A rapid, safe, and quantitative in vitro assay for measurement of uracil-DNA glycosylase activity [0.03%]
一种快速、安全且可定量的体外测定尿嘧啶-DNA糖苷酶活性的方法
Tiziana Squillaro,Mauro Finicelli,Nicola Alessio et al.
Tiziana Squillaro et al.
Base excision repair (BER) is a frontline repair mechanism that operates through the G1 phase of the cell cycle, which ensures the genome integrity by repairing thousands of DNA lesions due to endogenous and exogenous agents. Its correct fu...
Filipa M Ferreira,Pushpalatha Palle,Johannes Vom Berg et al.
Filipa M Ferreira et al.
Bone marrow chimeras are used routinely in immunology research as well as in other fields of biology. Here, we provide a concise state-of-the-art review about the types of chimerisms that can be achieved and the type of information that eac...
Regulation and role of the ER stress transcription factor CHOP in alveolar epithelial type-II cells [0.03%]
肺泡上皮II型细胞中内质网应激转录因子CHOP的调控及其作用
Oleksiy Klymenko,Martin Huehn,Jochen Wilhelm et al.
Oleksiy Klymenko et al.
Idiopathic pulmonary fibrosis (IPF) is a fatal disease characterized by type-II alveolar epithelial cell (AECII) injury and fibroblast hyperproliferation. Severe AECII endoplasmic reticulum (ER) stress is thought to underlie IPF, but is yet...
Targeted inhibition of histone deacetylase leads to suppression of Ewing sarcoma tumor growth through an unappreciated EWS-FLI1/HDAC3/HSP90 signaling axis [0.03%]
靶向抑制组蛋白去乙酰化酶通过一个未被重视的EWS-FLI1/HDAC3/HSP90信号轴来抑制尤因肉瘤肿瘤生长
Yan Ma,Michael Baltezor,Lian Rajewski et al.
Yan Ma et al.
Ewing sarcoma (ES) are aggressive pediatric bone and soft tissue tumors driven by EWS-ETS fusion oncogenes, most commonly EWS-FLI1. Treatment of ES patients consists of up to 9 months of alternating courses of 2 chemotherapeutic regimens. F...
Critical role of interleukin-23 in development of asthma promoted by cigarette smoke [0.03%]
白细胞介素-23在香烟烟雾促进哮喘发生发展中起关键作用
Hyun Seung Lee,Da-Eun Park,Ji-Won Lee et al.
Hyun Seung Lee et al.
It has been recently reported that cigarette smoke exposure during allergen sensitization facilitates the development of allergic asthma; however, the underlying mechanisms remain elusive. We evaluated the role of interleukin (IL-23) in a c...
Suman Acharya,Maheshwor Timilshina,Jae-Hoon Chang
Suman Acharya
Mevalonate is a precursor in a biosynthetic pathway that is important for the coordination of regulatory T cell (Treg) proliferation and upregulation of the suppressive function that establishes the functional competency of Tregs. The exten...
Random gene sets in predicting survival of patients with hepatocellular carcinoma [0.03%]
随机基因集合在预测肝细胞癌患者生存期中的应用
Timo Itzel,Rainer Spang,Thorsten Maass et al.
Timo Itzel et al.
Despite multiple publications, molecular signatures predicting the course of hepatocellular carcinoma (HCC) have not yet been integrated into clinical routine decision-making. Given the diversity of published signatures, optimal number, bes...
Benefits of a factorial design focusing on inclusion of female and male animals in one experiment [0.03%]
析因设计的优势：一次实验同时纳入雌雄动物的好处
Thorsten Buch,Katharina Moos,Filipa M Ferreira et al.
Thorsten Buch et al.
Disease occurrence, clinical manifestations, and outcomes differ between men and women. Yet, women and men are most of the time treated similarly, which is often based on experimental data over-representing one sex. Accounting for persistin...
Antuani Rafael Baptistella,Michele Christine Landemberger,Marcos Vinicios Salles Dias et al.
Antuani Rafael Baptistella et al.
Rectal cancer represents one third of the colorectal cancers that are diagnosed. Neoadjuvant chemoradiation is a well-established protocol for rectal cancer treatment reducing the risk of local recurrence. However, a pathologic complete res...
Circadian rhythms: a possible new player in non-alcoholic fatty liver disease pathophysiology [0.03%]
生物钟节律：非酒精性脂肪肝疾病病理生理的新的可能因素
Davide Gnocchi,Carlo Custodero,Carlo Sabbà et al.
Davide Gnocchi et al.
Over the last decades, a better knowledge of the molecular machinery supervising the regulation of circadian clocks has been achieved, and numerous findings have helped in unravelling the outstanding significance of the molecular clock for ...