Integrated regulation of ferroptosis in prostate cancer covering mechanisms, resistance, and translational opportunities [0.03%]
前列腺癌铁死亡的整合调控：机制、耐药性和转化机遇
Zhihong Wang,Guo Chen,Zhihong Liu
Zhihong Wang
Ferroptosis, an iron dependent form of regulated cell death driven by lipid peroxidation, has emerged as a pivotal process in prostate cancer biology and therapy. This review summarizes the multifaceted regulation of ferroptosis in prostate...
Liver specific-inhibition of LPCAT3 ameliorates metabolic dysfunction-associated steatotic liver disease [0.03%]
LPCAT3肝特异性抑制改善代谢功能障碍相关性脂肪变性肝病
Vijay Kondreddy,Ramchandra Reddy Jala,Jhansi Magisetty
Vijay Kondreddy
The membrane unsaturation in the liver is associated with abnormal biosynthesis and accumulation of cholesterol and triglycerides, which is a hallmark of metabolic dysfunction-associated steatotic liver disease (MASLD). The lysophosphatidyl...
Prosaposin in CNS health and disease, metabolic stress and exercise adaptation [0.03%]
脑源性 prosaposin 在中枢神经系统健康与疾病、代谢压力和运动适应中的作用
Hash Brown Taha,Shirley Zhu,Eric Wang
Hash Brown Taha
Prosaposin (PSAP), a highly conserved lysosomal protein and precursor of saposins A-D, has emerged as a key regulator of cellular and central nervous system (CNS) homeostasis. Disrupted PSAP trafficking may lead to amyloid protein aggregati...
Heung-Seok Bae,Yong-In Kim,DongWook Kim et al.
Heung-Seok Bae et al.
Non-small cell lung cancer (NSCLC) accounts for about 80% of all lung cancer occurrences and is divided into largely Adenocarcinoma (LUAD), Squamous cell carcinoma (LUSC), and Large cell carcinoma. In this study, using RNA-seq data between ...
Bridging gaps in mitochondrial disease diagnosis: the role of advanced biomarker discovery [0.03%]
弥合线粒体疾病诊断差距：高级生物标志物发现的作用
Tendai Makwikwi,Maryke Schoonen,Izelle Smuts et al.
Tendai Makwikwi et al.
Temozolomide increases the generation of cell heterogeneity in ERK activity in glioma cells [0.03%]
替莫唑胺增加胶质瘤细胞中ERK活性的异质性产生
Karine Rech Begnini,Julia Caroline Marcolin,Luiza Cherobini Pereira et al.
Karine Rech Begnini et al.
ERK activity governs diverse cellular responses and has significant implications in cancer biology and treatment. Cellular heterogeneity is a major feature of cancer and a barrier for therapy success, allowing cancer cells to adapt and surv...
Alcohol induces sorafenib resistance in hepatocellular carcinoma: A translational study [0.03%]
酒精通过表观遗传学调控诱导肝癌细胞索拉非尼耐药的机制研究
Anoïsia Courtois,Constance Marié,Gregory Fouquet et al.
Anoïsia Courtois et al.
Alcohol is a major cause of hepatocellular carcinoma (HCC), accounting for 30% of cases worldwide. Sorafenib, a tyrosine kinase inhibitor (TKI), was the standard first-line treatment for advanced HCC until 2021, but sorafenib resistance is ...
Combined targeting poly (ADP-ribose) polymerase and receptor tyrosine kinase inhibits ovarian clear cell carcinoma progression through disrupted ribosome biogenesis [0.03%]
联合靶向多腺苷二磷酸核糖聚合酶和受体酪氨酸激酶通过破坏核糖体生物发生抑制卵巢透明细胞癌的发展
Chiao-Yun Lin,An-Shine Chao,Angel Chao et al.
Chiao-Yun Lin et al.
OCCC has extremely poor prognosis. ARID1A mutation-related chromatin remodeling errors are key molecular features of OCCC. Dysregulation of receptor tyrosine kinases-related signaling pathways is common in OCCC. Here we show that combinatio...
Identification of cryptic KMT2A-PTD and other novel fusion genes by transcriptome sequencing alters molecular risk stratification in AML-NK [0.03%]
通过转录组测序鉴定隐匿性KMT2A-PTD和其他新型融合基因可改变AML-NK的分子分层风险分类
Angeli Ambayya,Rozaimi Razali,Sarina Sulong et al.
Angeli Ambayya et al.
Acute myeloid leukaemia with normal karyotype (AML-NK) is a cytogenetically cryptic yet heterogeneous clinical subgroup that lacks structural chromosomal abnormalities. Although classified as an intermediate-risk group, AML-NK exhibits vari...
E2F7 targets S100A2 to suppress CD8+T cell activity in lung adenocarcinoma by regulating glutamine metabolism [0.03%]
E2F7通过调节谷氨酰胺代谢抑制肺癌中CD8⁺T细胞活性的目标S100A2
Xianchao Chen,Jinping Li,Qiang Zou et al.
Xianchao Chen et al.
Malignant cells within the tumor microenvironment have developed numerous strategies to resist the CD8+T cell-driven immune response. This study focuses on the mechanism of E2F7/S100A2 axis modulating CD8+T cell activity in lung adenocarcin...