Raymond Sammut,Gavin Huttley
Raymond Sammut
Sequence divergence derives from either point substitution or indel (insertion or deletion) processes. We investigated the rates of these two processes both in protein and non-protein coding DNA. We aligned sequence pairs using two pair-hid...
Large tandem, higher order repeats and regularly dispersed repeat units contribute substantially to divergence between human and chimpanzee Y chromosomes [0.03%]
大规模串联、高阶重复序列及规律分布的重复单元对人类和黑猩猩Y染色体分化有重要贡献
Vladimir Paar,Matko Glunčić,Ivan Basar et al.
Vladimir Paar et al.
Comparison of human and chimpanzee genomes has received much attention, because of paramount role for understanding evolutionary step distinguishing us from our closest living relative. In order to contribute to insight into Y chromosome ev...
Comparative Study
Journal of molecular evolution. 2011 Jan;72(1):34-55. DOI:10.1007/s00239-010-9401-8 2011
Selective pressure to increase charge in immunodominant epitopes of the H3 hemagglutinin influenza protein [0.03%]
选择性压力促使H3血凝素流感蛋白免疫优势表位带电残基增加
Keyao Pan,Jinxue Long,Haoxin Sun et al.
Keyao Pan et al.
The evolutionary speed and the consequent immune escape of H3N2 influenza A virus make it an interesting evolutionary system. Charged amino acid residues are often significant contributors to the free energy of binding for protein-protein i...
Proteome evolution and the metabolic origins of translation and cellular life [0.03%]
蛋白质组进化及代谢在翻译和细胞生命起源中的作用
Derek Caetano-Anollés,Kyung Mo Kim,Jay E Mittenthal et al.
Derek Caetano-Anollés et al.
The origin of life has puzzled molecular scientists for over half a century. Yet fundamental questions remain unanswered, including which came first, the metabolic machinery or the encoding nucleic acids. In this study we take a protein-cen...
Evolution of the relaxin/insulin-like gene family in placental mammals: implications for its early evolution [0.03%]
哺乳动物中relaxin/胰岛素样基因家族的进化及其早期进化意义
Federico G Hoffmann,Juan C Opazo
Federico G Hoffmann
The relaxin (RLN) and insulin-like (INSL) gene family is a group of genes involved in a variety of physiological roles that includes bone formation, testicular descent, trophoblast development, and cell differentiation. This family appears ...
Marek Gabriško,Stefan Janeček
Marek Gabriško
To reveal evolutionary history of maltase gene family in the genus Drosophila, we undertook a bioinformatics study of maltase genes from available genomes of 12 Drosophila species. Molecular evolution of a closely related glycoside hydrolas...
Anna A Vakhrusheva,Marat D Kazanov,Andrey A Mironov et al.
Anna A Vakhrusheva et al.
De novo origin of coding sequence remains an obscure issue in molecular evolution. One of the possible paths for addition (subtraction) of DNA segments to (from) a gene is stop codon shift. Single nucleotide substitutions can destroy the ex...
Male sex interspecies divergence and down regulation of expression of spermatogenesis genes in Drosophila sterile hybrids [0.03%]
雄性生殖隔离及果蝇不育杂交种中精子发生基因表达下调
Vignesh Sundararajan,Alberto Civetta
Vignesh Sundararajan
Male sex genes have shown a pattern of rapid interspecies divergence at both the coding and gene expression level. A common outcome from crosses between closely-related species is hybrid male sterility. Phenotypic and genetic studies in Dro...
The last universal common ancestor (LUCA) and the ancestors of archaea and bacteria were progenotes [0.03%]
最后的普遍共同祖先(LUCA)以及考古菌和细菌的祖先都是原基因体生物
Massimo Di Giulio
Massimo Di Giulio
The tRNA split genes of Nanoarchaeum equitans and the Met-tRNA(fMet) → fMet-tRNA(fMet) pathway, identifiable as ancestral traits, and the late appearance of DNA are used to understand the evolutionary stage at which the progenote → genote...
Selection and the cell cycle: positive Darwinian selection in a well-known DNA damage response pathway [0.03%]
选择与细胞周期：著名DNA损伤反应通路中的正达尔文选择
Mary J O&#x;Connell
Mary J O&#x;Connell
Cancer is a common occurrence in multi-cellular organisms and is not strictly limited to the elderly in a population. It is therefore possible that individuals with genotypes that protect against early onset cancers have a selective advanta...