Added value of spinal cord MRI in detecting active disease in non-relapsing progressive multiple sclerosis patients [0.03%]
脊髓MRI在非复发行多发性硬化症患者中检测活动性疾病的价值
Marco Vercellino,S Marasciulo,C Bosa et al.
Marco Vercellino et al.
Introduction: Spinal cord MRI is not routinely recommended in the monitoring of MS. In patients with progressive MS (pMS), presence of disease activity is an important predictor of treatment response to currently approved...
Mitochondrial pathology in inflammatory myopathies: a marker of worse clinical outcome [0.03%]
线粒体病理在炎性肌病中的临床意义：预后不良的标志
Antonio Lauletta,Luca Bosco,Gioia Merlonghi et al.
Antonio Lauletta et al.
Objectives: Mitochondrial dysfunction is well documented in inclusion body myositis (IBM), but its role in non-IBM myositis remains unclear. This study aimed to investigate the prevalence and clinical significance of mito...
Multicenter Study
Journal of neurology. 2025 Jun 26;272(7):480. DOI:10.1007/s00415-025-13192-z 2025
Regional free-water diffusion is more strongly related to neuroinflammation than neurodegeneration [0.03%]
区域自由水弥散与神经炎症的关系比与神经退行性的关系更密切
Vishaal Sumra,Mohsen Hadian,Allison A Dilliott et al.
Vishaal Sumra et al.
Introduction: Recent research has suggested that neuroinflammation may be important in the pathogenesis of neurodegenerative diseases. Free-water diffusion (FWD) has been proposed as a non-invasive neuroimaging-based biom...
Andrew J Larner
Andrew J Larner
Andrew J Larner
Andrew J Larner
A multi-domain lifestyle intervention in multiple sclerosis: a longitudinal observational study [0.03%]
多发性硬化症的多领域生活方式干预：一项纵向观察性研究
Ilse M Nauta,Keeva N M Loughlin,Arianne S Gravesteijn et al.
Ilse M Nauta et al.
Objective: To examine the effects of a multi-domain lifestyle intervention that advocated a Mediterranean style diet, and concurrently targeted physical activity, stress and sleep, on multiple sclerosis. ...
Observational Study
Journal of neurology. 2025 Jun 24;272(7):476. DOI:10.1007/s00415-025-13196-9 2025
Quantitative cervical cord MRI in spinal muscular atrophy: a sensitive imaging biomarker of disease evolution and treatment [0.03%]
脊髓性肌萎缩的颈椎磁共振成像定量分析：一种有效的疾病发展及治疗影像生物标志物
C Asteggiano,L Mazzocchi,L Farina et al.
C Asteggiano et al.
Background: Nusinersen is an approved disease-modifying therapy for spinal muscular atrophy (SMA), a rare neuromuscular disease characterized by degeneration of alpha motor neurons in the brainstem and spinal cord (SC), l...
Autosomal recessive Bethlem myopathy: a 30-year journey [0.03%]
常染色体隐性Bethlem型先天性肌病的临床特征及基因型-表型相关性的三十年研究历程
Annamaria Gallone,Giorgia Riolo,Alessandra Ruggieri et al.
Annamaria Gallone et al.
Comparative efficacy and safety of different durations of dual antiplatelet therapy in acute minor non-cardioembolic stroke: a systematic review and network meta-analysis [0.03%]
急性轻微非心源性卒中双联抗血小板治疗不同疗程的疗效和安全性：系统评价和网络 meta 分析
Wuchaonan Liu,Shengping Luo,Ruiyu Huang et al.
Wuchaonan Liu et al.
Background: International guidelines recommend short-course dual antiplatelet therapy (DAPT) for secondary prevention in patients with acute minor stroke. However, the optimal duration of such therapy remains unclear. Thi...
KCNT1 gene variant-associated epilepsy: genetic insights, functional mechanisms, and emerging therapies [0.03%]
KCNT1基因突变相关癫痫：遗传学见解、功能机制及新兴疗法
Ya-Ze Duan,Tong-Tong Yao,Yi-Ting Shao et al.
Ya-Ze Duan et al.
KCNT1 gene variant-associated epilepsy is a rare genetic disorder with a wide clinical spectrum, ranging from mild symptoms to severe, early onset epileptic encephalopathies. It is commonly characterized by focal seizures, drug resistance, ...