The role of the TIM-3 receptor in inflammatory bowel disease and autoimmunity: implications for TIM-3 and TCR crosstalk [0.03%]
TIM-3受体在炎症性肠病和自身免疫性疾病中的作用：探讨TIM-3与TCR信号串话的含义
M Gabel,A Knauss,M F Neurath et al.
M Gabel et al.
The T cell immunoglobulin and mucin-domain receptor 3 (TIM-3) is an immune checkpoint receptor with complex effects on T cell activation and tolerance. TIM-3 is expressed on the surface of T cells in close proximity to the T cell receptor (...
Glis3 as a critical regulator of Pit1-lineages and renal functions [0.03%]
Glis3是在Pitx1谱系中和肾功能中的关键调节者
Giuditta Rurale,Ilaria Gentile,Luca Persani et al.
Giuditta Rurale et al.
The Krüppel-like GLIS3 transcription factor acts as an effector on the sonic hedgehog (Shh) pathway, regulating several biological processes and the development and postnatal function of various tissues. Given the major role of Shh signali...
TIM3-mediated differentiation of IL-10-producing CD25+ B cells by expanded regulatory T cells [0.03%]
扩增的调节性T细胞介导的IL-10产生型CD25+B细胞的分化_TIM3之路
Rowa Y Alhabbab,Daniela Mastronicola,Giovanna Lombardi et al.
Rowa Y Alhabbab et al.
Cell-based immunotherapy utilizing regulatory T cells (Tregs) has recently advanced into clinical applications, demonstrating promising results in phase I/II trials to prevent transplant rejection and treat autoimmune diseases. We have comp...
The cell death regulator c-FLIPR impairs natural killer cell responses during influenza a virus infection [0.03%]
流感A病毒感染期间细胞凋亡调节因子c-FLIPR损害自然杀伤细胞的应答反应
André Carmo-Fernandes,Neda Tafrishi,Clara Bessen et al.
André Carmo-Fernandes et al.
Apoptosis, a form of programmed cell death, is crucial for keeping homeostasis during and after infections. Cellular FLICE-inhibitory protein (c-FLIP) is an inhibitor of death receptor-mediated apoptosis, of which three isoforms have been c...
Molecular insights into irisin's role in the regulation of programmed cell death: mechanisms and therapeutic potential [0.03%]
irisin调节程序性细胞死亡的分子机制及调控作用的分子机制和治疗潜力研究
Yang Yang,Helen Pullisaar,Janne Elin Reseland et al.
Yang Yang et al.
Physical activity is widely accepted for its myriad health benefits, serving as protective mechanisms against many chronic diseases. At the molecular level, exercise exerts its beneficial effects partly through the release of myokines, part...
GATA1 controls metadherin transcription to promote oxidative stress-induced podocyte injury [0.03%]
GATA1通过调控metadherin转录促进氧化应激诱导的足细胞损伤
Yihua Chen,Wenting Wu,Liyuan Zhao et al.
Yihua Chen et al.
Oxidative stress has been demonstrated to induce damage to podocytes, which play a pivotal role in the pathogenesis of chronic kidney disease (CKD). Metadherin (MTDH), an oncogene that has been extensively investigated in various malignanci...
NO/iNOS axis impact on glioma stem cells and temozolomide resistance [0.03%]
NO/iNOS轴对胶质瘤干细胞及替莫唑胺耐药的影响
Elsa Hincapié-Arias,Carolina Moughty-Cueto,Juan Manuel Zaloff-Dakoff et al.
Elsa Hincapié-Arias et al.
Glioblastoma (GB), the most aggressive brain tumor invariably recurs despite conventional treatment (surgery, chemotherapy with temozolomide (TMZ), radiotherapy), a phenomenon linked to glioma stem cells (GSC). This study demonstrates that ...
Liensinine can improve vascular remodeling in hypertension through the ferroptosis-related TLR4 inflammatory pathway [0.03%]
莲心碱通过铁死亡相关TLR4炎症通路改善高血压血管重构
Daxin Chen,Peizhi Jia,Meiling Wang et al.
Daxin Chen et al.
Vascular remodeling, which results in aortic sclerosis, is one of the main risk factors for hypertension-related cardiovascular events. In the process of early intervention and clinical improvement, the inhibition of this process is very im...
A novel peptide-compound conjugate alleviates endotoxin-induced inflammation via NF-κB/MAPK modulation [0.03%]
一种新的肽化合物共轭体通过调节NF-κB / MAPK缓解内毒素诱导的炎症反应
Youngsic Eom,Min Jeong Jeon,Jeong Hwa Lee et al.
Youngsic Eom et al.
The anti-inflammatory ability of a novel peptide-compound conjugate, 2IP5MP-CW, synthesized by fusing 2-isopropyl-5-methylphenoxy acetic acid with cysteine and tryptophan, was investigated in this study. 2IP5MP-CW markedly inhibited the gro...
KAT2A affects the inflammatory progression of lupus nephritis through multilevel regulation of cGAS [0.03%]
KAT2A通过多级调节cGAS影响狼疮性肾炎的炎症进展
Youzhou Tang,Ying Zhang,Qingtai Cao et al.
Youzhou Tang et al.
Lysine acetyltransferase 2A (KAT2A) has been reported to modulate gene expression through acetylation on specific histone lysines. Previous research has shown that continuous inflammation promotes lupus nephritis renal damage. Our previous ...