Involvement of ferroptosis in metabolic dysfunction-associated steatohepatitis-related liver diseases [0.03%]
铁死亡在代谢功能障碍相关性非酒精性脂肪性肝炎中的作用
Yiran Liu,Mingyu Zhang,Yujie Huang et al.
Yiran Liu et al.
Metabolic dysfunction-associated steatotic liver disease (MASLD), as a metabolic liver disease, is emerging as the most prevalent chronic liver disease worldwide. Metabolic dysfunction-associated steatohepatitis (MASH) is the severe form of...
Leucine-rich α-2 glycoprotein 1 is associated with increased mortality risk in patients with peripheral artery disease [0.03%]
富含亮氨酸的α-2甘露糖蛋白1与外周动脉疾病患者死亡风险增加有关
Axel Muendlein,Andreas Leiherer,Eva Maria Brandtner et al.
Axel Muendlein et al.
Leucine-rich α-2 glycoprotein 1 (LRG1) is a pro-inflammatory protein involved in pathogenic neovascularization and is considered a predictor of poor clinical outcomes in specific patient populations. The prospective value of LRG1 for predi...
Nintedanib reduces severity of post-traumatic joint contracture by modulating fibrosis and inflammation [0.03%]
尼替尼布通过调节纤维化和炎症来减轻创伤后关节挛缩的严重程度
Erik Wegner,Dennis Warnke,Victoria Buschmann et al.
Erik Wegner et al.
This study investigates the potential of nintedanib, a tyrosine kinase inhibitor with antifibrotic and anti-inflammatory properties, to mitigate post-traumatic joint contracture (PTJC) in a rat model. Given the lack of effective pharmacolog...
Unproductive alternative splicing of ATM exon 7: mapping of critical regulatory elements and identification of 34 spliceogenic variants [0.03%]
ATM外显子7不产生成熟mRNA的可变剪接：关键调控元件定位及鉴定34种新型致病性变异
Inés Llinares-Burguet,Lara Sanoguera-Miralles,Alicia García-Álvarez et al.
Inés Llinares-Burguet et al.
ATM loss-of-function variants are significantly associated with increased breast cancer risk. ATM exon 7 skipping (△(E7)) is a naturally-occurring alternative splicing event, which introduces a premature termination codon and represents a ...
Genetic deficiency of CCL5 exhibits the phenotypes of HFpEF and aggravates apoptotic cardiomyopathy in HFD-induced diabetic mice [0.03%]
遗传性CCL5缺乏表现出HFpEF表型并加重高脂饮食诱导的糖尿病小鼠凋亡心肌病
Jiung-Pang Huang,Kuan-Hsing Chen,Po-Shiuan Hsieh et al.
Jiung-Pang Huang et al.
The chemokine C-C motif ligand 5 (CCL5) has been implicated in both metabolic dysfunction and cardiovascular diseases; however, its specific role in the pathophysiology of diabetic cardiomyopathy and heart failure remains incompletely under...
Clarisse Billon,Gilles Millat,Adeline Goudal et al.
Clarisse Billon et al.
PRDM16 has been identified as a potential causal gene for cardiomyopathies, supported by reports of several cases associated with loss-of-function (LoF) variants in PRDM16. In this multi-centric study, we present the largest cohort to date ...
Rewriting the vascular script: epigenetic modifiers as scribes of metabolic reprogramming in pulmonary hypertension [0.03%]
血管重构：表观遗传修饰剂在肺动脉高压代谢重编中的作用
Runxiu Zheng,Junlan Tan,Xianya Cao et al.
Runxiu Zheng et al.
Pulmonary hypertension (PH) is a life-threatening cardiovascular condition marked by the remodeling of pulmonary vasculature. Existing treatments provide limited efficacy, emphasizing the urgent need for deeper scientific exploration. This ...
Application of mesenchymal stem cells in ferroptosis-related diseases [0.03%]
间充质干细胞在铁死亡相关疾病中的应用研究进展
Xianmei Zhong,Xue Zhang,Yuxuan Zhu et al.
Xianmei Zhong et al.
Modern medicine has achieved groundbreaking advancements in disease diagnosis and treatment, yet significant challenges remain in managing conditions such as age-related diseases, tumors, autoimmune disorders, and neurological conditions. C...
Correction to: The molecular landscape of glioblastoma-associated epilepsy [0.03%]
Correction to：胶质母细胞瘤相关癫痫的分子图谱
Thamiris Becker Scheffel,Fernando Mendonça Diz,Andréa Wieck et al.
Thamiris Becker Scheffel et al.
Published Erratum
Journal of molecular medicine (Berlin, Germany). 2025 Aug 29. DOI:10.1007/s00109-025-02590-5 2025
Discoidin, CUB and LCCL domain containing 2 modulates angiogenesis by inhibiting VEGF receptor 2 endocytosis in endothelial cells [0.03%]
盘状结构域、CUB和LCCL结构结构域2通过抑制血管内皮生长因子受体2在血管内皮细胞中的内吞作用来调节新生血管的形成
Xiaoning Liu,Shuai Wang,Qi Feng et al.
Xiaoning Liu et al.
The internalization of vascular endothelial growth factor receptor-2 (VEGFR-2) occurs in response to VEGF treatment, and it is eventually transported to the plasma membrane by several endosomes such as Rab5 and Rab11, which are responsible ...