4-Hydroxychalcone alleviated Angiotensin II-induced atrial fibrillation via immunoproteasome-IKK-NF-κB signaling pathway modulation [0.03%]
4-羟基查尔酮通过调节免疫蛋白酶体-IKK-NF-κB信号通路缓解血管紧张素II诱导的房颤
Yun-Long Zhang,Ze-Yan Xu,Yan Sun et al.
Yun-Long Zhang et al.
Atrial Fibrillation (AF) is the most common type of cardiac arrhythmia and a significant contributor to stroke occurrence. Although 4-Hydroxychalcone (4HCH) has notable anti-inflammatory and antioxidant properties, playing critical therapeu...
Decipherment of disulfidptosis-related mutation profile, chemosensitivity, and prognosis in diffuse large B-cell lymphoma [0.03%]
弥漫性大B细胞淋巴瘤中二硫化物中毒相关突变谱、化疗敏感性和预后的解析
Juanjuan Shang,Bingyu Liu,Xiaoli Zhou et al.
Juanjuan Shang et al.
Diffuse large B-cell lymphoma (DLBCL) is the most common subtype of non-Hodgkin lymphoma, of which 35-40% suffers recurrence after standard chemotherapy treatment. Disulfidptosis is a novel mode of cell death, which has been found to be ass...
Pathological noise exposure results in elevated levels of extracellular vesicles enriched with Hsp70 in the plasma [0.03%]
病理噪声暴露可导致血浆中富含Hsp70的外泌体水平升高
Wan-Yi Huang,Qin Xiong,Ying Yi et al.
Wan-Yi Huang et al.
Noise-induced hearing loss (NIHL) significantly impacts the quality of life for patients. Extracellular vesicles (EVs) play crucial roles in cellular communication, but it is unclear if the inner ear releases EVs into peripheral circulation...
Ferroptosis and iron metabolism drive fibroblast activation in silicosis: insights from a novel 3D lung matrix model [0.03%]
铁死亡和铁代谢驱动硅肺成纤维细胞活化：来自新型三维肺基质模型的见解
Chenzhao Song,Xinying Zeng,Jiaxin Wang et al.
Chenzhao Song et al.
Background: Silicosis is a lung disease marked by fibrosis and nodule formation, yet the impact of iron metabolism on these processes remains unclear. Existing models lack the ability to replicate the microenvironmental c...
Targeting mutated KRAS by HLA-A*02:01 restricted anti-KRAS TCR-mimic CAR and bispecific T cell engager [0.03%]
利用抗KRAS TCR模拟CAR和双特异性T细胞衔接器靶向突变的KRAS
Saber Ebrahimi,Benedikt J Lohnes,Shamsul A Khan et al.
Saber Ebrahimi et al.
Mutations in the KRAS proto-oncogene, particularly at codon 12, are among the most frequent genetic alterations in various cancers, and KRASG12V accounts for about 25% of all KRAS mutations observed in lung, pancreatic, and colorectal adeno...
Oral supplementation of melatonin attenuates the onset of alcohol-related liver disease [0.03%]
口服补充褪黑素可延缓酒精相关性肝病的发病
Franziska Kromm,Anja Baumann,Victor Sánchez et al.
Franziska Kromm et al.
Studies suggest that supplementing melatonin in pharmacological doses may attenuate the development of liver diseases including alcohol-related liver diseases (ALD) in model organisms. If melatonin at "physiological" doses achievable throug...
POFUT1 as a cancer biomarker: insights into its oncogenic mechanisms and clinical relevance [0.03%]
POFUT1作为癌症生物标志物的潜力：其致癌机制和临床意义的见解
Oumaima Mazour,Sébastien Legardinier,Bouabid Badaoui et al.
Oumaima Mazour et al.
Over the past decade, increasing evidence has linked the dysregulation of human protein O-fucosyltransferase 1 (POFUT1), overwhelmingly through gene overexpression, to tumor progression in multiple cancers, including colorectal, breast, gas...
Cardiovascular risk of gender-affirming estrogen therapy in a transgender rat model [0.03%]
性别确认雌激素治疗的心血管风险——转基因大鼠模型中的研究
D S Escudero,V R Martínez,Y Pirosanto et al.
D S Escudero et al.
The purpose of this study was to investigate the poorly understood cardiovascular effects of estrogen therapy (ET) in a transgender female (TGF) rat model of hypertension. This study provides novel insights into the potential risks and bene...
Whole genome DNA methylation profiles define Meniere's disease subclusters [0.03%]
整个基因组DNA甲基化谱型可定义美尼尔氏病亚群簇
Vibha Patil,Pablo Cruz-Granados,Francisca E Cara et al.
Vibha Patil et al.
Meniere disease (MD) is a cochleo-vestibular syndrome defined by episodes of vertigo associated with tinnitus and sensorineural hearing loss. While MD immune response has been linked to autoinflammation and type 2 cytokines, other molecular...
Ivan Tesakov,Anna D Korneichuk,Aleksandra A Filkova et al.
Ivan Tesakov et al.
Metastasis, a major complication in cancer, is known to depend on the interaction of tumor cells with platelets. However, anti-platelet therapy does not reliably increase survival rates. To address this, here we use light transmission aggre...