Prognostic value of circulating glypican-4 in chronic heart failure [0.03%]
循环glypican-4在慢性心力衰竭中的预后价值
Nora Schwegel,Viktoria Höller,Viktoria Santner et al.
Nora Schwegel et al.
Glypican-4 (GPC-4), an endothelial cell surface protein, is released into the circulation in the context of ischemia, inflammation, neurohumoral activity, and shear stress. This study aimed to investigate the prognostic value of GPC-4 in ch...
Integrative multimodal transcriptomics identifies a cancer-associated fibroblast membrane signature for predicting prognosis and therapeutic response in pancreatic ductal adenocarcinoma [0.03%]
整合多模态转录组学识别出一种针对胰腺导管腺癌预后及治疗反应的癌症相关成纤维母细胞膜标志物
Leshi Zhuang,Wei Zhang,Jun Wu et al.
Leshi Zhuang et al.
Cancer-associated fibroblasts (CAFs) are central to the pancreatic ductal adenocarcinoma (PDAC) microenvironment, promoting tumor progression and therapeutic resistance. However, the expression landscape of CAF membrane proteins in PDAC rem...
Chronic spontaneous urticaria treatments and purinergic signaling: a therapeutic possibility [0.03%]
慢性自发性荨麻疹的治疗与嘌呤能信号：一种可能的疗法
Michelli Fontana,Júlia Leão Batista Simões,Geórgia de Carvalho Braga et al.
Michelli Fontana et al.
Urticaria is a skin lesion characterized by a central swelling area of varying sizes, usually surrounded by erythema and accompanied by itching or a burning sensation. Recurrence for at least six weeks characterizes chronic urticaria, a con...
Neutrophil-related gene expression profile is associated with future paediatric bronchiectasis exacerbations [0.03%]
中性粒细胞相关基因表达谱与未来儿童支气管扩张加重有关
Hannah E O&#x;Farrell,Vikas Goyal,Anne B Chang et al.
Hannah E O&#x;Farrell et al.
Acute respiratory exacerbations in bronchiectasis are important as they impair quality of life and are associated with accelerated lung function decline. Yet, no validated methods exist to identify children at increased risk of exacerbation...
TGF-β-induced autophagy in pulmonary artery endothelial cells associated with chronic thromboembolic pulmonary hypertension [0.03%]
转化生长因子诱导的肺动脉内皮细胞自噬与慢性血栓性肺动脉高压的关系
Ying-Ju Lai,Yen-Lin Huang,Ching-Yen Tsai et al.
Ying-Ju Lai et al.
Chronic thromboembolic pulmonary hypertension (CTEPH) is a progressive vascular disorder characterized by persistent thromboembolic obstruction and fibrotic remodeling of the pulmonary arteries. Although autophagy has been implicated in var...
Exploring a plasma proteomic biosignature associated with cardiac involvement in Fabry disease [0.03%]
探索与法布雷病心脏受累相关的血浆蛋白组生物标志物
Thi Hai Yen Nguyen,Quang Thu Nguyen,Franklin Ducatez et al.
Thi Hai Yen Nguyen et al.
Fabry disease (FD) is an X-linked lysosomal disorder caused by a deficiency in α-galactosidase A, leading to the accumulation of globotriaosylceramide (Gb3) and lysoGb3. While this accumulation was long seen as the leading cause of symptom...
Loss of miR-146a induces cardiomyocyte proliferation after myocardial infarction through targeting Kctd15 [0.03%]
miR-146a丧失通过靶向Kctd15促进心肌梗死后心肌细胞增殖
Chenrui Zhang,Xuejiao Wei,Yongqin He et al.
Chenrui Zhang et al.
Accumulating evidence strongly confirms that microRNAs (miRNAs) play a pivotal role in the development and progression of cardiovascular diseases. Specifically, miR-146a has been demonstrated to be implicated in the pathogenesis of multiple...
Exercise and CD8+ T cells: mechanisms of immune modulation in antitumor responses [0.03%]
运动和CD8+t细胞：抗肿瘤反应中免疫调节机制
Li Liu,Zhihao Deng,Ruiying Fang et al.
Li Liu et al.
CD8+ T cells are the core effector cells of antitumor immunity. However, their functionality is vulnerable to metabolic stress within the tumor microenvironment (TME), and they experience significant inhibition from immunosuppressive signal...
Tyrosine hydroxylase as a therapeutic target: insights from adrenergic nerve and TNBC cell interactions [0.03%]
多巴胺羟化酶作为治疗靶点的启示：肾上腺素能神经和三阴性乳腺癌细胞相互作用的影响
Yichen Luo,Yanhong Han,Huilong Nie et al.
Yichen Luo et al.
The sympathetic adrenergic nerves (SAN) play a significant role in the malignant transformation of breast cancer cells through the activity of norepinephrine (NE). However, the role of tyrosine hydroxylase (TH), a key enzyme of the NE synth...
Gsα deficiency in macrophages promotes tumor progression via the MAPK signaling pathway [0.03%]
巨噬细胞中Gsα缺乏通过MAPK信号途径促进肿瘤进展
Wenjiang Yan,Jingjing Yang,Siyu Tan et al.
Wenjiang Yan et al.
Under diverse stimuli in the tumor microenvironment, tumor-associated macrophages (TAMs) are susceptible to polarize toward an immunosuppressive phenotype. Reprogramming TAMs is a promising strategy for cancer immunotherapy. As a downstream...