Nicotinamide riboside alleviates sepsis-induced acute kidney injury by suppressing ferroptosis [0.03%]
烟酰胺核糖通过抑制铁死亡缓解脓毒症诱导的急性肾损伤
Shaohua Fan,Xiaohui Ma,Tiantian Ren et al.
Shaohua Fan et al.
Sepsis-induced acute kidney injury (SAKI) is the predominant type of acute kidney injury encountered in intensive care units. Nicotinamide riboside (NR) improves kidney function in acute and chronic kidney diseases; however, its role in SAK...
Nan Jiang,Wenjing Ma,Xiaodong Jin
Nan Jiang
Bladder cancer ranks among the most common malignancies of the urinary system. Despite continuous advances in treatment technologies, the risk of tumor progression and metastasis remains high due to its extreme heterogeneity, resulting in p...
Preclinical evaluation of [11C]CHDI-009R for quantification of mutant huntingtin aggregates [0.03%]
[11C]CHDI-009R 用于突变亨廷顿蛋白聚集体定量的临床前评估
Franziska Zajicek,Liesbeth Everix,Annemie Van Eetveldt et al.
Franziska Zajicek et al.
Huntington's disease (HD) is a neurodegenerative disorder caused by an expanded trinucleotide repeat in the huntingtin gene (HTT) that subsequently leads to aggregation of the mutant huntingtin (mHTT) protein. Thus, lowering mHTT is a key t...
Oxidative stress, mitochondrial dysfunction, and ferroptosis in the placenta of gestational diabetes mellitus [0.03%]
妊娠糖尿病胎盘的氧化应激、线粒体功能障碍和铁死亡
Xuan Zhou,Huiting Zhang,Lijie Wei et al.
Xuan Zhou et al.
Gestational diabetes mellitus (GDM) has become a significant concern in the domain of women's health. The pathophysiology of GDM is complicated and not entirely understood. As a functional interface of the maternal and fetal metabolisms, it...
Astragaloside IV inhibits the progression of hypertensive heart disease via the RXRA/PPARG/SIRT3 axis [0.03%]
Astragaloside IV通过RXRA/PPARG/SIRT3轴抑制高血压性心脏病的进展
Haoran Jing,Wenjie Cai,Xiaoxue Li et al.
Haoran Jing et al.
Astragaloside IV (AS-IV) is an active component of Astragalus membranaceus, which has a prominent role in cardiovascular diseases. AS-IV has been reported to alleviate vascular endothelial dysfunction and promote angiogenesis. However, its ...
Rongkun Zhu,Jizhou Pan,Yucong Min et al.
Rongkun Zhu et al.
Traumatic brain injury (TBI) is a leading cause of mortality and long-term disability worldwide, with secondary injuries amplifying neuronal damage through mechanisms such as ferroptosis-a regulated iron-dependent cell death driven by lipid...
Dapagliflozin inhibits TGF-β-induced transdifferentiation of valvular interstitial cells and mitral valvular degeneration [0.03%]
达格列净通过抑制转化生长因子诱导的瓣膜间质细胞转分化及二尖瓣退行性变发挥作用
Remi Sato,Kosei Sakai,Satoshi Kameshima
Remi Sato
Myxomatous mitral valve (MV) disease (MMVD) is a common cardiac condition in humans and dogs. Currently, no therapeutic agent is available for MMVD that can prevent MV degeneration. Transforming growth factor (TGF)-β-induced transdifferent...
ApoA5-CIDEC axis regulates hepatic lipid metabolism, inflammation, and fibrosis in MASLD [0.03%]
ApoA5-CIDEC轴调节MASLD肝脂代谢、炎症和纤维化
Chenjie Li,Dongjie Yang,Xiaowen Wang et al.
Chenjie Li et al.
Apolipoprotein A5 (ApoA5) and Cell Death-Inducing DNA Fragmentation Factor-like Effector C (CIDEC) are involved in hepatic lipid metabolism and implicated in metabolic dysfunction-associated steatotic liver disease (MASLD). This study explo...
Stem cells strike back: advancements in Alzheimer's and Parkinson's disease treatment and modeling efforts from 2019 to 2024 [0.03%]
干细胞反击：2019至2024年阿尔茨海默病和帕金森病治疗及建模研究进展
Jasmina Isaković,Anna Athanassiadis,Marian Khubeis
Jasmina Isaković
This review critically evaluates the current state of stem cell therapy (SCT) for treating and modeling of Alzheimer's (AD) and Parkinson's disease (PD). It includes an in-depth analysis of both preclinical and clinical studies, with a part...
The multifaceted roles of MCAM in development, homeostasis, pathological conditions, and cancer [0.03%]
MCAM在发育、稳态、病理条件和癌症中的多种作用
Bartosz Mierzejewski,Dominika Kulma,Edyta Brzoska
Bartosz Mierzejewski
MCAM (melanoma cell adhesion molecule), identified in human melanoma in 1987, has garnered attention due to its diverse roles in development, homeostasis, and various diseases, including cancer. Initially recognized for its differential exp...