Insight into the mechanism of action of dimethyl fumarate in multiple sclerosis [0.03%]
马来酸二甲酯治疗多发性硬化的机制研究新见解
Sudhir Kumar Yadav,Devika Soin,Kouichi Ito et al.
Sudhir Kumar Yadav et al.
Dimethyl fumarate (DMF) is an oral, disease-modifying agent for the treatment of relapsing-remitting multiple sclerosis (RRMS). However, details regarding its mode of action are still emerging. It is believed that the mode of action of DMF ...
Improving engraftment of hepatocyte transplantation using alpha-1 antitrypsin as an immune modulator [0.03%]
利用α-1抗胰蛋白酶作为免疫调节剂改善肝细胞移植的植入率
Charlotte Lee,Anil Dhawan,Valeria Iansante et al.
Charlotte Lee et al.
For patients with non-cirrhotic liver-based metabolic disorders, hepatocyte transplantation can be an effective treatment. However, long-term function of transplanted hepatocytes following infusion has not been achieved due to insufficient ...
Metanephric mesenchyme-derived Foxd1+ mesangial precursor cells alleviate mesangial proliferative glomerulonephritis [0.03%]
肾元间质源性Foxd1阳性系膜前体细胞可缓解系膜增生性肾小球肾炎
Meiling Jin,Zhong Yin,Kai Wei et al.
Meiling Jin et al.
Mesangial proliferative glomerulonephritis (MsPGN) is a glomerular disease characterized by the proliferation of mesangial cells and the accumulation of mesangial matrix. No effective treatment is currently able to stop or reverse the disea...
Klotho recovery by genistein via promoter histone acetylation and DNA demethylation mitigates renal fibrosis in mice [0.03%]
通过启动子组蛋白乙酰化和DNA去甲基化介导的类风湿因子恢复减轻小鼠肾纤维化
Yanning Li,Fang Chen,Ai Wei et al.
Yanning Li et al.
Renal fibrosis is a common histomorphological feature of renal aging and chronic kidney diseases of all etiologies, and its initiation and progression are substantially influenced by aberrant epigenetic modifications of fibrosis-susceptible...
Mitochondrial quality control mechanisms as potential therapeutic targets in sepsis-induced multiple organ failure [0.03%]
线粒体质量控制机制可能成为防治脓毒症多器官功能障碍的治疗靶点
You Wu,Yong-Ming Yao,Zhong-Qiu Lu
You Wu
Sepsis is a dysregulated response to severe infection characterized by life-threatening organ failure and is the leading cause of mortality worldwide. Multiple organ failure is the central characteristic of sepsis and is associated with poo...
Su-Jeong Kim,Brendan Miller,Hiroshi Kumagai et al.
Su-Jeong Kim et al.
Eric W Klee,Michael T Zimmermann
Eric W Klee
Genetic variants in low-density lipoprotein receptor (LDLR) are known to cause familial hypercholesterolemia (FH), occurring in up to 1 in 200 people (Youngblom E. et al. 1993 and Nordestgaard BG et al. 34:3478-3490a, 2013) and leading to s...
Correction to: Trichostatin A, a histone deacetylase inhibitor, induces synergistic cytotoxicity with chemotherapy via suppression of Raf/MEK/ERK pathway in urothelial carcinoma [0.03%]
特拉霍斯丁A是一种组蛋白脱乙酰酶抑制剂，可通过抑制Raf/MEK/ERK途径与化疗协同诱导尿路上皮癌细胞毒性（对“Trichostatin A, a histone deacetylase inhibitor, induces synergistic cytotoxicity with chemotherapy via suppression of Raf/MEK/ERK pathway in urothelial carcinoma”的中文翻译）
Wei-Chou Lin,Fu-Shun Hsu,Kuan-Lin Kuo et al.
Wei-Chou Lin et al.
In Fig. 1b, upper part, the cell viability counts after treatment with cisplatin and TSA in T24 cells was by mistake a duplication of the image for NTUB1 on the left. In the corrected version of Fig. 1, the image was replaced appropriately.
Efficacy of novel selective NLRP3 inhibitors in human and murine retinal pigment epithelial cells [0.03%]
新型选择性NLRP3抑制剂在人和小鼠视网膜色素上皮细胞中的疗效
Luping Wang,Sarah Schmidt,Petra P Larsen et al.
Luping Wang et al.
NLRP3 inflammasome activation in the retinal pigment epithelium (RPE) is observed in atrophic age-related macular degeneration (AMD), and pharmacological NLRP3 inhibition may provide a therapeutic strategy to halt disease progression. We te...
Exploring the roles of MSCs in infections: focus on bacterial diseases [0.03%]
间充质干细胞在感染中的作用：重点关注细菌性疾病
Pasquale Marrazzo,Annunziata Nancy Crupi,Francesco Alviano et al.
Pasquale Marrazzo et al.
Despite human healthcare advances, some microorganisms continuously react evolving new survival strategies, choosing between a commensal fitness and a pathogenic attitude. Many opportunistic microbes are becoming an increasing cause of clin...