Neuropathological examination of 12 cases of familial Parkinson's disease with LRRK2 I2020T mutation including tau and TDP-43 pathology [0.03%]
LRRK2 I2020T突变帕金森病家系12例尸检，包括tau和TDP-43病理检测结果分析
Akiko Uchino,Kazuko Hasegawa,Saburo Yagishita et al.
Akiko Uchino et al.
We previously reported a clinicopathological examination in the Sagamihara family, familial PD with LRRK I2020T mutation, highlighting the most common neuropathological finding as pure nigral degeneration without Lewy bodies (LBs). We appli...
Monitoring anti-Rituximab antibodies in myasthenia gravis affects the time to event during Rituximab treatment [0.03%]
在使用利妥昔单抗治疗期间监测抗利妥昔单抗抗体可影响患者的事件发生时间
Charlotte Héraud,Saskia Bresch,Véronique Bourg et al.
Charlotte Héraud et al.
Introduction: Rituximab (RTX) effectively manages myasthenia gravis (MG) by reducing relapse rates. Anti-Rituximab antibodies can develop in autoimmune diseases and may lead to RTX resistance. Although RTX infusions are i...
Characterisation of a large, single-centre cohort of patients with Becker muscular dystrophy to inform standardised care guidelines [0.03%]
对Becker型肌营养不良症患者的大规模单中心队列进行特征分析，以制定标准化的治疗指南
Pietro Riguzzi,Holly Borland,Meredith K James et al.
Pietro Riguzzi et al.
Aims: This retrospective, cross-sectional study aimed to characterise a large cohort of paediatric and adult patients with Becker muscular dystrophy (BMD) to inform clinical care. ...
Effectiveness of perampanel as only concomitant antiseizure medication for highly active epilepsy: insight from a real-world, multicenter retrospective study [0.03%]
佩维帕尼单药用于难治性癫痫的疗效分析：一项真实世界多中心回顾性研究的启示
Angelo Pascarella,Marilisa Pasquale,Domenico Abelardo et al.
Angelo Pascarella et al.
Introduction: Managing patients with highly frequent seizures poses significant challenges for clinicians due to their high resistance to therapy. This study aims to evaluate the 12-month efficacy, safety, and tolerabilit...
Observational Study
Journal of neurology. 2025 Jun 7;272(7):449. DOI:10.1007/s00415-025-13184-z 2025
Serological analysis of gluten-related antibodies in idiopathic neuropathies and cerebellar ataxia [0.03%]
特发性神经病和小脑共济失调患者的胶质相关自身抗体检测分析
Maxine D Rouvroye,Janna Warendorf,Alexander Vrancken et al.
Maxine D Rouvroye et al.
Immune reactivity to gluten in the development of peripheral neuropathies and cerebellar ataxia has been suggested for decades, but evidence is scarce. The aim of the current study was to test the prevalence of tissue transglutaminase 2 (an...
Potential use of the SARS-CoV-2 monoclonal antibody sipavibart in people with multiple sclerosis: definition of different patient archetypes from an Italian expert group perspective [0.03%]
一种针对SARS-CoV-2的单克隆抗体sipavibart在多发性硬化患者中的潜在应用：意大利专家小组视角下不同患者的分型定义
Chiara Zanetta,Claudio Gasperini,Maria Pia Amato et al.
Chiara Zanetta et al.
Introduction: Immunocompromised people, including people with MS (PwMS) remain at increased risk of severe COVID-19 outcomes, highlighting how this population needs additional preventive measures beyond current vaccinatio...
A disproportionality analysis of nervous system adverse events associated with disease-modifying therapies in multiple sclerosis: insights from the FDA adverse event reporting system (FAERS) [0.03%]
基于FDA不良事件报告系统(FDA不良事件报告系统(FAERS))的多发性硬化症疾病修正疗法相关神经系統不良反应 disproportionality 分析
Hui Chen
Hui Chen
Background: Disease-modifying therapies (DMTs) have significantly improved the management of multiple sclerosis (MS), but their potential nervous system adverse events (AEs) remain a critical concern. This study aims to e...
Correction: In multiple sclerosis patients a single serum neurofilament light chain (sNFL) dosage is strongly associated with 12 months outcome: data from a real-life clinical setting [0.03%]
纠正：在多发性硬化症患者中，单一血清神经丝轻链（sNFL）剂量与12个月的结果有很强的关联：来自真实临床环境的数据
Simona Malucchi,Cecilia Irene Bava,Paola Valentino et al.
Simona Malucchi et al.
Published Erratum
Journal of neurology. 2025 Jun 4;272(6):444. DOI:10.1007/s00415-025-13107-y 2025
Concomitant anti-CGRP and immunomodulatory treatments in patients with migraine: towards integrated management strategies [0.03%]
偏头痛患者的抗CGRP和免疫调节联合治疗：迈向综合管理策略
María Clara García-Castillo,Álvaro Sierra-Mencía,Edoardo Caronna et al.
María Clara García-Castillo et al.
Background: Preclinical evidence supports the immunoregulatory role of calcitonin gene-related peptide (CGRP) in migraine pathophysiology. The increasing use of anti-CGRP therapies in patients with migraine and other como...
Multicenter Study
Journal of neurology. 2025 Jun 3;272(6):443. DOI:10.1007/s00415-025-13177-y 2025
Impact of the intronic RFC1 expansion size in CANVAS phenotype: an oculomotor study [0.03%]
CANVAS表型的内含子RFC1扩展大小对眼肌的影响：一项眼肌研究
Mathieu Dupré,Ruben Hermann,Léo Vidoni et al.
Mathieu Dupré et al.
The identification of the RFC1 homozygous intronic expansion in cerebellar ataxia neuropathy and vestibular areflexia syndrome (CANVAS) highlighted that genetically determined CANVAS patients exhibit a wide range of clinical presentations a...