Fibrotic microRNAs in the suppression of HSC activation and ECM deposition to facilitate the regression of hepatic fibrosis in zebrafish [0.03%]
用于抑制HSC活化和ECM沉积以促进斑马鱼肝纤维化消退的抗纤维化microRNA的研究
Yu-Heng Lai,Mu-Kuang He,Chung-Tsui Huang et al.
Yu-Heng Lai et al.
During liver injury, early pathological changes may go unnoticed, delaying the diagnosis until the disease has advanced to stages such as fibrosis, cirrhosis, or hepatocellular carcinoma. Hepatic fibrosis is a sign of long-term liver injury...
Kiesha Rice,Noora Lehtinen,Eetu Välimäki et al.
Kiesha Rice et al.
Phosphodiesterase 3 A (PDE3A) is a well-characterized enzyme that plays a crucial role in various cellular processes, including cAMP-mediated signaling, CREB-mediated induction of p21 and signaling through protein kinases A and G. PDE3A has...
The role and mechanism of TNFRSF21 in promoting necroptosis of vascular endothelial cells and inducing vascular leakage in sepsis [0.03%]
TNFRSF21在促进脓毒症血管内皮细胞坏死性凋亡和诱导血管渗漏中的作用及机制研究
Juntao Wang,Bindan Zhang,Yujia Wu et al.
Juntao Wang et al.
Vascular leakage in sepsis is critical factors in improving the prognosis of septic patients, with limited treatment options targeting underlying molecular mechanisms. Necroptosis is a form of cell death centered around the RIPK1/RIPK3/MLKL...
Correction to: Gsα deficiency in macrophages promotes tumor progression via the MAPK signaling pathway [0.03%]
GSα缺陷通过MAPK信号途径促进巨噬细胞中肿瘤进展 Correction to: GSα deficiency in macrophages promotes tumor progression via the MAPK signaling pathway
Wenjiang Yan,Jingjing Yang,Siyu Tan et al.
Wenjiang Yan et al.
Live-cell imaging reveals decreased cAMP in a PFE-associated c.1050-3C>G PTH1R cell model [0.03%]
活细胞成像揭示PFE相关PTH1R基因变异c.1050-3C>G模型细胞内cAMP水平降低
K Marnet,H Subramanian,M Wiesler et al.
K Marnet et al.
Primary failure of eruption (PFE) is a rare autosomal disorder provoked by heterozygous mutations in the parathyroid hormone receptor 1 (PTH1R) gene. PTH1R is a G protein-coupled receptor (GPCR) which regulates intracellular signaling molec...
Correction to: Diacerein improves liver fibrosis, steatosis, and atherosclerosis in ApoE knockout mice [0.03%]
Correction to：Diacerein改善ApoE基因敲除小鼠的肝纤维化、脂肪变性和动脉粥样硬化
Jie-Eun Lee,Isom Jin,Jung-Jae Lee et al.
Jie-Eun Lee et al.
GFRAL is required to mediate changes in systemic metabolism in response to mitochondrial stress in brown adipose tissue [0.03%]
褐色脂肪组织线粒体应激介导全身代谢变化需要GFRAL рецептор
Ayushi Sood,Joshua Peterson,Jayashree Jena et al.
Ayushi Sood et al.
Growth differentiation factor 15 (GDF15) is a cytokine induced in several tissues in response to stress. GDF15 suppresses food intake and increases energy expenditure via its actions on the glial-derived neurotrophic factor receptor α fami...
Kv1.3 regulates macrophage immune function through PI3K/AKT signaling pathway to alleviate metabolic dysfunction-associated steatohepatitis [0.03%]
钾通道 Kv1.3通过PI3K/AKT信号通路调节巨噬细胞的免疫功能从而缓解与代谢紊乱相关的脂肪性肝炎
Ting Ke,Wen-Jun Zhen,Xi-Xi Chen et al.
Ting Ke et al.
Background and aim: The progression of metabolic dysfunction-associated steatohepatitis (MASH) is closely linked to macrophage-mediated inflammatory responses. The role of Kv1.3, a key voltage-gated potassium channel regu...
Metformin sensitizes endometriosis to medroxyprogesterone acetate treatment through MIG-6 mediated signaling [0.03%]
二甲双胍通过MIG-6介导的信号通路增强子宫内膜异位症对醋酸甲地孕酮治疗的敏感性
Guanwen Gao,Lvfang Duan,Fanyue Zhu et al.
Guanwen Gao et al.
This study evaluates the synergistic therapeutic effect of metformin (MET) combined with medroxyprogesterone acetate (MPA) on endometriosis (EM) and investigates the involvement of the steroid receptor coactivator-1 (SRC-1) and mitogen-indu...
Impact of acute blue light irradiation on the molecular clock and markers associated with photoaging in skin cell models [0.03%]
急性蓝光照射对皮肤细胞模型中分子钟及光老化相关标志物的影响
Agnia Vibriani,Xinyue Chen,Susumu Kajiwara et al.
Agnia Vibriani et al.
The increased reliance on digital devices in our daily lives has exposed humans to intense levels of high-energy blue light. However, the harmful effects of blue light irradiation on human skin are less understood than UV irradiation. Notab...