Preclinical evaluation of cysteine protease-inhibitor aloxistatin (E64d) for heart failure therapy [0.03%]
心力衰竭治疗的半胱氨酸蛋白酶抑制剂Aloxistatin(E64d)的药理评估
Maria Jordan,Angelika Stucki-Koch,Maximilian Schinke et al.
Maria Jordan et al.
Heart failure (HF) affects over 64 million people worldwide causally linked to fibrotic scarring. None of the available cardiac drugs target fibrosis directly, underlining unmet clinical need for novel therapies. This study aimed to explore...
Zinc-binding protein metallothionein 3 protects vascular smooth muscle cells from ferroptosis via blocking lysosomal degradation of GPX4 [0.03%]
锌结合蛋白金属硫蛋白3通过阻止GPX4溶酶体降解来保护血管平滑肌细胞免受铁死亡损伤
Wenxin Lin,Xin Feng,Jingjie Chen et al.
Wenxin Lin et al.
Aortic dissection (AD) is a life-threatening vascular emergency characterized by medial degeneration and vascular smooth muscle cell (VSMC) loss. Although disruption of zinc homeostasis has been reported in patients with AD, how zinc ions a...
Clinical utility of cerebrospinal fluid interleukin-10 in central nervous system lymphoma: a molecular neuropathology-informed diagnostic meta-analysis [0.03%]
中枢神经系统淋巴瘤脑脊液中IL-10的诊断价值：基于分子神经病理学的meta分析研究
Farnoosh Aalami,Alireza Mobasheri,Ali Shahriari et al.
Farnoosh Aalami et al.
Accurate diagnosis of central nervous system lymphoma (CNSL) remains challenging, and cerebrospinal fluid (CSF) interleukin-10 (IL-10) has emerged as a promising minimally invasive biomarker. We conducted a PRISMA-DTA systematic review and ...
Molecular regulation of PGC-1α: from protein-protein interactions and post-translational modifications to pharmacological modulation [0.03%]
PGC-1α的分子调节：从蛋白质互作和翻译后修饰到药物干预
William Q Rios,Carlos M Silva,Rita Ferreira et al.
William Q Rios et al.
Peroxisome proliferator-activated receptor gamma coactivator 1α (PGC-1α) is a master transcriptional coactivator responsible for regulating cellular energy metabolism and mitochondrial biogenesis across high-energy tissues such as the hea...
Molecular determinants of thromboinflammatory activation in inflammatory bowel disease [0.03%]
炎症性肠病中促血栓炎性激活的分子决定因素
Roko Šantić,Nikola Pavlović,Marko Kumrić et al.
Roko Šantić et al.
Inflammatory bowel disease (IBD) is consistently associated with an increased risk of venous thromboembolism, particularly during active disease and hospitalization, yet thrombosis in this context extends beyond a transient inflammatory com...
Oleanolic acid modulates neuronal regeneration through KLF5-mediated FGF13 mRNA degradation to alleviate Alzheimer's disease-like cognitive dysfunction [0.03%]
oleanolic酸通过KLF5介导的FGF13 mRNA降解调节神经元再生从而缓解阿尔茨海默病样认知障碍
Dan Ren,Jiangxi Xu,Lan Xiao et al.
Dan Ren et al.
Despite understanding the pathophysiology of Alzheimer's disease (AD), the mechanisms of neuronal regeneration mediated by oleanolic acid (OA) through m6A RNA methylation remain unexplored, forming the crux of this study. In a streptozotoci...
Lentiviral GLP-1 gene therapy elicits developmental stage-dependent β-cell regeneration in diabetic rats [0.03%]
慢病毒GLP-1基因治疗可诱导糖尿病大鼠β细胞再生且与发育阶段相关
Ezgi Erbasan,Melike Aliciaslan,Fulya Erendor et al.
Ezgi Erbasan et al.
Pancreatic β-cell differentiation and regenerative capacity differ markedly between developmental stages, with the neonatal pancreas exhibiting high plasticity that enables ongoing progenitor- and ductal-derived β-cell formation, whereas ...
High mobility group motif proteins' role in fibrosis, inflammation, and vascular injury in systemic sclerosis [0.03%]
系统性硬化症中高迁移率族基序蛋白在纤维化、炎症和血管损伤中的作用
Fabian A Mendoza,Sonsoles Piera-Velazquez,Sergio A Jimenez
Fabian A Mendoza
Systemic Sclerosis (SSc) is an idiopathic systemic autoimmune disease characterized by progressive cutaneous and systemic fibrosis, severe vasculopathy, and multiple humoral and cellular immunological alterations. The pathogenesis of SSc is...
Correction to: a novel tsRNA, tRF-33-6978WPRLXN4V0O inhibits breast cancer development via regulating PTEN/AKT pathway in BHLHA15 mediated manner [0.03%]
Correction to: 通过BHLHA15介导的方式调节PTEN/AKT途径从而抑制乳腺癌发展的新型tsRNA tRF-33-6978WPRLXN4V0O
Ji Dai,Haoqiang Ji,Huihui Bai et al.
Ji Dai et al.
SIRT1 regulates CaOx crystal-induced exacerbation of renal mitochondrial dysfunction and fibrosis through PPAR-α in aged mice [0.03%]
SIRT1通过PPAR-α调节SIRT1调控CaOx晶体诱导的肾线粒体功能障碍和老化小鼠的纤维化加重
Yuexian Xu,Kaiguo Xia,Xike Mao et al.
Yuexian Xu et al.
The present study investigates how Sirtuin 1 (SIRT1) regulates the worsening of calcium oxalate (CaOx) crystal-induced mitochondrial dysfunction and fibrosis in the kidneys with age. To establish a CaOx crystal deposition model, glyoxylic a...