Need for awareness and surveillance of long-term post-COVID neurodegenerative disorders. A position paper from the neuroCOVID-19 task force of the European Academy of Neurology [0.03%]
关于建立新冠长期后遗症神经退行性疾病意识和监测的必要性。欧洲神经病学学院neuroCOVID-19特别工作组立场文件
Dániel Bereczki,Ádám Dénes,Filippo M Boneschi et al.
Dániel Bereczki et al.
Background: Neuropathological and clinical studies suggest that infection with SARS-CoV-2 may increase the long-term risk of neurodegeneration. Methods: ...
Core diagnostic features of stiff person syndrome: insights from a case-control study [0.03%]
僵人综合征的核心诊断特征：病例对照研究的启示
Shuvro Roy,Yishang Huang,Chen Hu et al.
Shuvro Roy et al.
Background: Stiff person syndrome spectrum disorders (SPSD) are rare, disabling neuroimmunological conditions with no consensus diagnostic criteria, making diagnosis challenging. Misdiagnosis often occurs due to the limit...
Andrew J Larner
Andrew J Larner
Aging and the neuropsychiatry of multiple sclerosis: a cross-sectional study [0.03%]
多发性硬化神经精神症状与年龄的关系：横断面研究
David E Freedman,Jiwon Oh,Gillian Einstein et al.
David E Freedman et al.
Aging in multiple sclerosis (MS) affects clinical and radiological disease activity. Yet, evidence is equivocal about the effects of aging on the neuropsychiatric sequelae of MS, including anxiety, depression, fatigue, and cognitive dysfunc...
Intrathecal methotrexate in progressive multiple sclerosis: a phase 1 open-label study with long-term follow-up [0.03%]
大篇幅随访的开放性I期研究：肌内甲氨蝶呤治疗进行性多发性硬化症
Hadar Kolb,Yuval Shachaf,Karin Fainberg et al.
Hadar Kolb et al.
Progressive multiple sclerosis (PMS) remains challenging to treat effectively. Intrathecal methotrexate (ITMTX) has emerged as a potential therapy for alleviating PMS symptoms. This study aimed to assess the safety, tolerability, and effica...
Clinical Trial
Journal of neurology. 2025 May 4;272(5):374. DOI:10.1007/s00415-025-13114-z 2025
Age at onset of epilepsy shapes neurocognitive profiles in focal cortical dysplasia [0.03%]
发病年龄影响局灶性皮层发育不良患者的神经认知功能
Anna-Laura Potthoff,Lukas Tennie,Juri-Alexander Witt et al.
Anna-Laura Potthoff et al.
Background: Focal cortical dysplasia (FCD) is a common developmental brain disorder frequently associated with refractory epilepsy and neurocognitive comorbidities. This study examines the neurocognitive profiles of patie...
Analyzing recurrent events in multiple sclerosis: a review of statistical models with application to the MSOAC database [0.03%]
多发性硬化症复发事件的统计模型分析：MSOAC数据库的应用研究
David Herman,Julien Tanniou,Emmanuelle Leray et al.
David Herman et al.
Patients with multiple sclerosis (MS) are susceptible to experience recurrent events of disability progression and relapses. Many studies still focus on analyzing MS events with traditional methods such as Cox proportional hazards, Poisson,...
Pathological laugher and crying in motor neuron diseases: a matter of bulbar and neurobehavioral involvement with sex imbalance [0.03%]
Motor神经疾病的病理性的笑声和哭泣：与球部和神经行为异常以及性别不平衡有关的事宜
Veronica Faltacco,Eleonora Dalla Bella,Anna Nigri et al.
Veronica Faltacco et al.
Background: Emotional lability (EL), also known as pathological laughter and crying, is a common but understudied symptom in motor neuron diseases (MND): amyotrophic lateral sclerosis and primary lateral sclerosis. This s...
Mortality and causes of death for people with multiple sclerosis: a Finnish nationwide register study [0.03%]
芬兰全国登记处的多发性硬化症患者的死亡率和死亡原因研究
Katariina Kuutti,Sini M Laakso,Matias Viitala et al.
Katariina Kuutti et al.
Introduction: Population-based longitudinal data on mortality and causes of death (COD) for people with Multiple Sclerosis (pwMS) is scarce. We studied all-cause and cause-specific mortality in Finnish pwMS in a nationwid...
Impact of LRRK2 and GBA variants on orthostatic hypotension in patients with Parkinson's disease [0.03%]
LRRK2和GBA基因变异对帕金森病患者直立性低血压的影响
Wen Liu,Yinlian Han,Yuqian Liu et al.
Wen Liu et al.
Backgroud: Orthostatic hypotension (OH) is not rare in patients with Parkinson's disease (PD). To date, there have been few studies on the association of genetic variants with OH. ...