MEK inhibitor cobimetinib increases calreticulin and induces immune modulation in TNBC [0.03%]
MEK抑制剂cobimetinib通过增加细胞 reticulum蛋白calreticulin诱导三阴性乳腺癌的免疫原性转化
Ling-Ming Tseng,Ka-Yi Lau,Ji-Lin Chen et al.
Ling-Ming Tseng et al.
Immunogenic cell death (ICD) can activate immune cells and potentiate the response to immunotherapy. The mitogen-activated protein kinase (MAPK) signaling pathway regulates the immune response and mediates T-cell receptor signaling. Activat...
Vasoactive intestinal peptide advances chondrogenesis and modulates pathogenic mediators in human osteoarthritis [0.03%]
血管活性肠肽促进人骨关节炎软骨细胞的软骨分化并调节致病介质
Karolina Tecza,Cristina Rodríguez-Hernández,Raúl Villanueva-Romero et al.
Karolina Tecza et al.
Current therapies for osteoarthritis (OA) focus on symptom management, rather than halting disease progression. Vasoactive intestinal peptide (VIP) has shown promising effects in musculoskeletal diseases, preserving joint integrity and modu...
Role of PANoptosis in intestinal diseases and its therapeutic implications [0.03%]
PANoptosis在肠道疾病中的作用及其治疗意义
Can Yu,Yihang Huang,Bohao Han et al.
Can Yu et al.
PANoptosis is a novel programmed inflammatory cell death pathway. It integrates pyroptosis, apoptosis, and necroptosis components via a unified molecular platform termed PANoptosome. Unlike single classical cell death pathway, PANoptosis is...
A proteomic atlas phenotyping Fabry disease identifies a precise cardiovascular risk signature that integrates mitochondrial and lysosomal pathways [0.03%]
基于蛋白质组定位的法布雷病表型分析鉴定出一个精确的心血管风险标志，它将线粒体途径和溶酶体途径整合在一起
Gaetano Santulli,Shivangi Pande,Fahimeh Varzideh
Gaetano Santulli
Fabry disease is an X-linked lysosomal storage disorder caused by α-galactosidase A deficiency, leading to progressive accumulation of Gb3 and lyso-Gb3 and a complex multisystem phenotype extending beyond substrate storage. Cardiovascular ...
The mechanism of the JNK signaling pathway in drug addiction : Author list [0.03%]
JNK信号转导通路在药物成瘾中的作用机制:作者名单
Shuang Han,Hongming Ye,Min Li et al.
Shuang Han et al.
Drug addiction is a multifactorial neurofunctional disorder influenced by a complex interplay of environmental, biological, and genetic factors. Recent studies have demonstrated that aberrant activation of the c-Jun N-terminal kinase (JNK) ...
Melatonin protects liver and periodontal tissues from inflammation exacerbated by metabolic syndrome-periodontitis association [0.03%]
褪黑素通过保护代谢综合征牙周炎加重的肝和牙周组织来发挥抗氧化作用
Ana Paula Vázquez Mosquera,Facundo Mateo Martín,Graciela Del Valle Castillo et al.
Ana Paula Vázquez Mosquera et al.
Metabolic syndrome (MetS) and periodontal disease (PD) are prevalent inflammatory conditions with global health implications. Their bidirectional interaction amplifies systemic and metabolic inflammation, worsening periodontal destruction w...
Platelet-neutrophil niches associate with epidermal immune activation and systemic inflammation in psoriatic disease [0.03%]
银屑病中血小板-中性粒细胞结合与表皮免疫活化和全身炎症的关系
Caio Santos Bonilha
Caio Santos Bonilha
Platelets are increasingly recognised as inflammatory mediators that influence leukocyte behaviour, yet their spatial organisation and contribution to psoriatic skin inflammation remain incompletely understood. Here, spatial transcriptomics...
Nuclear factor IX promotes endometriosis progression through transcriptional activation of tetraspanin-2 [0.03%]
NFIX通过转录激活四跨膜蛋白-2促进子宫内膜异位症进展
Yuqi Liu,Qing Xue,Jingwen Zhu et al.
Yuqi Liu et al.
Endometriosis is a benign yet aggressive disease characterized by enhanced proliferation and invasion of ectopic endometrial tissue. Identifying upstream regulators that co-regulate these processes will provide novel insights into endometri...
Molecular and statistical weaknesses of the p-tau217/Aβ1-42 plasma ratio for alzheimer's diagnosis [0.03%]
p-tau217/Aβ1-42血浆比值诊断阿尔茨海默病的分子和统计学局限性
Christian Griñán Ferré,Mercè Pallàs,Rafael Franco
Christian Griñán Ferré
The FDA's approval of the Lumipulse G p-tau217/Aβ1-42 plasma ratio enhances access to Alzheimer's diagnostics but risks confusing convenience with biological accuracy. The assay is scalable and non-invasive, yet it relies on a ratio of two...
Correction to: Spil mediated sEH overexpression contributes to the senescence of alveolar epithelial cells during pulmonary fibrosis in mice [0.03%]
Correction to：肺纤维化小鼠肺泡上皮细胞衰老中由Spil介导的sEH过度表达的作用
Chen-Yu Zhang,Wen-Jing Zhong,Jin-Tong Yang et al.
Chen-Yu Zhang et al.