Thymus-derived Foxp3+ regulatory T cells upregulate RORγt expression under inflammatory conditions [0.03%]
在炎症条件下，胸腺来源的Foxp3+调节性T细胞能上调RORγt表达
Juhao Yang,Mangge Zou,Joern Pezoldt et al.
Juhao Yang et al.
Foxp3+ regulatory T cells (Tregs) co-expressing the Th17-lineage specification factor RORγt represent a unique Treg subpopulation that has been reported to be induced upon response to gut microbiota within the intestinal immune system. Hen...
Genomics and response to long-term oxygen therapy in chronic obstructive pulmonary disease [0.03%]
基因组学与慢性阻塞性肺疾病长期氧疗反应的关系
Minseok Seo,Weiliang Qiu,William Bailey et al.
Minseok Seo et al.
Chronic obstructive pulmonary disease (COPD) is a leading cause of death worldwide, and long-term oxygen therapy has been shown to reduce mortality in COPD patients with severe hypoxemia. However, the Long-term Oxygen Treatment Trial (LOTT)...
Randomized Controlled Trial
Journal of molecular medicine (Berlin, Germany). 2018 Dec;96(12):1375-1385. DOI:10.1007/s00109-018-1708-8 2018
Progranulin associates with hexosaminidase A and ameliorates GM2 ganglioside accumulation and lysosomal storage in Tay-Sachs disease [0.03%]
脯拉格林与己糖胺酶A结合并改善Tay-Sachs病的GM2神经节苷脂累积和溶酶体贮积现象
Yuehong Chen,Jinlong Jian,Aubryanna Hettinghouse et al.
Yuehong Chen et al.
Tay-Sachs disease (TSD) is a lethal lysosomal storage disease (LSD) caused by mutations in the HexA gene, which can lead to deficiency of β-hexosaminidase A (HexA) activity and consequent accumulation of its substrate, GM2 ganglioside. Rec...
AdipoRon, an adiponectin receptor agonist, attenuates cardiac remodeling induced by pressure overload [0.03%]
脂肪细胞增生素受体激动剂AdipoRon可抑制压力超负荷诱导的心脏重构
Ning Zhang,Wen-Ying Wei,Hai-Han Liao et al.
Ning Zhang et al.
AdipoRon, a small-molecule adiponectin receptor (AdipoR) agonist, has been reported to be implicated in cardiovascular diseases. However, its role in pressure-overload-induced cardiac remodeling is still elusive. To elucidate the role of Ad...
Plasminogen/thrombomodulin signaling enhances VEGF expression to promote cutaneous wound healing [0.03%]
纤溶酶原/血栓调节蛋白信号促进血管内皮生长因子表达以加速皮肤伤口愈合
Tsung-Lin Cheng,Po-Ku Chen,Wei-Kai Huang et al.
Tsung-Lin Cheng et al.
Plasminogen (Plg) and thrombomodulin (TM) are glycoproteins well known for fibrinolytic and anticoagulant functions, respectively. Both Plg and TM are essential for wound healing. However, their significance during the reparative process wa...
TRIB2 regulates the differentiation of MLL-TET1 transduced myeloid progenitor cells [0.03%]
TRIB2调控MLL-TET1转导的髓系祖细胞分化
Hyeng-Soo Kim,Seung Hwan Oh,Ju-Heon Kim et al.
Hyeng-Soo Kim et al.
The function and mechanism of action of MLL-TET1 (MT1) fusion protein in hematological cells are unclear and require further investigation. In the present study, we found that the MT1 fusion protein attenuated the expression of Cebpa, Csf1r...
Pentraxin 3 promotes long-term cerebral blood flow recovery, angiogenesis, and neuronal survival after stroke [0.03%]
pentraxin 3促进脑卒中后的长期脑血流恢复、血管生成和神经元存活
Ivana Rajkovic,Raymond Wong,Eloise Lemarchand et al.
Ivana Rajkovic et al.
Restoration of cerebral blood flow (CBF) and upregulation of angiogenesis are crucial for brain repair and functional recovery after cerebral ischaemia. Pentraxin 3 (PTX3) is a key regulator of angiogenesis and is emerging as a promising ta...
The combination of everolimus and terameprocol exerts synergistic antiproliferative effects in endometrial cancer: molecular role of insulin-like growth factor binding protein 2 [0.03%]
依维莫司联合特拉美普库尔在子宫内膜癌中表现出协同的抗增殖作用：胰岛素样生长因子结合蛋白2的分子作用机制
Angel Chao,Chiao-Yun Lin,Ren-Chin Wu et al.
Angel Chao et al.
Oncogenic PIK3CA mutations are common in endometrial cancers, and the PI3K/AKT/mTOR pathway is targetable by drugs. We sought to investigate whether the combination of an mTOR inhibitor, everolimus (RAD001), and an AKT inhibitor, terameproc...
Nuclear calcineurin is a sensor for detecting Ca2+ release from the nuclear envelope via IP3R [0.03%]
核定位的蛋白磷酸酶钙调素依赖核酸酶是IP3受体介导的内核膜钙释放感应器
Silvana Olivares-Florez,Martin Czolbe,Fabian Riediger et al.
Silvana Olivares-Florez et al.
In continuously beating cells like cardiac myocytes, there are rapid alterations of cytosolic Ca2+ levels. We therefore hypothesize that decoding Ca2+ signals for hypertrophic signaling requires intracellular Ca2+ microdomains that are part...
Trichostatin A, a histone deacetylase inhibitor, induces synergistic cytotoxicity with chemotherapy via suppression of Raf/MEK/ERK pathway in urothelial carcinoma [0.03%]
表皮生长因子受体酪氨酸激酶抑制剂通过抑制雷帕霉素的机械靶点信号通路增强沙利度胺对膀胱移行细胞癌的毒性作用
Wei-Chou Lin,Fu-Shun Hsu,Kuan-Lin Kuo et al.
Wei-Chou Lin et al.
In this study, we aimed to investigate the antitumor effects of trichostatin A (TSA), an antifungal antibiotic that inhibits histone deacetylase (HDAC) family of enzymes, alone or in combination with anyone of the three chemotherapeutic age...