Targeted metabolomics reveals tricarboxylic acid cycle-related metabolites serve as predictive biomarkers for trastuzumab resistance in human epidermal growth factor receptor 2-positive breast cancer [0.03%]
靶向代谢组学揭示三羧酸循环相关代谢物可作为人表皮生长因子受体乳腺癌曲妥珠单抗耐药的预测标志物
Ting Yang,Bangbang Wei,Min Wang et al.
Ting Yang et al.
Trastuzumab, a monoclonal antibody against human epidermal growth factor receptor 2 (HER2), has been proven to be effective in enhancing overall survival in patients with HER2-positive breast cancer. However, some patients exhibit resistanc...
The diagnostic and prognostic potential of extracellular vesicles as biomarkers for thyroid cancer: a systematic review [0.03%]
外泌体作为甲状腺癌生物标志物的诊断和预后价值：系统评价
Nada Mabrouk Ahmed,Kevin Beatson,Jigisha Patel et al.
Nada Mabrouk Ahmed et al.
The incidence of thyroid cancer, the most common endocrine malignancy, has increased by 313% in the past four decades and is now the seventh most common cancer worldwide. There is an urgent need for non-invasive diagnostic, prognostic, and ...
Peptide-based inhibition of CD44v6 renders liver carcinomas more susceptible to therapeutic intervention [0.03%]
基于肽的CD44v6抑制使肝癌更容易接受治疗干预
Akshaya Srikanth,Ranjitha Vishnu Anand Rao,Rui Dong et al.
Akshaya Srikanth et al.
Cluster of differentiation 44 variant 6 (CD44v6) has been described in various types of cancer, including liver cancer. Despite significant advancements in cancer therapy, there is still an urgent medical need for new therapeutic strategies...
Suppression of OTUD4 protects against myocardial ischemia-reperfusion injury by increasing autophagic flux and inhibiting apoptosis in cardiomyocytes [0.03%]
抑制OTUD4通过增加自噬流量和抑制心肌细胞凋亡来防治心肌缺血再灌注损伤
Xin-Xin Sun,Lin Qi,Ming-Jun Dai et al.
Xin-Xin Sun et al.
Dysregulated autophagic flux plays a critical role in myocardial ischemia-reperfusion injury (MIRI), complicating cardiac reperfusion therapy. In this study, we identified OTUD4 as a potential regulator of autophagic flux in MIRI using CRIS...
Neuroanatomical characterization of the cell adhesion molecule IgSF9b reveals localization to inhibitory and excitatory synapses in the mouse limbic system [0.03%]
IgSF9b细胞粘附分子的神经解剖学特征表明其在小鼠边缘系统抑制性突触和兴奋性突触中的定位
Federico Rotondo,Heba Ali,Maxim Maichle et al.
Federico Rotondo et al.
Immunoglobulin superfamily member 9b (IgSF9b) is a cell adhesion protein that has been linked to the etiology of several neuropsychiatric disorders, most notably schizophrenia and major depression. Based on previous studies in cultures, IgS...
BMSCs-derived exosomal AKAP12 alleviates neuronal cell ferroptosis by inhibiting the STAT3 and ERK signaling pathways in spinal cord injury [0.03%]
脊髓损伤中骨髓间充质干细胞源性外泌体AKAP12通过抑制STAT3和ERK信号通路缓解神经元细胞铁死亡
Fan Wang,Zhigang Pan,Hanlin Zheng et al.
Fan Wang et al.
Spinal cord injury (SCI) is a kind of central nervous system damage that causes significant disability. Although bone marrow stromal cells (BMSCs) have been shown to be an effective therapy for SCI, the regulation mechanism of BMSCs in SCI ...
Hyperbaric oxygen treatment mitigates gut dysbiosis of mice with spinal cord injury [0.03%]
高压氧治疗可改善脊髓损伤小鼠的肠道菌群失调现象
Mo Liu,Lu Yang,Ding Nan et al.
Mo Liu et al.
Gut dysbiosis impacts the recovery of neurological function after spinal cord injury (SCI). Hyperbaric oxygen (HBO) can alleviate SCI, but its effects on the gut microbiota post-SCI remain unclear. This study aimed to clarify the impact of ...
Transcriptome profiling of human dermal MDPL fibroblasts reveals a characteristic molecular signature providing insights into pathogenic mechanisms [0.03%]
人皮肤MDPL成纤维细胞转录组特征分析揭示了独特的分子标志并提供了潜在的发病机制研究见解
Michela Murdocca,Gerardo Pepe,Serena Maccaroni et al.
Michela Murdocca et al.
The emerging perception that the mammalian dermis encloses fibroblasts with differing functional identities has profound implications for understanding a wide range of genetic pathological states, including aging. MDPL syndrome (mandibular ...
Tianxiang Yang,Heping Xu
Tianxiang Yang
Pathological fibrosis is a chronic process characterized by excessive deposition of extracellular matrix (ECM), which disrupts tissue architecture and function and accelerates disease progression in organs such as the lungs, liver, heart, k...
SUV39H1 regulates progression of pediatric diffuse high-grade gliomas through modulation of β-catenin/TCF4 levels [0.03%]
SUV39H1通过调节β-连环蛋白/TCF4水平促进儿童弥漫性高级别胶质瘤进展
Alexia Klonou,Angeliki-Ioanna Giannopoulou,Christos Adamopoulos et al.
Alexia Klonou et al.
Pediatric diffuse high-grade gliomas (pHGGs) are heterogeneous and infiltrative tumors with poor prognosis. Recent molecular characterization of pHGGs has revealed an altered epigenetic profile with aberrant post-translational modifications...