Progression of cognitive and functional decline before and after stroke: evidence from four prospective cohort studies across 23 countries [0.03%]
来自23个国家四个人群队列研究的证据：卒中前后认知和功能衰退的进展
Yuxin Cai,Chongyang Duan,Shuyang Wen et al.
Yuxin Cai et al.
Background and purpose: Previous studies had inconsistent results and often lacked pre-stroke cognitive assessments, hindering differentiation between stroke-related decline and normal ageing. To address this, we aimed to...
Altered pedunculopontine pathways in freezing of gait: a diffusion tensor imaging study based on dopaminergic degeneration status [0.03%]
基于多巴胺能神经退行性变的扩散张量成像研究冻结步态患者的脑干相关通路异常
Hee Jin Chang,Huijin Song,Chul-Ho Sohn et al.
Hee Jin Chang et al.
Background: Freezing of gait (FOG), a transient cessation of walking, is commonly observed in various neurodegenerative diseases and linked to pedunculopontine nucleus (PPN) pathway dysfunction. However, it remains unclea...
Single-cell RNA sequencing of cerebrospinal fluid immune cells in relapsing-remitting multiple sclerosis: insights into cellular composition and immune dynamics [0.03%]
复发缓解型多发性硬化脑脊液免疫细胞的单细胞RNA测序：对细胞组成和免疫动态的见解
Xue Yang,Fanju Li,Jingtian Zhe et al.
Xue Yang et al.
Background: Relapsing-remitting multiple sclerosis (RRMS) is a chronic autoimmune disease characterized by episodic inflammation and demyelination within the central nervous system. Recent advances in single-cell RNA sequ...
The brief repeatable battery of neuropsychological test (BRB-N) version B: update of Italian normative data [0.03%]
神经心理简短可重复测验集（BRB-N）版本B：意大利标准数据更新版
Nicolò Tedone,Marta Grosselle,Emilio Portaccio et al.
Nicolò Tedone et al.
Background: Cognitive impairment affects up to 70% of people with multiple sclerosis (PwMS), mainly impacting memory, processing speed and attention. The Brief Repeatable Battery of Neuropsychological Tests (BRB-N) is wid...
Safety of disease-modifying therapies in multiple sclerosis: real-world data from the Austrian MS Treatment Registry (AMSTR) [0.03%]
奥地利多发性硬化治疗注册中心(AMSTR)的疾病修正疗法的安全性：真实世界的数据
Tobias Monschein,Helena Untersteiner,Markus Ponleitner et al.
Tobias Monschein et al.
Background: In the therapeutic landscape of multiple sclerosis (MS), more than a dozen disease-modifying therapies (DMT) are currently available. In Austria, only certified MS centers are authorized to prescribe DMT and a...
Assessment of IBM-FRS total score and specific functional domains in a large cohort of inclusion body myositis patients [0.03%]
评估IBM-FRS总分及特定功能领域在众多包涵体肌炎患者中的表现
Alex Vicino,Antonio Lauletta,Silvia Bonanno et al.
Alex Vicino et al.
Inclusion body myositis (IBM) is an acquired myopathy of older adults, associated with progressive weakness and functional limitations. The inclusion body myositis functional rating score (IBM-FRS) is a reliable tool for the assessment of d...
Multicenter Study
Journal of neurology. 2025 Nov 19;272(12):775. DOI:10.1007/s00415-025-13516-z 2025
Unveiling a silent threat: slowly expanding spinal cord lesion linked to clinical worsening in multiple sclerosis: a case report [0.03%]
渐进性脊髓病变与多发性硬化临床症状进展相关：一例报道
Maria Sofia Martire,Irene Gattuso,Paolo Vezzulli et al.
Maria Sofia Martire et al.
Therapeutic impact of leuprorelin acetate on spinal and bulbar muscular atrophy: pre- and post-marketing observational study [0.03%]
醋酸亮丙瑞林治疗脊髓和延髓肌萎缩症的疗效：一项上市前和上市后观察性研究
Atsushi Hashizume,Ryoichi Hanazawa,Shinichiro Yamada et al.
Atsushi Hashizume et al.
Although leuprorelin acetate, a luteinizing hormone-releasing hormone agonist, has been approved based on short-term clinical trials conducted in Japan, its long-term efficacy on physical function remains unclear. We aimed to evaluate the l...
Observational Study
Journal of neurology. 2025 Nov 19;272(12):772. DOI:10.1007/s00415-025-13509-y 2025
Severe attacks and worse prognosis in patients with late-onset neuromyelitis optica spectrum disorder highlight the need for early highly effective treatment [0.03%]
NMOSD晚期发病患者的严重发作及预后不良提示需早期使用高效治疗药物
Rui Wang,Xiaofei Wang,Ziyan Shi et al.
Rui Wang et al.
Background and objectives: Patients with late-onset neuromyelitis optica spectrum disorder (LO-NMOSD) have a worse prognosis than those with early onset NMOSD (EO-NMOSD), with limited immunotherapy data for patients with ...
Martina Putzolu,Elisabetta Sarasso,Elisa Canu et al.
Martina Putzolu et al.
Introduction: Gait integrates sensorimotor and affective processes, serving both locomotor function and emotional expression. This embodiment framework has clinical relevance in neurodegenerative disorders and suggests po...