Current understanding of the immunosuppressive properties of mesenchymal stromal cells [0.03%]
关于间充质基质细胞免疫抑制特性的认识
Ligia Lins de Castro,Miquéias Lopes-Pacheco,Daniel Jay Weiss et al.
Ligia Lins de Castro et al.
Several studies have demonstrated the anti-inflammatory potential of mesenchymal stromal cells (MSCs) isolated from bone marrow, adipose tissue, placenta, and other sources. Nevertheless, MSCs may also induce immunosuppression when administ...
Lan Bai,Hongliang Li
Lan Bai
Hepatic lipid metabolism is closely associated with certain diseases, such as obesity, diabetes, fatty liver, and hepatic fibrosis. Hepatic steatosis results from systemic metabolic dysfunction that occurs via multiple processes. The initia...
Regenerative potential of adipocytes in hypertrophic scars is mediated by myofibroblast reprogramming [0.03%]
脂肪细胞在肥厚性瘢痕中的再生潜能通过肌成纤维细胞重编程介导
Katharina Hoerst,Lenie van den Broek,Christoph Sachse et al.
Katharina Hoerst et al.
Abnormal scarring is a major challenge in modern medicine. The central role of myofibroblasts and TGF-β signaling in scarring is widely accepted, but effective treatment options are missing. Autologous fat grafting is a novel approach that...
Activation of NF-κB in B cell receptor signaling through Bruton's tyrosine kinase-dependent phosphorylation of IκB-α [0.03%]
B细胞受体信号转导过程中通过Btk依赖的IκB-α磷酸化活化NF-κB
Marilena Pontoriero,Giuseppe Fiume,Eleonora Vecchio et al.
Marilena Pontoriero et al.
The antigen-mediated triggering of B cell receptor (BCR) activates the transcription factor NF-κB that regulates the expression of genes involved in B cell differentiation, proliferation, and survival. The tyrosine kinase Btk is essentiall...
Comment on "Nuclear localization of LDL receptor-related protein 1B in mammary gland carcinogenesis" [0.03%]
关于“低密度脂蛋白受体相关蛋白1B在乳腺癌发生中的核定位”的评论
Chengyu Yang,Long Zhao,Xuemei Liu et al.
Chengyu Yang et al.
Mitochondrial complex I deficiency and cardiovascular diseases: current evidence and future directions [0.03%]
线粒体复合物I缺乏与心血管疾病：当前证据及未来方向
Maurizio Forte,Silvia Palmerio,Franca Bianchi et al.
Maurizio Forte et al.
Compelling evidence demonstrates the emerging role of mitochondrial complex I deficiency in the onset and development of cardiovascular diseases (CVDs). In particular, defects in single subunits of mitochondrial complex I have been associat...
Dimethylaminomicheliolide ameliorates peritoneal fibrosis through the activation of autophagy [0.03%]
N,N-二甲氨基米雅利内酯通过激活自噬缓解腹膜纤维化
Shuting Li,Fenfen Peng,Wangqiu Gong et al.
Shuting Li et al.
Peritoneal fibrosis (PF) is a major cause of ultrafiltration failure in patients receiving long-term peritoneal dialysis (PD), and effective prevention and treatment strategies are urgently needed. The dimethylamino Michael adduct of a natu...
Jung Hwa Park,Hyun Jin Park,Sung Eun Lee et al.
Jung Hwa Park et al.
Sepsis is a disease responsible for the death of almost all critical patients. Once infected by virus or bacteria, patients can die due to systemic inflammation within a short period of time. Cytokine storm plays an essential role in causin...
Serpin B1 defect and increased apoptosis of neutrophils in Cohen syndrome neutropenia [0.03%]
Cohen综合征中性粒细胞减少症中 Serpin B1 缺陷和中性粒细胞凋亡增加
Laurence Duplomb,Julie Rivière,Gaëtan Jego et al.
Laurence Duplomb et al.
Cohen syndrome (CS) is a rare genetic disorder due to mutations in VPS13B gene. Among various clinical and biological features, CS patients suffer from inconsistent neutropenia, which is associated with recurrent but minor infections. We de...
Interleukin-26 upregulates interleukin-22 production by human CD4+ T cells in tuberculous pleurisy [0.03%]
细胞因子白介素-26通过活化CD4⁺T淋巴细胞促进白介素-22生成在肺外结核中的作用机制研究
Min Zhang,Yi-Ran Niu,Jing-Yuan Liu et al.
Min Zhang et al.
IL-26 is a potentially important player in host defense and may be a pathogenic factor in the chronic inflammatory disorders of humans. However, the involvement of IL-26 in tuberculous pleural effusion (TPE) has not been investigated. The c...