Treprostinil reduces endothelial damage in murine sinusoidal obstruction syndrome [0.03%]
曲普前列腺素能减少小鼠肝窦状障碍综合征内的内皮损伤
Madeleine Themanns,Florian Koban,Christian Bergmayr et al.
Madeleine Themanns et al.
Sinusoidal obstruction syndrome (SOS) is a major complication after hematopoietic stem cell transplantation and belongs to a group of diseases increasingly identified as transplant-related systemic endothelial disease. Administration of def...
Connexin43 hemichannel block protects against the development of diabetic retinopathy signs in a mouse model of the disease [0.03%]
缝隙连接蛋白43半通道阻断剂可防治糖尿病鼠视网膜并发症的发展恶化
Odunayo O Mugisho,Colin R Green,David M Squirrell et al.
Odunayo O Mugisho et al.
Diabetic retinopathy (DR) is a vascular disease of the neuroretina characterised by hyperglycaemia and inflammation. Current DR therapies target late-stage vascular defects and there is evidence to suggest that they contribute to geographic...
Effect of DJ-1 on the neuroprotection of astrocytes subjected to cerebral ischemia/reperfusion injury [0.03%]
Parkin和PINK1在DJ-1缺失的神经保护中的作用研究
Li Peng,Yipeng Zhao,Yixin Li et al.
Li Peng et al.
Astrocytes are involved in neuroprotection, and DJ-1 is an important antioxidant protein that is abundantly expressed in reactive astrocytes. However, the role of DJ-1 in astrocytes' neuroprotection in cerebral ischemia/reperfusion injury a...
Coexpression of FOXK1 and vimentin promotes EMT, migration, and invasion in gastric cancer cells [0.03%]
FOXPK1和波形蛋白的共表达通过上皮间质转化促进胃癌细胞迁移侵袭
Hui Zhang,Xiaosheng Wu,Yizhi Xiao et al.
Hui Zhang et al.
In human gastric cancer (GC), the upregulation of FOXK1 and vimentin is frequently observed in cancer cells and correlates with increased malignancy. We report that FOXK1 synergizes with vimentin to promote GC invasion and metastasis via th...
Interleukin-23 receptor signaling mediates cancer dormancy and radioresistance in human esophageal squamous carcinoma cells via the Wnt/Notch pathway [0.03%]
细胞因子白介素-23受体信号通过Wnt/Notch通路介导人食管鳞癌的癌细胞休眠和放疗抵抗性
Yuepeng Zhou,Yuting Su,Haitao Zhu et al.
Yuepeng Zhou et al.
In the tumor microenvironment, inflammatory cells and molecules influence almost every process; among them, interleukin-23 (IL-23) is a pro-inflammatory molecule that exhibits pro- or anti-tumor properties, but both activities remain poorly...
KIAA1199 promotes invasion and migration in non-small-cell lung cancer (NSCLC) via PI3K-Akt mediated EMT [0.03%]
KIAA1199通过PI3K-Akt介导的上皮间质转化促进非小细胞肺癌（NSCLC）的侵袭和迁移
Zhiyuan Tang,Yang Ding,Qin Shen et al.
Zhiyuan Tang et al.
KIAA1199 is often upregulated in cancer cells, including non-small-cell lung cancer (NSCLC). Although KIAA1199 is associated with aggressive tumor phenotype and poor survival in NSCLC, little is known about its functional role in NSCLC prog...
Long non-coding RNA H19 inhibition promotes hyperglycemia in mice by upregulating hepatic FoxO1 levels and promoting gluconeogenesis [0.03%]
长链非编码RNA H19抑制通过上调FoxO1水平促进小鼠高血糖和糖异生
Neha Goyal,Shweta Tiwary,Devesh Kesharwani et al.
Neha Goyal et al.
In a previous report from our laboratory, it was reported that hepatic levels of the long non-coding RNA (lncRNA), H19 are decreased in diabetic mice which elevates hepatic gluconeogenesis and glucose output. But, the mechanisms of H19 inhi...
Inhibition of YAP with siRNA prevents cartilage degradation and ameliorates osteoarthritis development [0.03%]
siRNA抑制YAP表达可防止软骨降解并改善骨关节炎病理进展
Yong Gong,Song-Jian Li,Rui Liu et al.
Yong Gong et al.
The Hippo/YAP signaling pathway is important for mediating organ size and tissue homeostasis, but its role in osteoarthritis (OA) remains unclear. We aimed to investigate the role of Hippo/YAP signaling pathway in OA development. YAP expres...
Downregulation of DAPK1 promotes the stemness of cancer stem cells and EMT process by activating ZEB1 in colorectal cancer [0.03%]
DAPK1下调通过激活ZEB1促进结直肠癌瘤干细胞的干性和上皮间质转化过程
Wenzheng Yuan,Jintong Ji,Yan Shu et al.
Wenzheng Yuan et al.
Cancer stem cells (CSCs) and epithelial-mesenchymal transition (EMT) play an important role in the metastasis and chemoresistance in the context of colorectal cancer (CRC). Downregulation of death associated protein kinase 1 (DAPK1) may pro...
Dichotomal functions of phosphorylated and unphosphorylated STAT1 in hepatocellular carcinoma [0.03%]
肝癌中磷酸化和非磷酸化的STAT1的双重功能
Buyun Ma,Kan Chen,Pengyu Liu et al.
Buyun Ma et al.
Interferons (IFNs) with antiviral and immune-stimulatory functions have been widely used in prevention and treatment of hepatocellular carcinoma (HCC). Signal transducer and activator of transcription 1 (STAT1) is a key element of the IFN s...