experimental validation. By integratin...
Combined single-cell RNA sequencing and mendelian randomization to identify biomarkers associated with circadian rhythm in sarcopenia [0.03%]
结合单细胞RNA测序和孟德尔随机化识别与肌少症昼夜节律相关的生物标志物
Yuli Huang,Lifeng Tang,Daoyuan Li et al.
Yuli Huang et al.
Sarcopenia refers to the involuntary loss of skeletal muscle mass and function with aging and is associated with multiple adverse health outcomes. Disruption of normal circadian rhythms due to shift work or nocturnal lifestyle is associated...
Contrasting the genetic architecture of cardiac glutathione against other organs: unveiling a unique tissue-specific locus [0.03%]
心脏谷胱甘肽与其它器官的遗传结构对比：揭示独特的组织特异性位点
Jessica Strosahl,Susan McClatchy,Gary A Churchill et al.
Jessica Strosahl et al.
Glutathione is a ubiquitous antioxidant with critical roles in xenobiotic clearance and aerobic metabolism. Reduced glutathione (GSH) is converted to its oxidized counterpart, GSSG, in the process of neutralizing free radicals and maintaini...