Two-year OCT follow-up in multiple sclerosis patients on Ofatumumab shows retinal preservation over non-antiCD20 treatments [0.03%]
为期两年的光学相干断层扫描随访结果显示奥法木单抗治疗患者的视网膜得到保存，优于非AntiCD20疗法
Giacomo Greco,Giovanni Della Porta,Francesco Masi et al.
Giacomo Greco et al.
Introduction: Optical coherence tomography (OCT) can detect neuroaxonal loss in multiple sclerosis (MS) patients, with thinning of the ganglion cell layer (GCL) reflecting neurodegeneration. Ofatumumab (OMB), a subcutaneo...
Observational Study
Journal of neurology. 2026 Jan 10;273(1):77. DOI:10.1007/s00415-025-13611-1 2026
Heterogeneous phenotype and cardiovascular comorbidities in Swedish patients with spinobulbar muscular atrophy [0.03%]
瑞典脊髓球部肌肉萎缩症患者的异质性表型和心血管并发症
Anna-Karin Roos,Simon Forsberg,Erica Stenvall et al.
Anna-Karin Roos et al.
Background: Spinobulbar muscular atrophy (SBMA) is an X-linked neuromuscular disorder characterized by adult-onset progressive muscle atrophy, flaccid paresis, and bulbar palsy. In addition, increasing evidence indicates ...
Demographic, clinical and genetic characteristics of patients with amyotrophic lateral sclerosis from two specialised centres in Austria [0.03%]
奥地利两个专业中心的肌萎缩侧索硬化患者的 demographic、临床和遗传特征
Omar Keritam,Vera Elisabeth Kleinveld,Sigrid Klotz et al.
Omar Keritam et al.
Background: Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder characterised by progressive muscle weakness and ultimately death from respiratory failure. Heterogeneity in disease trajectories and outcome...
Multicenter Study
Journal of neurology. 2026 Jan 10;273(1):74. DOI:10.1007/s00415-025-13614-y 2026
Effects of deep brain stimulation on non-motor symptoms in Parkinson's disease: insights from longitudinal studies using consistent evaluation scales [0.03%]
深脑刺激对帕金森病非运动症状的影响：使用一致评价量表的纵向研究见解
Hongyu Xu,Zhiqiang Yan,Qiong Ye et al.
Hongyu Xu et al.
Background: Deep brain stimulation (DBS) is an effective treatment for motor symptoms in Parkinson's disease (PD). However, its effects on non-motor symptoms (NMS) have been rarely assessed due to inconsistencies in evalu...
Clinical trajectories and genetic profiles of SOD1-related amyotrophic lateral sclerosis: insights from a single-center cohort in India [0.03%]
印度单中心SOD1相关肌萎缩侧索硬化队列的临床亚型和遗传特征分析
Muddasu Suhasini Keerthipriya,Ananthapadmanabha Kotambail,Madhusudhan Deekshitha et al.
Muddasu Suhasini Keerthipriya et al.
Mutations in the superoxide dismutase 1 (SOD1) gene are a predominant, genetic cause of amyotrophic lateral sclerosis (ALS). Given the marked variability in SOD1 variant prevalence and clinical manifestations across global populations, this...
Eculizumab as a rescue therapy in acute-phase aquaporin-4 (AQP4) antibody-positive neuromyelitis optica spectrum disorder [0.03%]
补体抑制剂依库珠单抗治疗视神经脊髓炎谱系病急性期患者的疗效观察
Keyi Zeng,Wei Chen,Aiyu Lin
Keyi Zeng
Eculizumab as C5 complement protein inhibitor has been approved for the maintenance treatment of neuromyelitis optica spectrum disorder (NMOSD). However, evidence regarding its efficacy in the acute phase remain limited. This study enrolled...
Duration of EEG monitoring needed to ensure a low risk of seizure recurrence in hospitalized patients [0.03%]
住院患者的视频脑电监测时长与确保低复发风险的关系研究
Parimala Velpula Krishnamurthy,Santiago Philibert-Rosas,Maxwell Rivkin et al.
Parimala Velpula Krishnamurthy et al.
Background: Continuous EEG (cEEG) monitoring is critical for detecting seizures in hospitalized patients, but optimal durations of EEG monitoring remain unclear, particularly after a seizure has been detected on monitorin...
Survival and related factors in patients with Parkinson's disease: a multicenter prospective cohort study in China [0.03%]
中国帕金森病患者的生存和相关因素：一项多中心前瞻性队列研究
Tingwei Song,Linghui Xiang,Yuan Liu et al.
Tingwei Song et al.
Parkinson's disease (PD) is the second most common neurodegenerative disease and the fastest-growing disability-causing neurological disorder worldwide. Based on the CPDR cohort from 19 clinical centers, we summarized the mortality informat...
Multicenter Study
Journal of neurology. 2026 Jan 8;273(1):69. DOI:10.1007/s00415-026-13617-3 2026
Real-world effectiveness and safety of eculizumab in AQP4-IgG-positive neuromyelitis optica spectrum disorder [0.03%]
抗AQP4抗体阳性视神经脊髓炎谱系障碍患者中依库珠单抗的疗效和安全性研究
Emine Rabia Koc,Mehmet Fatih Yetkin,Furkan Saridas et al.
Emine Rabia Koc et al.
Objective: To evaluate the real-world effectiveness and safety of eculizumab in patients with AQP4-IgG-positive neuromyelitis optica spectrum disorder (NMOSD) and to identify predictors of disability outcomes. ...
Multicenter Study
Journal of neurology. 2026 Jan 8;273(1):67. DOI:10.1007/s00415-025-13608-w 2026
Persons with epilepsy have an elevated radiosensitivity, which may be mitigated by folic acid [0.03%]
癫痫患者放射敏感性升高，可能通过叶酸缓解
Melissa Kleber,Lukas C F Kuhlmann,Anabel Knabe et al.
Melissa Kleber et al.
Introduction: Patients undergoing radiotherapy for cancer usually have several other comorbidities and are taking various medications. Both of these factors can affect the individual radiation sensitivity of normal tissue...