Comparative effectiveness of teriflunomide and ocrelizumab on smoldering activity in multiple sclerosis: an observational study in the Swiss Multiple Sclerosis Cohort [0.03%]
特立氟咪和奥瑞珠单抗在多发性硬化症患者中的比较有效性：来自瑞士多发性硬化症队列的一项观察性研究
Alessandro Cagol,Sabine Schaedelin,Mario Ocampo-Pineda et al.
Alessandro Cagol et al.
Background: This study aimed to compare the effects of teriflunomide and ocrelizumab on clinical and MRI endpoints related to smoldering activity in relapsing-remitting multiple sclerosis (RRMS). ...
Observational Study
Journal of neurology. 2025 Jul 2;272(8):491. DOI:10.1007/s00415-025-13221-x 2025
Frailty diminishes functional outcome in patients with nonaneurysmal subarachnoid hemorrhage: a dual specialized neurovascular center analysis [0.03%]
虚弱会降低非动脉瘤性蛛网膜下腔出血患者的预后：来自两家专业神经血管中心的分析结果
Larissa Penner,Anna-Laura Potthoff,Tim Lampmann et al.
Larissa Penner et al.
Objective: Frailty is increasingly recognized as a significant prognostic factor in various conditions. However, its impact on outcomes following spontaneous, nonaneurysmal subarachnoid hemorrhage (naSAH) remains unclear....
Multicenter Study
Journal of neurology. 2025 Jul 2;272(8):488. DOI:10.1007/s00415-025-13227-5 2025
Yinxiang Wang,Jianfei Nao,Yingjie Duan et al.
Yinxiang Wang et al.
Myasthenia gravis (MG) is an acquired autoimmune disorder characterized by impaired neuromuscular junction transmission, leading to fluctuating muscle weakness. With the progressive identification of MG-related antibodies, such as acetylcho...
Multiparametric MRI-based biomarkers in the non-fluent and semantic variants of primary progressive aphasia [0.03%]
原发进行性失语非流利变异型和语义变异型的多参数MRI生物标志物研究
Marco Michelutti,Hans-Jürgen Huppertz,Heiko Volkmann et al.
Marco Michelutti et al.
Background: The non-fluent (nfPPA) and semantic (svPPA) variants of primary progressive aphasia exhibit distinct clinical features. We investigated whether diffusion tensor imaging (DTI) and atlas-based volumetry (ABV) co...
Genetic variation of low-to-medium-affinity Fc-gamma receptors in Guillain-Barré syndrome [0.03%]
低中亲和力Fc-γ受体在吉兰-巴雷综合征中的遗传变异
Sander J van Tilburg,Selin Koçer,Judy Geissler et al.
Sander J van Tilburg et al.
Introduction: Fc-gamma receptors (FcγRs) are important for the effector functions of immunoglobulin G (IgG) and are therefore expected to play a role in the pathophysiology of Guillain-Barré syndrome (GBS). The FCGR2/3 ...
Insight into NeuroCOVID: neurofilament light chain (NfL) as a biomarker in post-COVID-19 patients with olfactory dysfunctions [0.03%]
神经轻链蛋白（NfL）在嗅觉障碍的新冠患者中的生物标志物作用研究
Fiorenza Pennacchia,Federica Zoccali,Carla Petrella et al.
Fiorenza Pennacchia et al.
The term NeuroCOVID was coined to describe the neurological consequences observed in COVID-19 patients. Numerous patients infected with SARS-CoV-2 reported olfactory dysfunction as the first symptom preceding clinical manifestations, such a...
Salvatore Maria Lima,Nicasio Rini,Andrea Calì et al.
Salvatore Maria Lima et al.
Stiff-person syndrome (SPS) is a rare autoimmune neurological disorder characterized by high titers of antibodies against glutamic acid decarboxylase (GAD) and impaired GABAergic inhibitory neurotransmission. If not promptly treated, SPS pr...
Comparative efficacy and safety of irreversible (rasagiline) and reversible (safinamide) monoamine oxidase inhibitors as add-on therapy for Parkinson's disease [0.03%]
不可逆型（雷沙吉兰）和可逆型单胺氧化酶抑制剂作为帕金森病联合治疗药物的疗效及安全性比较研究
Marwah Bintay Khalid,Faizan Shahzad,Momina Riaz Siddiqui et al.
Marwah Bintay Khalid et al.
Background: Parkinson's disease (PD) is a progressive, neurodegenerative condition caused by progressive loss of dopaminergic neurons of the substantia nigra. Safinamide and rasagiline are both novel medications that are ...
Equity in neuromuscular research: a 20-year analysis of race, ethnicity, sex, and age representation [0.03%]
肌无力研究中的公平性问题：对过去20年中种族、族裔、性别和年龄代表性情况的分析
Lorenzo Fontanelli,Gabriele Vadi,Gabriele Bellini et al.
Lorenzo Fontanelli et al.
Objectives: We conducted a systematic analysis of studies on neuromuscular diseases registered on ClinicalTrials.gov over the last 20 years to assess disparities in study populations. ...
Long-term effectiveness and safety of ocrelizumab: a single-centre real-world study [0.03%]
奥法木单抗的长期疗效及安全性：一项单一中心真实世界研究
Tiziana Zaccone,Lucia Moiola,Simone Guerrieri et al.
Tiziana Zaccone et al.
Background: This retrospective single-centre study evaluated the effectiveness and safety of ocrelizumab (OCR) in relapse-onset multiple sclerosis (RMS) and primary progressive MS (PPMS) and identified predictors of treat...