Neurological immune-related adverse events of immune checkpoint inhibitors: clinical and hematological risk factors [0.03%]
免疫检查点抑制剂相关神经性免疫不良反应的临床和血液学风险因素
Luca Marsili,Jesus Abanto,Samuel B Marcucci et al.
Luca Marsili et al.
Background: Immune checkpoint inhibitors (ICIs) have revolutionized cancer treatment, but can induce neurological immune-related adverse events (n-irAEs). ...
Novel missense ALDH18A1 variant in a family with autosomal dominant spastic paraplegia [0.03%]
一个新的ALDH18A1错义变异导致常染色体显性遗传的双下肢痉挛性瘫痪
Federica Novarella,Alessandra Tessa,Chiara Criscuolo et al.
Federica Novarella et al.
Objectives: We aim to characterize a novel heterozygous missense variant c.1703A > G/p. (Gln568Arg) in the ALDH18A1 gene, identified in a family with autosomal dominant hereditary spastic paraplegia (HSP). We evaluated cl...
Anchor-based evaluation of digital motor biomarkers from a 2-year observation in 100 patients with multiple sclerosis [0.03%]
基于标记的数字运动生物标志物评估：来自100例多发性硬化患者2年观察结果
Carla A Ellinghaus,Hanna M Röhling,Eva-Maria Dorsch et al.
Carla A Ellinghaus et al.
Background: Description of disease progression in MS lack sensitive clinical outcomes. Digital motor outcomes (DMO) offer potential but require thorough validation. ...
Observational Study
Journal of neurology. 2025 Dec 4;273(1):4. DOI:10.1007/s00415-025-13541-y 2025
Feasibility of a smartphone application for remote use in spastic ataxias: an 8-week long-term PROSPAX study [0.03%]
远程应用智能手机应用程序进行痉挛性共济失调研究的可行性：为期8周的长期PROSPAX研究
Ilse H J Willemse,Sabato Mellone,Carlo Tacconi et al.
Ilse H J Willemse et al.
Background: Digital biomarkers show significant potential and are emerging as outcome measures in clinical trials in spastic ataxias (SPAX). Research on the performances of digital biomarkers in home environments remains ...
Anna Karin Hedström,Tomas Olsson,Lars Alfredsson
Anna Karin Hedström
Background: Multiple sclerosis (MS) has heterogeneous clinical presentations at onset. We aimed to investigate determinants of MS onset-symptom type, and the prognostic relevance of onset categories for long-term disabili...
Physical activity and Alzheimer's disease risk across genetic susceptibility: a prospective UK Biobank study using accelerometer data [0.03%]
基于UK Biobank的加速仪数据：关于遗传易感性与阿尔茨海默病风险之间关系的前瞻性研究
Seunghee Na,Kenneth Muir,Artitaya Lophatananon et al.
Seunghee Na et al.
Objective: Physical activity (PA) has been associated with reduced Alzheimer's disease (AD) risk, but whether protective effects vary across genetic risk levels remains unclear. Previous studies were limited by self-repor...
Cerebrospinal fluid biomarkers for diagnosis of Parkinson's disease: a systematic review and network meta-analysis [0.03%]
帕金森病脑脊液生物标志物的系统评价和网络 meta 分析
Siming Li,Chen Yang,Jiayi Wu et al.
Siming Li et al.
Objectives: There are multiple cerebrospinal fluid (CSF) biomarkers with potential for distinguishing Parkinson's disease (PD) from atypical parkinsonian syndromes (APSs) and controls; however, consensus on their diagnost...
Correction: Huntington's disease in MENAT: systematic review and meta-analysis of prevalence, clinical features, and genetics [0.03%]
中东及北非地区亨廷顿舞蹈病的系统评价和meta分析（标书）
Sohaila Alshimemeri,Abdullah M Shadid,Othman Aldraihem et al.
Sohaila Alshimemeri et al.
Published Erratum
Journal of neurology. 2025 Nov 29;272(12):791. DOI:10.1007/s00415-025-13500-7 2025
Nomograms integrating cortical morphometric metrics with 3D multi-parametric MRI radiomics for predicting disability progression and cognitive worsening in relapsing-remitting multiple sclerosis: a multi-center validation study [0.03%]
结合皮质形态测量和三维多模态MRI影像组学的预测复发缓解型多发性硬化患者残疾进展和认知恶化的列线图：一项多中心验证研究
Zhuo Wang,Shihang Li,Jinrui Liu et al.
Zhuo Wang et al.
Objective: To develop individualized nomograms integrating cortical morphometric measures with 3D multi-parametric MRI radiomics to predict disability progression (DP) and cognitive worsening (CW) in patients with relapsi...
Multicenter Study
Journal of neurology. 2025 Nov 29;272(12):792. DOI:10.1007/s00415-025-13455-9 2025
Andrew J Larner
Andrew J Larner