Valproic acid exerts specific cellular and molecular anti-inflammatory effects in post-operative conjunctiva [0.03%]
丙戊酸对术后结膜的细胞及分子抗炎效应具有特异性
Li-Fong Seet,Li Zhen Toh,Sharon N Finger et al.
Li-Fong Seet et al.
Valproic acid (VPA) is a histone deacetylase inhibitor used clinically for neurological disorders. It is also potentially useful as anti-fibrotic therapy as it reduced collagen deposition in the post-operative conjunctiva. In this study, we...
Qian-Yuan Wu,Jian Wang,Xiao Tong et al.
Qian-Yuan Wu et al.
The 24-h rhythm of behavioral and physiological processes is a typical biological phenomenon regulated by a group of circadian rhythm genes. Dysfunction of the circadian rhythm can cause a wide range of problems, such as cancer and metaboli...
Macrophage-derived CCL18 promotes osteosarcoma proliferation and migration by upregulating the expression of UCA1 [0.03%]
巨噬细胞衍生的CCL18通过上调UCA1表达促进骨肉瘤增殖和迁移
Yang Su,Yan Zhou,Yuan-Jue Sun et al.
Yang Su et al.
Osteosarcoma (OS), which is the most common primary malignant bone tumor, has a high incidence of pulmonary metastasis. CCL18 (C-C motif chemokine ligand 18), which is secreted by tumor-associated macrophages (TAMs), has been found to be in...
ALMS1 and Alström syndrome: a recessive form of metabolic, neurosensory and cardiac deficits [0.03%]
ALMS1与Alstrom综合征：一种代谢、神经感觉和心脏缺陷的常染色体隐性形式
Tom Hearn
Tom Hearn
Alström syndrome (AS) is characterised by metabolic deficits, retinal dystrophy, sensorineural hearing loss, dilated cardiomyopathy and multi-organ fibrosis. Elucidating the function of the mutated gene, ALMS1, is critical for the developm...
Identification of molecular signatures involved in radiation-induced lung fibrosis [0.03%]
与放射性肺纤维化相关的分子标志物的鉴定
Hee Jin,Ga-Young Kang,Seulgi Jeon et al.
Hee Jin et al.
In radiotherapy, radiation (IR)-induced lung fibrosis has severe and dose-limiting side effects. To elucidate the molecular effects of IR fibrosis, we examined the fibrosis process in irradiated mouse lung tissues. High focal IR (90 Gy) was...
Propionibacterium acnes induces discogenic low back pain via stimulating nucleus pulposus cells to secrete pro-algesic factor of IL-8/CINC-1 through TLR2-NF-κB p65 pathway [0.03%]
不动杆菌通过TLR2-NF-κB p65途径刺激髓核细胞分泌IL-8/CINC-1介导椎间盘源性下腰痛
Yucheng Jiao,Ye Yuan,Yazhou Lin et al.
Yucheng Jiao et al.
Latent infection of Propionibacterium acnes was considered as a new pathogeny for low back pain (LBP); however, there is no credible animal evidence or mechanism hypothesis. This study proved that P. acnes is a causative pathogen of bacteri...
C L Stothers,L Luan,B A Fensterheim et al.
C L Stothers et al.
Hematopoietic myeloblasts give rise to macrophages, dendritic cells, and neutrophils. Circulating myeloid cells detect invading microbes using pattern recognition receptors and subsequently orchestrate an innate immune response to contain a...
Antigen-presenting cell diversity for T cell reactivation in central nervous system autoimmunity [0.03%]
中枢神经系统自身免疫中T细胞活化的抗原呈递细胞多样性
Ari Waisman,Lisa Johann
Ari Waisman
Autoreactive T cells are considered the major culprits in the pathogenesis of many autoimmune diseases like multiple sclerosis (MS). Upon activation in the lymphoid organs, autoreactive T cells migrate towards the central nervous system (CN...
Pre-treatment with angiotensin-(1-7) inhibits tumor growth via autophagy by downregulating PI3K/Akt/mTOR signaling in human nasopharyngeal carcinoma xenografts [0.03%]
降压肽Angiotensin-(1-7)通过下调PI3K/Akt/mTOR信号诱导自噬抑制鼻咽癌裸鼠移植瘤的生长
Yu-Tsai Lin,Hung-Chen Wang,Hui-Ching Chuang et al.
Yu-Tsai Lin et al.
The highest incidence of nasopharyngeal carcinoma (NPC) is in southeast China, including Taiwan. Many side effects have been observed following radiation therapy with chemotherapy; hence, exploring new treatment modalities for NPC is an imp...
Hypoxia-inducible factor 1α protects peripheral sensory neurons from diabetic peripheral neuropathy by suppressing accumulation of reactive oxygen species [0.03%]
缺氧诱导因子1α通过抑制活性氧积累保护外周感觉神经元免受糖尿病外周神经病变影响
Daniel Rangel Rojas,Irmgard Tegeder,Rohini Kuner et al.
Daniel Rangel Rojas et al.
Diabetic peripheral neuropathy (DPN) is one of the most common diabetic complications. Mechanisms underlying nerve damage and sensory loss following metabolic dysfunction remain largely unclear. Recently, hyperglycemia-induced mitochondrial...