Functional Equivalence and Conserved Sexual Dimorphism in the Gut Microbiome: A Cross-Species Meta-analysis [0.03%]
功能等价性与保守的性别二态性在肠道微生物组中的存在——跨物种元分析研究
Jorge Luis Gutiérrez-Ávila,Gabriel Alfonso Gutiérrez-Rebolledo,Rodolfo Gamaliel Avila-Bonilla et al.
Jorge Luis Gutiérrez-Ávila et al.
The murine model is a standard system in translational microbiome research, yet its functional equivalence to the human microbiome remains debated. To evaluate its translational validity, we conducted a comparative whole-genome shotgun (WGS...
CGGBP1-Regulated Heterogeneous C-T Transition Rates Correlate with G-quadruplex Potential of Terrestrial Vertebrate Genomes [0.03%]
陆生脊椎动物基因组中受CGGBP1调控的不均一C到T转换率与G-四链体位点分布相关性研究
Praveen Kumar,Umashankar Singh
Praveen Kumar
The formation of G-quadruplexes (G4) is fundamentally linked to DNA GC content. With no reports of evolutionary selection of G4 stabilizing genes, it is arguable that G4 formation depends primarily on inherent sequence properties. Vertebrat...
Evaluation of Molecular Phylogenetic Trees by an Information-Theoretic Metric [0.03%]
利用信息论度量评价分子系统发育树
Takuma Nishimaki,Keiko Sato
Takuma Nishimaki
Understanding phylogenetic relationships among species is fundamental to many biological studies. Constructing phylogenetic trees based on molecular data is important not only for considering the evolution and classification of organisms, b...
Highly Conserved Core Residues Define Old-World Alphaviruses and Trace Early Evolutionary Divergence [0.03%]
高度保守的核心残基界定旧大陆alphavirus并追溯早期进化分歧
Wendy Carolina Piña-Ruiz,Luis Rubén Jaime-Rocha,Andrea Castorena-Robles et al.
Wendy Carolina Piña-Ruiz et al.
Alphaviruses are positive-sense, single-stranded RNA viruses that assemble into striking double-icosahedral particles. During budding, the nucleocapsid core forms in the cytoplasm and adopts a T = 4 icosahedral symmetry, a hallmark characte...
Evolutionary Signatures of Thermotolerance Shaped by Adaptive Admixtures in the Ghurrah Pig of India [0.03%]
印度Ghurrah猪适应性杂交形成的耐热性的进化特征
Rangasai Chandra Goli,Kiyevi G Chishi,Oguru Sai Sruthi et al.
Rangasai Chandra Goli et al.
India's indigenous pig genetic resources are central to sustainable meat production and rural livelihoods, yet their genomic potential remains underexplored. The Ghurrah pig, a native breed from northern India, is among the most genetically...
Transcription Factor Evolution Associated with Social Transitions in Blattodea [0.03%]
蜚蠊目动物的社会过渡与转录因子进化之间的关系
Alun R C Jones,Elias Dohmen,Juliette Berger et al.
Alun R C Jones et al.
The phenotypic diversity between castes in social species has been associated with increased regulation of gene expression. while the regulatory role of transcription factors (TFs) in the social transitions of Hymenoptera (bees, ants and wa...
Sequence Conservation and Functional Significance of Charged Clusters in Mitochondria-Located Proteins of Green Plants [0.03%]
高等植物线粒体定位蛋白上带电残基簇的保守性及生物学功能意义
Syrine Nebli,Ahmed Rebai,Imen Ayadi
Syrine Nebli
Charged Clusters (CC), subclasses of Intrinsically Disordered Protein Regions (IDPR), are vital for protein function by mediating electrostatic interactions, metal binding, and serving as hotspots for post-translational modifications. The e...
Classification of SARS-CoV-2 Variants Through the Epistatic Circos Plots with Convolutional Neural Networks [0.03%]
基于遗传相互作用的 Circos 图通过卷积神经网络分类 SARS-CoV-2 变异毒株
Bo Jing,Kai-Rui Zhang,Hong-Li Zeng et al.
Bo Jing et al.
The COVID-19 pandemic has profoundly affected global health, driven by the remarkable transmissibility and mutational adaptability of the SARS-CoV-2 virus. Although five variants of concern, Alpha, Beta, Gamma, Delta, and Omicron, have been...
Evolutionary Transitions Drive Molecular Adaptation in Sculpin Rhodopsin [0.03%]
进化转变驱动四棱鱼视紫红质分子适应性演化
Esmé S B Macpherson,Belinda S W Chang,Nathan R Lovejoy
Esmé S B Macpherson
Evolutionary habitat transitions are known to drive rapid evolution. In fishes, switches between marine and freshwater can promote adaptation in sensory systems; in particular, the disparate visual environments in these aquatic habitats can...
Resurrecting tRNAs of the Last Universal Common Ancestor (Commonote) Toward Rebuilding the Ancient Translation System [0.03%]
复活最后一个普遍共同祖先(tRNA)重建古翻译系统
Kei Yamanouchi,Hinata Moriya,Shin-Ichi Yokobori
Kei Yamanouchi
Ancestral sequence reconstruction (ASR) was used to study the evolution of the translational system by inferring tRNA sequences of the Last Archaeal Common Ancestor (LACA), the Last Bacterial Common Ancestor (LBCA), and the Last Universal C...