The natural history of body-first versus brain-first Parkinson's disease subtypes [0.03%]
身体先发 vs. 大脑先发帕金森病亚型的自然史
Vittorio Velucci,Angelo Fabio Gigante,Giovanni Iliceto et al.
Vittorio Velucci et al.
Background: Several lines of evidence support the hypothesis of brain-first and body-first Parkinson's disease (PD) subtypes, characterized by distinct origins of α-synuclein pathology. However, data on premotor non-moto...
Distinct patterns of cerebral and spinal pathology along the spectrum of ATXN2-related disorders [0.03%]
ATXN2相关疾病谱中脑和脊髓病理学的不同特征
Paulo Schneider Wolmer,Fabrício Castro de Borba,Thiago Junqueira Ribeiro de Rezende et al.
Paulo Schneider Wolmer et al.
Background: The ATXN2 gene contains a polymorphic CAG-rich region encoding a polyglutamine tract in ataxin- 2. Normal alleles have fewer than 27 CAG repeats, 27-34 repeats pose a risk for ALS (ATXN2-ALS), and > 34 repeats...
Clinical and MRI features contributing to the clinico-radiological dissociation in a large cohort of people with multiple sclerosis [0.03%]
大规模多发性硬化队列中影响临床影像学分离的临床和磁共振特征
Abhineet Ojha,Silvia Tommasin,Claudia Piervincenzi et al.
Abhineet Ojha et al.
Background: People with Multiple Sclerosis (PwMS) often show a mismatch between disability and T2-hyperintense white matter (WM) lesion volume (LV), that in general is referred to as the clinico-radiological paradox. ...
Structural and functional neuroplasticity in music and dance-based rehabilitation: a systematic review [0.03%]
基于音乐和舞蹈的康复中的结构和功能神经可塑性：系统评价研究
Valeria Blasi,Laura Rapisarda,Diego Michael Cacciatore et al.
Valeria Blasi et al.
Background: Music- and dance-based rehabilitation has gained prominence in promoting social engagement and improving motor, cognitive, and mood domains in individuals affected by different neurological disorders. ...
Tenecteplase compared to alteplase before mechanical thrombectomy enhances 1-h recanalization and reduces disability in large-vessel occlusion [0.03%]
与机械取栓前使用阿替普酶相比，使用尼莫地平前列环素可提高大型血管闭塞患者1小时再通率并减少残疾
Lu Wang,Jialu Li,Xiao Wu et al.
Lu Wang et al.
Background: The comparative efficacy of tenecteplase versus alteplase in achieving early recanalization (ER) before mechanical thrombectomy (MT) for large-vessel occlusion (LVO) remains uncertain. ...
Comparative Study
Journal of neurology. 2025 Apr 9;272(5):324. DOI:10.1007/s00415-025-13084-2 2025
Longitudinal description of health-related quality of life and depressive symptoms in polyQ spinocerebellar ataxia patients [0.03%]
多聚谷氨酰胺脊髓小脑共济失调患者的健康相关生活质量及抑郁症状的纵向描述
Audrey Iskandar,Maresa Buchholz,Iris Blotenberg et al.
Audrey Iskandar et al.
Introduction: Due to limited treatment options, managing symptoms has dominated care for Spinocerebellar Ataxia (SCA). Little attention has been given to health-related quality of life (HRQoL) and depressive symptoms expe...
A cross-sectional survey on the health status of patients with Charcot-Marie-Tooth disease in a Chinese national patient group [0.03%]
中国查尔斯-托特病患者协会成员健康状况的横断面调查研究
Shimiao Dai,Jiayin Zheng,Yuqing Chen et al.
Shimiao Dai et al.
Background: Charcot-Marie-Tooth disease (CMT) is a rare inherited peripheral neuropathy, and the health status of CMT patients in China is not well understood without a national disease registry system. We aimed to obtain...
Motor, affective, cognitive, and perceptual symptom changes over time in individuals with Parkinson's disease who develop freezing of gait [0.03%]
帕金森病伴步态冻结患者的症状变化特征：一项纵向研究
Michelle V Faerman,Cayli Cole,Karen Van Ooteghem et al.
Michelle V Faerman et al.
Freezing of gait (FOG) affects up to 80% of individuals living with advanced Parkinson's disease and approximately 20% in early stages. Associated with motor, affective, cognitive, and sensory difficulties, FOG is challenging to treat due t...
Neural correlates of β-lactam exposure in intensive care unit patients: an observational, prospective cohort study [0.03%]
头孢曲松暴露在重症监护病房患者的神经效应：一项观察性前瞻性队列研究
Arnaud Zalta,Agnès Trébuchon,Géraldine Daquin et al.
Arnaud Zalta et al.
Background: β-lactam-induced neurotoxicity in critical care patients can compromise clinical outcomes. Despite the growing use of therapeutic drug monitoring (TDM) for β-lactams, clear toxicity thresholds remain undefin...
Observational Study
Journal of neurology. 2025 Apr 7;272(5):320. DOI:10.1007/s00415-025-13067-3 2025
HyperCKemia and rhabdomyolysis following lacosamide initiation: two case reports [0.03%]
拉考沙胺初次使用后发生高血清肌酸激酶血症和横纹肌溶解症：2例报告
Guido Bonelli,Gianni Cutillo,Sebastiano Galantucci et al.
Guido Bonelli et al.