Molecular evolution and characterization of fungal indoleamine 2,3-dioxygenases [0.03%]
真菌脱氢异雄酮-2,3-二氧酶的分子进化和性质研究
Hajime J Yuasa,Helen J Ball
Hajime J Yuasa
Indoleamine 2,3-dioxygenase (IDO) and tryptophan 2,3-dioxygenase (TDO) are tryptophan-degrading enzymes. Mammalian IDO expression is induced by cytokines and has antimicrobial and immunomodulatory effects. A major role of mammalian TDO is t...
Gene duplication and divergence of long wavelength-sensitive opsin genes in the guppy, Poecilia reticulata [0.03%]
孔雀鱼(Poecilia reticulata)长波敏感型视蛋白基因的复制与分化
Corey T Watson,Suzanne M Gray,Margarete Hoffmann et al.
Corey T Watson et al.
Female preference for male orange coloration in the genus Poecilia suggests a role for duplicated long wavelength-sensitive (LWS) opsin genes in facilitating behaviors related to mate choice in these species. Previous work has shown that LW...
Poly(T) variation in heteroderid nematode mitochondrial genomes is predominantly an artefact of amplification [0.03%]
异皮目线虫线粒体基因组中 Poly(T) 多态性主要来源于扩增过程中的扩增子伪基因效应
Angelique H Riepsamen,Tracey Gibson,Janet Rowe et al.
Angelique H Riepsamen et al.
We assessed the rate of in vitro polymerase errors at polythymidine [poly(T)] tracts in the mitochondrial DNA (mtDNA) of a heteroderid nematode (Heterodera cajani). The mtDNA of these nematodes contain unusually high numbers of poly(T) trac...
Population-specific links between heterozygosity and the rate human microsatellite evolution [0.03%]
等位基因杂合度与人群特异性微卫星进化速率之间的联系
William Amos
William Amos
Microsatellites form an abundant class of DNA sequences used widely as genetic markers. Surprisingly, the length of human microsatellites varies highly predictably with distance from Africa, apparently following the linear decline in variab...
Zohar Koren,Edward N Trifonov
Zohar Koren
Analysis of occurrence of simple amino acid repeats in large ensemble of prokaryotic and eukaryotic sequences reveals that nearly all amino acids found in the repeats belong to those which have in their codon repertoires aggressively expand...
Amino acid compositional shifts during streptophyte transitions to terrestrial habitats [0.03%]
拟南芥适应陆生环境过程中氨基酸组成的转变
Richard W Jobson,Yin-Long Qiu
Richard W Jobson
Across the streptophyte lineage, which includes charophycean algae and embryophytic plants, there have been at least four independent transitions to the terrestrial habitat. One of these involved the evolution of embryophytes (bryophytes an...
Molecular variability and evolution of the pectate lyase (pel-2) parasitism gene in cyst nematodes parasitizing different solanaceous plants [0.03%]
寄生不同茄科植物的囊属线虫pectate lyase(pel-2)致病基因的分子变异和进化研究
Barbara Geric Stare,Didier Fouville,Saša Širca et al.
Barbara Geric Stare et al.
While pectate lyases are major parasitism factors in plant-parasitic nematodes, there is little information on the variability of these genes within species and their utility as pathotype or host range molecular markers. We have analysed po...
Introns form compositional clusters in parallel with the compositional clusters of the coding sequences to which they pertain [0.03%]
内含子与其相应的编码序列组成簇平行地形成组成簇
Miguel A Fuertes,José M Pérez,Emile Zuckerkandl et al.
Miguel A Fuertes et al.
This report deals with the study of compositional properties of human gene sequences evaluating similarities and differences among functionally distinct sectors of the gene independently of the reading frame. To retrieve the compositional i...
Exploiting models of molecular evolution to efficiently direct protein engineering [0.03%]
利用分子进化模型有效指导蛋白质工程
Megan F Cole,Eric A Gaucher
Megan F Cole
Directed evolution and protein engineering approaches used to generate novel or enhanced biomolecular function often use the evolutionary sequence diversity of protein homologs to rationally guide library design. To fully capture this seque...
Phylogenetic and functional analysis of the vertebrate cytochrome p450 2 family [0.03%]
脊椎动物细胞色素P450 2族的谱系和功能分析
Nina Kirischian,Andrew G McArthur,Caroline Jesuthasan et al.
Nina Kirischian et al.
Cytochrome P450 (CYP) proteins compose a highly diverse superfamily found in all domains of life. These proteins are enzymes involved in metabolism of endogenous and exogenous compounds. In vertebrates, the CYP2 family is one of the largest...