Prospect and challenge of detecting dynamic gene copy number increases in stem cells by whole genome sequencing [0.03%]
通过全基因组测序检测干细胞中动态基因拷贝数增加的前景与挑战
Ulrike Fischer,Christina Backes,Tobias Fehlmann et al.
Ulrike Fischer et al.
Gene amplification is an evolutionarily well-conserved and highly efficient mechanism to increase the amount of specific proteins. In humans, gene amplification is a hallmark of cancer and has recently been found during stem cell differenti...
The median eminence as the hypothalamic area involved in rapid transfer of glucose to the brain: functional and cellular mechanisms [0.03%]
下丘脑 Median Eminence 在快速将葡萄糖转移到大脑中的作用：功能和细胞机制
Fernando Martínez,Manuel Cifuentes,Juan Carlos Tapia et al.
Fernando Martínez et al.
Our data proposes that glucose is transferred directly to the cerebrospinal fluid (CSF) of the hypothalamic ventricular cavity through a rapid "fast-track-type mechanism" that would efficiently stimulate the glucosensing areas. This mechani...
Ramasamy Paulmurugan,Meenakshi Malhotra,Tarik F Massoud
Ramasamy Paulmurugan
Non-coding ribonucleic acids (ncRNAs) are a diverse group of RNA molecules that are mostly not translated into proteins following transcription. We review the role of ncRNAs in the pathobiology of glioblastoma (GBM), and their potential app...
AMPK activation inhibits the functions of myeloid-derived suppressor cells (MDSC): impact on cancer and aging [0.03%]
AMPK激活抑制髓系源性抑制细胞(MDSC)的功能：对癌症和衰老的影响
Antero Salminen,Anu Kauppinen,Kai Kaarniranta
Antero Salminen
AMP-activated protein kinase (AMPK) has a crucial role not only in the regulation of tissue energy metabolism but it can also control immune responses through its cooperation with immune signaling pathways, thus affecting immunometabolism a...
Correction to: Critical role of interleukin-23 in development of asthma promoted by cigarette smoke [0.03%]
Correction to: 白细胞介素-23在吸烟所致哮喘发病中起关键作用
Hyun Seung Lee,Da-Eun Park,Ji-Won Lee et al.
Hyun Seung Lee et al.
The original publication of this paper contains a mistake.
Therapeutic potential of AAV9-S15D-RLC gene delivery in humanized MYL2 mouse model of HCM [0.03%]
人源化MYL2小鼠HCM模型中AAV9-S15D-RLC基因传递的治疗潜力
Sunil Yadav,Chen-Ching Yuan,Katarzyna Kazmierczak et al.
Sunil Yadav et al.
Familial hypertrophic cardiomyopathy (HCM) is an autosomal dominant disorder characterized by ventricular hypertrophy, myofibrillar disarray, and fibrosis, and is primarily caused by mutations in sarcomeric genes. With no definitive cure fo...
RPSAP52 lncRNA is overexpressed in pituitary tumors and promotes cell proliferation by acting as miRNA sponge for HMGA proteins [0.03%]
RPSAP52长链非编码RNA在垂体肿瘤中过表达并通过作用于HMGA蛋白的海绵微小核糖核酸促进细胞增殖
Daniela D&#x;Angelo,Paula Mussnich,Romina Sepe et al.
Daniela D&#x;Angelo et al.
Long non-coding RNAs (lncRNAs) are emerging as fundamental players in cancer biology. Indeed, they are deregulated in several neoplasias and have been associated with cancer progression, tumor recurrence, and resistance to treatment, thus r...
Pathological cardiac hypertrophy: the synergy of adenylyl cyclases inhibition in cardiac and immune cells during chronic catecholamine stress [0.03%]
慢性儿茶酚胺压力下心脏和免疫细胞中环鸟昔酸酶抑制的协同作用在病理性心室肥大中的作用
Gabriel Komla Adzika,Jeremiah Ong&#x;achwa Machuki,Wenkang Shang et al.
Gabriel Komla Adzika et al.
Response to stressors in our environment and daily lives is an adaptation conserved through evolution as it is beneficial in enhancing the survival and continuity of humans. Although stressors have evolved, the drastic physiological respons...
Regulation of osteoblast behaviors via cross-talk between Hippo/YAP and MAPK signaling pathway under fluoride exposure [0.03%]
氟暴露下Hippo/YAP信号通路和MAPK信号通路互作调控成骨细胞行为的研究
Wen-Qing Zhu,Ying-Juan Yu,Li-Na Xu et al.
Wen-Qing Zhu et al.
Titanium is widely used in implant materials, while excessive fluoride may have negative effects on the osseointegration between the titanium and osteoblasts. Although the underlying mechanisms are still not clear, the mitogen-activated pro...
Macrophage derived TNFα promotes hepatic reprogramming to Warburg-like metabolism [0.03%]
巨噬细胞衍生的TNFα促进肝脏向类似瓦博格效应的代谢转变
Tatyana N Tarasenko,Maxim Jestin,Shingo Matsumoto et al.
Tatyana N Tarasenko et al.
During infection, hepatocytes must undergo a reprioritization of metabolism, termed metabolic reprogramming. Hepatic metabolic reprogramming in response to infection begins within hours of infection, suggesting a mechanism closely linked to...