Conditions Enabling the Persistence of Cooperating Synthetase, Ligase, and Mutation-Inhibitor Catalytic Polymers [0.03%]
使合作合成酶、连接酶和变异性抑制剂催化的催化聚合物得以共存的条件
Zhen Peng,Alex M Plum,Rahul Kartha et al.
Zhen Peng et al.
In origins-of-life research, a key challenge is to explain the emergence of polymers of sufficient length to confer the complex functions needed for genetic inheritance. Previous studies have demonstrated that prebiotic environments enablin...
Lineage-Specific Diversification of Nucleoporin Nup98 Genes in Ciliates and Its Evolutionary Implications for the Nuclear Dualism [0.03%]
纤毛虫Nup98 核孔蛋白基因的谱系特异性分化及其对细胞核二象性进化意义的研究
Masaaki Iwamoto
Masaaki Iwamoto
Nup98 is a key component of the nuclear pore complex that plays essential roles in nucleocytoplasmic transport and gene regulation. To investigate the evolutionary diversification of Nup98 in ciliates, homologous sequences were collected fr...
Mitochondrial Genome Evolution: The Influence of Partitioning, Calibration, and Gene Heterogeneity on Pleurodontan Substitution Rates [0.03%]
线粒体基因组进化：分异化、校准和基因异质性对pleurodontan置换率的影响
Matheus M A Salles,Fabricius M C B Domingos
Matheus M A Salles
Substitution rate estimates are central to evolutionary biology, underpinning divergence-time inference and a wide range of macroevolutionary analyses. Mitochondrial DNA (mtDNA) rates are widely used for this purpose, yet they are often der...
Advances in Contact Tracing: A Bayesian Framework to Improve Network and Transmission Models [0.03%]
基于贝叶斯框架改善网络和传播接触者追踪的进展
Jessica L Hite
Jessica L Hite
Non‑pharmaceutical interventions such as contact tracing, quarantine, and targeted restrictions remain central to outbreak control. Yet, their success depends on understanding how pathogens spread through heterogeneous populations. Here, I...
User Guided Selection and Alignment of Sequence Data by GeneMatrix [0.03%]
GeneMatrix：用户自主导向的序列数据分析及排序
Simon J Goodman,Ian M Carr
Simon J Goodman
The alignment of multiple protein or DNA sequences is a common task in many biological fields. These alignments may then be used to identify conserved regions or positions, which could in turn be used to score the likely pathogenicity of a ...
When Complex Models Fit the Wrong Mechanistic Complexity in Phylogenomic Analysis [0.03%]
复杂模型在系统基因组分析中拟合错误的机制复杂性时的情形
Liang Liu,David A Liberles
Liang Liu
Substitution model selection is central to phylogenetic inference and is commonly treated as a problem of identifying the substitutional complexity required to describe sequence evolution along a single tree. This framework implicitly assum...
Evolutionary Study of Transposable Elements: Structural Characterization and Phylogenomic Profiling in Plant Genomes [0.03%]
植物基因组中转座元件的进化研究：结构特征和系统基因组分析
Pawan Kumar Jayaswal,Nagendra Kumar Singh
Pawan Kumar Jayaswal
Transposable elements (TEs) are dynamic DNA sequences that play a significant role in shaping genome structure and function in eukaryotic species. Advances in next-generation sequencing technologies have enhanced our understanding of the ab...
Qi Cao,Yuange Duan
Qi Cao
Transcriptional adaptation (TA) works through a mechanism in which ILF3 binds degradation fragments of aberrant mRNAs and upregulates a sequence-related "adapting gene" for expressional compensation. It is worth thinking whether the entire ...
Concatenation, Conflict, and Complexity: Genealogical Heterogeneity Mimics Substitutional Heterogeneity for Nucleotide Model Selection [0.03%]
串联、冲突与复杂性：谱系异质性模拟核苷酸模型选择中的替换异质性
Jenniffer Roa Lozano,Mahamad Sayab Miya,Emma Turner et al.
Jenniffer Roa Lozano et al.
Phylogenetic conflict-particularly hidden gene-tree discordance generated by incomplete lineage sorting (ILS)-is pervasive in multilocus and phylogenomic datasets, yet its consequences for nucleotide substitution model selection remain poor...
Integrative Structural Bioinformatics and Molecular Dynamics Analyses of Synaptic Vesicle Proteins and Their Water-Soluble QTY-Variants Reveal Membrane Constraints and Evolutionary Coupling of T ⇔ V [0.03%]
整合结构生物信息学和分子动力学分析：膜蛋白突触囊泡及其水溶性QTY变异体的结构约束及T⇔V间的协同进化分析
Taner Karagöl,Alper Karagöl,Shuguang Zhang
Taner Karagöl
Synaptic vesicle proteins, including the synaptophysin, synaptogyrins, and synaptic vesicle glycoprotein 2 family are fundamental for neurotransmitter release and synaptic function, influencing numerous physiological processes. Although the...