Efficacy and safety of avalglucosidase alfa in patients with late-onset Pompe disease after 145 weeks of treatment during the COMET trial [0.03%]
α-葡萄糖苷酸阿法在晚期庞贝病患者中的有效性和安全性：COMET试验中145周治疗的結果
Priya S Kishnani,Jordi Díaz-Manera,Sergey Illarioshkin et al.
Priya S Kishnani et al.
Background and objectives: In the COMET trial, avalglucosidase alfa treatment for late-onset Pompe disease was safe, tolerable and associated with stabilization or improvement in disease parameters through 97 weeks. We re...
Improving conscientiousness through a smartphone app and telecoaching intervention: insights from multiple sclerosis and healthy aging samples [0.03%]
通过智能手机应用程序和远程教练干预提高责任心：来自多发性硬化症和健康老龄化样本的见解
Michael Jaworski rd,Jacob Balconi,Celeste Santivasci et al.
Michael Jaworski rd et al.
Lower Conscientiousness is associated with cognitive decline, unemployment, and poorer health outcomes in both neurological and aging populations. This study evaluated a smartphone-based intervention to enhance Conscientiousness in people w...
Multimodal quantitative analysis guides precise preoperative localization of epilepsy [0.03%]
多模态定量分析可指导术前精确诊断癫痫定位
Yuanzhong Shen,Zijian Shen,Yimin Huang et al.
Yuanzhong Shen et al.
Epilepsy surgery efficacy is critically contingent upon the precise localization of the epileptogenic zone (EZ). However, conventional qualitative methods face challenges in achieving accurate localization, integrating multimodal data, and ...
MRI-based human brain atlases of R1, R2, proton density, and myelin volume fraction using synthetic quantitative imaging at 1.5 T [0.03%]
基于MRI的人脑图谱R1、R2、质子密度和髓鞘体积分数的合成定量成像在1.5特斯拉下的应用
Hasan Sbaihat,Katharina Roenneke,Dajana Müller et al.
Hasan Sbaihat et al.
Quantitative MRI (qMRI) enables objective, reproducible measurement of tissue-specific MR properties, offering improved diagnostic accuracy and deeper insight into disease mechanisms compared to conventional MRI. Parameters such as proton d...
Impact of expanded Thrombolysis in Cerebral Infarction (eTICI) grades on clinical outcomes in patients with large ischemic strokes receiving endovascular treatment [0.03%]
扩大版的脑梗死溶栓（eTICI）评分对接受血管内治疗的大范围缺血性卒中患者的临床预后影响
Miao Chai,Qin Wan,Linyu Li et al.
Miao Chai et al.
Objective: This study aimed to investigate the impact of the expanded Thrombolysis in Cerebral Infarction (eTICI) grades on clinical outcomes after endovascular treatment (EVT) for large ischemic strokes. ...
Systemic mitochondrial involvement in mitochondrial myopathy with episodic hyper-creatine kinase-emia: insights from an autopsy case [0.03%]
线粒体肌病伴周期性高血清肌酸激酶综合征的系统性线粒体损伤：一例尸检报告的启示
Risa Nagatomo,Yu Hiramatsu,Yusuke Sakiyama et al.
Risa Nagatomo et al.
A systematic study of the distribution and expression of aquaporin water channels in normal adult human brain [0.03%]
人正常成人脑水通道蛋白的分布与表达的系统研究
Reginald C Adiele,Mylyne Tham,Claudia F Lucchinetti et al.
Reginald C Adiele et al.
Backgrounds: Water regulation in the central nervous system (CNS) is very important to maintain normal neurophysiological homeostasis and intracranial pressure, as well as during neuropathological conditions. Not only bec...
Comparing human versus artificial intelligence for health literacy among patients with neurological disorders (HANDs study) [0.03%]
神经疾病患者中的健康素养：人工智能力优于人类吗（HANDs研究）
Carolina Soares,Carolina Correia,Rita Nunes Rato et al.
Carolina Soares et al.
CSF phospho-tau levels at Parkinson's disease onset predict the risk for development of motor complications [0.03%]
帕金森病早期脑脊液磷酸化tau水平预测运动并发症发病风险
Jacopo Bissacco,Giulia Di Lazzaro,Roberta Bovenzi et al.
Jacopo Bissacco et al.
Background: Motor complications (MC), including fluctuations, represent a disabling milestone of Parkinson's disease (PD) course, although the underlying early pathophysiological mechanisms remain unclear. We therefore in...
A review of the link between the lactate-GPR81 axis and mitochondrial angiopathy in MELAS based on imaging characteristics [0.03%]
基于影像特征下线粒体血管病与乳酸-GPR81轴之间联系的探讨
Yuhao Zhao,Dianxuan Chen,Hailing Chen et al.
Yuhao Zhao et al.
The differential diagnosis between Mitochondrial Encephalomyopathy, Lactic Acidosis, and Stroke-like Episodes (MELAS) and acute ischemic stroke (AIS) is frequently confounded by the profound vascular heterogeneity inherent to MELAS, exempli...