Metabolomic signature of type 1 diabetes-induced sensory loss and nerve damage in diabetic neuropathy [0.03%]
糖尿病性神经病中I型糖尿病引起的感官丧失和神经损伤的代谢标志物
Daniel Rangel Rojas,Rohini Kuner,Nitin Agarwal
Daniel Rangel Rojas
Diabetic-induced peripheral neuropathy (DPN) is a highly complex and frequent diabetic late complication, which is manifested by prolonged hyperglycemia. However, the molecular mechanisms underlying the pathophysiology of nerve damage and s...
ALIX increases protein content and protective function of iPSC-derived exosomes [0.03%]
ALIX通过增加诱导多能干细胞来源外泌体的蛋白含量从而增强其保护功能
Ruiting Sun,Yingying Liu,Meng Lu et al.
Ruiting Sun et al.
Nature of exosome-secreting cells determines exosome content and function. ALIX, involved in exosome biogenesis, promotes cell degeneration. Here, ALIX was knocked out (iPSC-ALIX-/-) and overexpressed (iPSC-ALIX3+) in induced pluripotent st...
The monocyte-dependent immune response to bacteria is suppressed in smoking-induced COPD [0.03%]
吸烟引起的慢性阻塞性肺疾病中单核细胞依赖性免疫反应受到抑制
Jürgen Knobloch,Susanne Panek,Sarah Derya Yanik et al.
Jürgen Knobloch et al.
COPD patients have an increased susceptibility to bacterial airway infections that can induce exacerbations. In response to infections, circulating monocytes become recruited to the infected tissue and secrete cytokines. We hypothesized tha...
Role of adiponectin in the metabolism of skeletal muscles in collagen VI-related myopathies [0.03%]
Ⅵ型胶原相关肌病中脂联素在骨骼肌代谢中的作用
Tania Gamberi,Francesca Magherini,Michele Mannelli et al.
Tania Gamberi et al.
The role of adiponectin has been particularly deepened in diabetic muscles while the study of adiponectin in hereditary myopathies has been marginally investigated. Here, we report the study about adiponectin effects in Col6a1-/- (collagen ...
Liangjing Zhou,Shengnan Jia,Yan Chen et al.
Liangjing Zhou et al.
Recent studies have shown that the non-enzymatic function of CD73 plays a key role in tumor progression, but this function of CD73 in pancreatic cancer cells has not been studied. Furthermore, little is known about the mechanism involved in...
Beraprost sodium mitigates renal interstitial fibrosis through repairing renal microvessels [0.03%]
贝前列素钠通过修复肾脏微血管缓解肾间质纤维化
Shulin Li,Yanping Wang,Lu Chen et al.
Shulin Li et al.
Beraprost sodium (BPS), as a prostacyclin analog, plays a significant role in various diseases based on its antiplatelet and vasodilation functions. However, its regulation and role in chronic kidney disease (CKD) still remain elusive. Here...
Double deletion of Panx1 and Panx3 affects skin and bone but not hearing [0.03%]
Panx1和Panx3的双重缺失影响皮肤和骨骼但不影响听力
J M Abitbol,B L O&#x;Donnell,C B Wakefield et al.
J M Abitbol et al.
Pannexins (Panxs), large-pore channel forming glycoproteins, are expressed in a wide variety of tissues including the skin, bone, and cochlea. To date, the use of single knock-out mouse models of both Panx1 and Panx3 have demonstrated their...
Plasma membrane-localized TMEM16 proteins are indispensable for expression of CFTR [0.03%]
TMEM16蛋白定位于质膜上，对CFTR的表达不可或缺
Roberta Benedetto,Jiraporn Ousingsawat,Inês Cabrita et al.
Roberta Benedetto et al.
The cystic fibrosis transmembrane conductance regulator (CFTR) is the secretory chloride channel in epithelial tissues that has a central role in cystic fibrosis (CF) lung and gastrointestinal disease. A recent publication demonstrates a cl...
PRSS21/testisin inhibits ovarian tumor metastasis and antagonizes proangiogenic angiopoietins ANG2 and ANGPTL4 [0.03%]
丝心蛋白抑制卵巢肿瘤转移并拮抗促血管生成血管生成素angiopoietin-2和ANGPTL4的作用
Gregory D Conway,Marguerite S Buzza,Erik W Martin et al.
Gregory D Conway et al.
Ovarian cancer is the leading cause of death among all the gynecological cancers in the USA. Ovarian cancer employs a unique mode of metastasis, as exfoliated tumor cells disseminate within the peritoneal cavity, colonizing in several sites...
Response to Yang et. al [0.03%]
对杨等人文章的评论
Yoshimi Asano,Chiemi Saigo,Yusuke Kito et al.
Yoshimi Asano et al.