Adipose-derived mesenchymal stem cells for the prevention of capsular contracture [0.03%]
脂肪源性间充质干细胞预防包膜挛缩的研究进展及应用前景
Orel Govrin-Yehudain,Yasmin Korzets,Yosef Zkika et al.
Orel Govrin-Yehudain et al.
Capsular contracture (CC) is the most common complication associated with implant-based breast surgery, with particularly high risk in patients undergoing alloplastic reconstruction surgery followed by radiation therapy. Revision surgery, t...
Nociceptor neuron: a novel component directly orchestrates gastric cancer progression [0.03%]
伤害性感受器神经元：通过直接调控胃癌进展的新机制
Xiaoyu Wang,Yu Cheng,Yongjie Wang
Xiaoyu Wang
A novel tsRNA, tRF-33-6978WPRLXN4V0O inhibits breast cancer development via regulating PTEN/AKT pathway in BHLHA15-mediated manner [0.03%]
一种新的tsRNA tRF-33-6978WPRLXN4V0O通过BHLHA15介导调节PTEN / AKT通路抑制乳腺癌的发展
Ji Dai,Haoqiang Ji,Huihui Bai et al.
Ji Dai et al.
Transfer RNA-derived fragments (tRFs) are a novel class of small non-coding RNAs. Recent studies have identified diverse tRNA-derived fragments (tRFs) in various diseases, confirming their distinct roles in transcriptional and post-transcri...
Relationship between CXCR4 and GNG4 in the Brain and Chronic Stress-Induced Atherosclerosis [0.03%]
CXCR4和GNG4在慢性应激诱导的动脉粥样硬化中的脑心对话关系研究
Qianwen Wang,Lingbing Meng,Ruofan Xu et al.
Qianwen Wang et al.
Chronic stress (CS) is recognized as a contributing factor to the progression of atherosclerosis (AS), but the molecular mechanisms within the central nervous system (CNS) remain poorly understood. In this study, we established mouse models...
GraphCellNet: A deep learning method for integrated single-cell and spatial transcriptomic analysis with applications in development and disease [0.03%]
图(Graph)细胞(Cell)网络(Neb):一种深度学习方法，用于集成单细胞和空间转录组分析及其在发育和疾病中的应用
Ruoyan Dai,Zhenghui Wang,Zhiwei Zhang et al.
Ruoyan Dai et al.
Spatial transcriptomics (ST) integrates gene expression with spatial location, enabling precise mapping of cellular distributions and interactions within tissues, and is a key tool for understanding tissue structure and function. Single-cel...
IQGAP1 participates in bone marrow-derived macrophage recruitment and involves in liver inflammation/fibrosis [0.03%]
IQGAP1参与骨髓源性巨噬细胞募集并涉及肝炎/纤维化
Na Chang,Yuehan Ma,Jing Liu et al.
Na Chang et al.
IQ motif containing GTPase activating protein 1 (IQGAP1), a scaffold protein, is implicated in cell migration. Our previous studies demonstrate that sphingosine 1-phosphate (S1P) induces bone marrow-derived macrophages (BMDMs) recruitment a...
CD8 + T Cells in Gastrointestinal Cancer: a Perspective on Targeting MicroRNA [0.03%]
胃肠道癌症中的CD8+T细胞：针对MicroRNA的治疗展望
Zihan Yuan,Wei He,Wenjia Luo et al.
Zihan Yuan et al.
Gastrointestinal cancer, which is highly prevalent globally, constitutes a major threat to human health and life. The discovery of PD-L1/PD-1 has revolutionized immunotherapy, which has led to a shift in attention toward the antitumor funct...
Sex hormone-binding globulin restrains hepatic fibrosis via inhibition of Tgfβ expression [0.03%]
性激素结合球蛋白通过抑制Tgfβ的表达来限制肝纤维化
Sang R Lee,Moeka Mukae,Eui-Ju Hong
Sang R Lee
Despite the advances in the development of therapeutic strategies for liver cirrhosis, finding novel molecular targets for drug discovery is still needed to broaden clinically available options. Sex hormone-binding globulin (SHBG) is an abu...
Shujing Li,Xiaomin Yu,Lei Liang et al.
Shujing Li et al.
Tumor metastasis remains a leading cause of mortality in cancer patients. The epithelial-mesenchymal transition (EMT) is pivotal for the invasion and metastasis of cancer cells, facilitating the transformation from epithelial to mesenchymal...
Shuhong Zhao,Dan Huang,Rong Huang et al.
Shuhong Zhao et al.
The C1q/TNF-related protein family (CTRPs), a group of adipokines sharing structural homology with adiponectin (APN), have emerged as crucial regulators of metabolic and cardiovascular homeostasis. As secreted proteins with pleiotropic func...